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Afr1p has a role in regulating the localization of Mpk1p at the shmoo tip in Saccharomyces cerevisiae.

Changwei Z., Mingyong X., Ranran W.

FEBS Lett. 581:2670-2674(2007) GeneRIF 851658 SGD S000002492 · Mapped (3)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000002492 Results indicate that deletion of AFR1 results in mislocalization of Mpk1p. GeneRIF 851658

Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating.

Bharucha J.P., Larson J.R., Konopka J.B., Tatchell K.

Eukaryotic Cell 7:1246-1255(2008) GeneRIF 851658 SGD S000002492 · Mapped (5)
Cellular Location|Function/Process|Mutants/Phenotypes|Protein-protein Interactions|Strains/Constructs|Techniques and Reagents SGD S000002492 These results demonstrate a previously unknown role for Afr1 in targeting Glc7 to mating projections and in regulating the septin architecture during mating. GeneRIF 851658

The yeast pheromone-responsive G alpha protein stimulates recovery from chronic pheromone treatment by two mechanisms that are activated at distinct levels of stimulus.

Zhou J., Arora M., Stone D.E.

Cell Biochem. Biophys. 30:193-212(1999) SGD S000002492 · UniProtKB (1) · Mapped (8)
Other Features SGD S000002492

Combining mutations in the incoming and outgoing pheromone signal pathways causes a synergistic mating defect in Saccharomyces cerevisiae.

Giot L., DeMattei C., Konopka J.B.

Yeast 15:765-780(1999) SGD S000002492 · Mapped (9)
Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000002492

Point mutations identify a conserved region of the saccharomyces cerevisiae AFR1 gene that is essential for both the pheromone signaling and morphogenesis functions.

DeMattei C.R., Davis C.P., Konopka J.B.

Genetics 155:43-55(2000) SGD S000002492 · Mapped (3)
Function/Process|Fungal Related Genes/Proteins|Mutants/Phenotypes|Non-Fungal Related Genes/Proteins|Protein-protein Interactions|Regulation of|Regulatory Role|Strains/Constructs SGD S000002492

Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins.

Harris K., Lamson R.E., Nelson B., Hughes T.R., Marton M.J., Roberts C.J., Boone C., Pryciak P.M.

Curr. Biol. 11:1815-1824(2001) SGD S000002492 · Mapped (46)
RNA Levels and Processing|Regulation of SGD S000002492

Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling.

Zeitlinger J., Simon I., Harbison C.T., Hannett N.M., Volkert T.L., Fink G.R., Young R.A.

Cell 113:395-404(2003) SGD S000002492 · UniProtKB (4) · Mapped (61)
Regulation of SGD S000002492

The budding index of Saccharomyces cerevisiae deletion strains identifies genes important for cell cycle progression.

Zettel M.F., Garza L.R., Cass A.M., Myhre R.A., Haizlip L.A., Osadebe S.N., Sudimack D.W., Pathak R., Stone T.L., Polymenis M.

FEMS Microbiol. Lett. 223:253-258(2003) SGD S000002492 · UniProtKB (5) · Mapped (72)
Cell Cycle Phase Involved|Mutants/Phenotypes SGD S000002492

Characterization of the transcriptional response to cell wall stress in Saccharomyces cerevisiae.

Boorsma A., de Nobel H., ter Riet B., Bargmann B., Brul S., Hellingwerf K.J., Klis F.M.

Yeast 21:413-427(2004) SGD S000002492 · UniProtKB (9) · Mapped (51)
Regulation of SGD S000002492

Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media.

Lai L.C., Kosorukoff A.L., Burke P.V., Kwast K.E.

Mol. Cell. Biol. 25:4075-4091(2005) SGD S000002492 · Mapped (379)
RNA Levels and Processing|Regulation of SGD S000002492

Adaptation of Saccharomyces cerevisiae to high hydrostatic pressure causing growth inhibition.

Iwahashi H., Odani M., Ishidou E., Kitagawa E.

FEBS Lett. 579:2847-2852(2005) SGD S000002492 · Mapped (26)
RNA Levels and Processing SGD S000002492

The thioredoxin system protects ribosomes against stress-induced aggregation.

