Shin B.K., Wang H., Yim A.M., Le Naour F., Brichory F., Jang J.H., Zhao R., Puravs E., Tra J., Michael C.W. et al.

J. Biol. Chem. 278:7607-7616(2003) GeneRIF 923 · Mapped (12)
Comprehensive profiling of the cell surface proteome provides an effective approach for the identification of commonly occurring proteins as well as proteins with restricted expression patterns in this compartment. GeneRIF 923

Gimferrer I., Ibanez A., Farnos M., Sarrias M.R., Fenutria R., Rosello S., Zimmermann P., David G., Vives J., Serra-Pages C. et al.

J. Immunol. 175:1406-1414(2005) GeneRIF 923 MINT MINT-1351620 MINT MINT-1351620 MINT MINT-1351620 MINT MINT-1351620 MINT MINT-1351620 MINT MINT-1351620 · Mapped (26)
CD6 associates with the scaffolding PDZ-containing protein syntenin-1 during maturation of the immunological synapse GeneRIF 923 MINT-62372. CD6 (uniprotkb:P30203) physically interacts (MI:0915) with Sdcbp (uniprotkb:O08992) by two hybrid pooling approach (MI:0398). From mint MINT MINT-1351620 MINT-62373. CD6 (uniprotkb:P30203) physically interacts (MI:0915) with Sdcbp (uniprotkb:O08992) by two hybrid array (MI:0397). From mint MINT MINT-1351620 MINT-62374. Sdcbp (uniprotkb:O08992) physically interacts (MI:0915) with CD6 (uniprotkb:P30203) by pull down (MI:0096). From mint MINT MINT-1351620 MINT-62375. CD6 (uniprotkb:P30203) physically interacts (MI:0915) with Sdcbp (uniprotkb:O08992) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-1351620 MINT-62376. CD6 (uniprotkb:P30203) physically interacts (MI:0915) with SDCBP (uniprotkb:O00560) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-1351620 MINT-62377. SDCBP (uniprotkb:O00560) and CD6 (uniprotkb:P30203) colocalize (MI:0403) by colocalization by immunostaining (MI:0022). From mint MINT MINT-1351620

Kato Y., Tanaka Y., Hayashi M., Okawa K., Minato N.

J. Immunol. 177:877-884(2006) GeneRIF 923 · Mapped (17)
Engagement of CD6 with CD166 on tumor cells plays an important role in gammadelta T cell activation by tumor cells sensitized with nonpeptide antigens endogenously or exogenously. GeneRIF 923

Ibanez A., Sarrias M.R., Farnos M., Gimferrer I., Serra-Pages C., Vives J., Lozano F.

J. Immunol. 177:1152-1159(2006) GeneRIF 923 · Mapped (17)
the CD6-ALCAM interaction results in activation of the three MAP kinase cascades likely influencing the dynamic balance that determines whether resting or activated lymphocytes survive or undergo apoptosis. GeneRIF 923

Hassan N.J., Simmonds S.J., Clarkson N.G., Hanrahan S., Puklavec M.J., Bomb M., Barclay A.N., Brown M.H.

Mol. Cell. Biol. 26:6727-6738(2006) GeneRIF 923 · Mapped (18)
The costimulatory effect of CD6 is mediated through phosphorylation-dependent binding of a specific tyrosine residue 662Y in its cytoplasmic region to the adaptor SLP-76. GeneRIF 923

Sarrias M.R., Farnos M., Mota R., Sanchez-Barbero F., Ibanez A., Gimferrer I., Vera J., Fenutria R., Casals C., Yelamos J. et al.

Proc. Natl. Acad. Sci. U.S.A. 104:11724-11729(2007) GeneRIF 923 · Mapped (12)
Unprecedented bacterial binding properties of recombinant soluble CD6 support its therapeutic potential for the intervention of septic shock syndrome or other inflammatory diseases of infectious origin. GeneRIF 923

Alonso R., Huerta V., de Leon J., Piedra P., Puchades Y., Guirola O., Chinea G., Montero E.

Hybridoma (Larchmt) 27:291-301(2008) GeneRIF 923 · Mapped (12)
A chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. GeneRIF 923

International MS Genetics Consortium
De Jager P.L., Jia X., Wang J., de Bakker P.I., Ottoboni L., Aggarwal N.T., Piccio L., Raychaudhuri S., Tran D., Aubin C. et al.

Nat. Genet. 41:776-782(2009) GeneRIF 923 GAD 597180 · Mapped (1,336)
Associated with IMMUNE: multiple sclerosis; GAD 597180 Replication in an independent set of 2 215 subjects with multiple sclerosis (MS) and 2 116 control subjects validates new MS susceptibility loci at TNFRSF1A IRF8 and CD6; TNFRSF1A harbors two independent susceptibility alleles; Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) GeneRIF 923

Johnson B.A., Wang J., Taylor E.M., Caillier S.J., Herbert J., Khan O.A., Cross A.H., De Jager P.L., Gourraud P.A., Cree B.C. et al.

Genes Immun. 11:343-350(2010) GeneRIF 923 · Mapped (347)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 923

De Jager P.L., Chibnik L.B., Cui J., Reischl J., Lehr S., Simon K.C., Aubin C., Bauer D., Heubach J.F., Sandbrink R. et al.

Lancet Neurol 8:1111-1119(2009) GeneRIF 923 · Mapped (1,365)
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) GeneRIF 923

Davila S., Froeling F.E., Tan A., Bonnard C., Boland G.J., Snippe H., Hibberd M.L., Seielstad M.

Genes Immun. 11:232-238(2010) GeneRIF 923 · Mapped (4,170)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 923

Swaminathan B., Matesanz F., Cavanillas M.L., Alloza I., Otaegui D., Olascoaga J., Cenit M.C., de las Heras V., Barcina M.G., Arroyo R. et al.

J. Neuroimmunol. 223:100-103(2010) GeneRIF 923 · Mapped (18)
Observational study of gene-disease association. (HuGE Navigator); Study reinforces a role for CD6 and TNFRSF1A as risk loci for multiple sclerosis extending to populations of southern European ancestry. GeneRIF 923

Nair P., Melarkode R., Rajkumar D., Montero E.

Clin. Exp. Immunol. 162:116-130(2010) GeneRIF 923 · Mapped (17)
Data show that CD6-ALCAM interaction in vitro induced a synergistic co-stimulation of normal peripheral blood mononuclear cells. GeneRIF 923

Alonso R., Buors C., Le Dantec C., Hillion S., Pers J.O., Saraux A., Montero E., Marianowski R., Loisel S., Devauchelle V. et al.

J. Autoimmun. 35:336-341(2010) GeneRIF 923 · Mapped (12)
CD6+ B cells are diminished in Sjogren's syndrome GeneRIF 923

Braun M., Muller B., ter Meer D., Raffegerst S., Simm B., Wilde S., Spranger S., Ellwart J., Mosetter B., Umansky L. et al.

J Innate Immun 3:420-434(2011) GeneRIF 923 · Mapped (12)
CD6 expression on peripheral NK cells marks a novel CD56(dim) subpopulation associated with distinct patterns of cytokine and chemokine secretion. GeneRIF 923

International Multiple Sclerosis Genetics Consortium

PLoS ONE 6:e18813-e18813(2011) GeneRIF 923 · Mapped (18)
association of single nucleotide polymorphisms to multiple sclerosis GeneRIF 923

Kofler D.M., Severson C.A., Mousissian N., De Jager P.L., Hafler D.A.

J. Immunol. 187:3286-3291(2011) GeneRIF 923 · Mapped (12)
These findings indicate that the multiple sclerosis risk allele in the CD6 locus is associated with altered proliferation of CD4(+) T cells GeneRIF 923

Oliveira M.I., Goncalves C.M., Pinto M., Fabre S., Santos A.M., Lee S.F., Castro M.A., Nunes R.J., Barbosa R.R., Parnes J.R. et al.

Eur. J. Immunol. 42:195-205(2012) GeneRIF 923 · Mapped (16)
Cd6 is a signaling attenuator whose expression alone i.e. in the absence of ligand engagement is sufficient to restrain signaling in T cells. GeneRIF 923

Krintel S.B., Essioux L., Wool A., Johansen J.S., Schreiber E., Zekharya T., Akiva P., Ostergaard M., Hetland M.L.

PLoS ONE 7:e38539-e38539(2012) GeneRIF 923 · Mapped (12)
Data suggest that genetic variations within CD6 and syntaxin binding protein 6 (STXBP6) may influence response to TNFalpha inhibitors in patients with rheumatoid arthritis (RA). GeneRIF 923