Rand J.D., Grant C.M.

Mol. Biol. Cell 17:387-401(2006) SGD S000002492 · UniProtKB (2) · Mapped (194)
Mutants/Phenotypes SGD S000002492

Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae.

Chou S., Lane S., Liu H.

Mol. Cell. Biol. 26:4794-4805(2006) SGD S000002492 · Mapped (45)
DNA/RNA Sequence Features|Regulation of SGD S000002492

Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation.

Kramer R.W., Slagowski N.L., Eze N.A., Giddings K.S., Morrison M.F., Siggers K.A., Starnbach M.N., Lesser C.F.

PLoS Pathog. 3:179-190(2007) SGD S000002492 · UniProtKB (1) · Mapped (63)
S000002492 SGD S000002492

Identifying gene regulatory modules of heat shock response in yeast.

Wu W.S., Li W.H.

BMC Genomics 9:439-439(2008) SGD S000002492 · Mapped (202)
Regulation of SGD S000002492

Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast.

de Godoy L.M., Olsen J.V., Cox J., Nielsen M.L., Hubner N.C., Frohlich F., Walther T.C., Mann M.

Nature 455:1251-1254(2008) SGD S000002492 · Mapped (44)
Protein Physical Properties SGD S000002492

A predictive model of the oxygen and heme regulatory network in yeast.

Kundaje A., Xin X., Lan C., Lianoglou S., Zhou M., Zhang L., Leslie C.

PLoS Comput. Biol. 4:e1000224-e1000224(2008) SGD S000002492 · Mapped (77)
S000002492 SGD S000002492

Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor.

Rancati G., Pavelka N., Fleharty B., Noll A., Trimble R., Walton K., Perera A., Staehling-Hampton K., Seidel C.W., Li R.

Cell 135:879-893(2008) SGD S000002492 · Mapped (16)
RNA Levels and Processing|Transcription SGD S000002492

The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acids.

Mira N.P., Lourenco A.B., Fernandes A.R., Becker J.D., Sa-Correia I.

FEMS Yeast Res. 9:202-216(2009) SGD S000002492 · Mapped (38)
RNA Levels and Processing SGD S000002492

The high osmotic response and cell wall integrity pathways cooperate to regulate transcriptional responses to zymolyase-induced cell wall stress in Saccharomyces cerevisiae.

Garcia R., Rodriguez-Pena J.M., Bermejo C., Nombela C., Arroyo J.

J. Biol. Chem. 284:10901-10911(2009) SGD S000002492 · Mapped (92)
RNA Levels and Processing|Regulation of SGD S000002492

Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks.

Huang S.S., Fraenkel E.

Sci Signal 2:ra40-ra40(2009) SGD S000002492 · Mapped (21)
S000002492 SGD S000002492

Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae.

Rintala E., Toivari M., Pitkanen J.P., Wiebe M.G., Ruohonen L., Penttila M.

BMC Genomics 10:461-461(2009) SGD S000002492 · Mapped (246)
Regulation of|Transcription SGD S000002492

Analysis of a 32.8 kb segment of yeast chromosome IV reveals 21 open reading frames, including TPS2, PPH3, RAD55, SED1, PDC2, AFR1, SSS1, SLU7 and a tRNA for arginine.

Coster F., Jonniaux J.-L., Goffeau A.

Yeast 11:673-679(1995) SGD S000002492 · UniProtKB (5) · Mapped (8)
DNA/RNA Sequence Features SGD S000002492

Transcriptional interference caused by GCN4 overexpression reveals multiple interactions mediating transcriptional activation.

Tavernarakis N., Thireos G.

Mol. Gen. Genet. 247:571-578(1995) SGD S000002492 · Mapped (4)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Regulatory Role SGD S000002492

AFR1 promotes polarized apical morphogenesis in Saccharomyces cerevisiae.

Konopka J.B., DeMattei C., Davis C.

Mol. Cell. Biol. 15:723-730(1995) SGD S000002492 · Mapped (5)
Cellular Location|Function/Process|Genetic Interactions|Mutants/Phenotypes|Protein-protein Interactions|Regulation of|Regulatory Role|Strains/Constructs|Techniques and Reagents SGD S000002492

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