Harris S.E., Fox H., Wright A.F., Hayward C., Starr J.M., Whalley L.J., Deary I.J.

BMC Genet. 8:43-43(2007) GAD 595493 GeneRIF 10935 · Mapped (578)
Not Associated with NEUROLOGICAL: cognitive trait; GAD 595493 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10935

Starr J.M., Shiels P.G., Harris S.E., Pattie A., Pearce M.S., Relton C.L., Deary I.J.

Mech. Ageing Dev. 129:745-751(2008) GAD 595492 GeneRIF 10935 · Mapped (584)
Not Associated with AGING: Aging/ Telomere Length; GAD 595492 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10935

Kim S.H., Fountoulakis M., Cairns N., Lubec G.

J. Neural Transm. Suppl. 2001:223-235(2001) GeneRIF 10935 · Mapped (8)
Protein levels of Prx-III a mitochondrial protein were significantly decreased in Alzheimer Disease and Down Syndrome. GeneRIF 10935

Rabilloud T., Heller M., Gasnier F., Luche S., Rey C., Aebersold R., Benahmed M., Louisot P., Lunardi J.

J. Biol. Chem. 277:19396-19401(2002) GeneRIF 10935 · UniProtKB (1) · Mapped (8)
Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site GeneRIF 10935

Wonsey D.R., Zeller K.I., Dang C.V.

Proc. Natl. Acad. Sci. U.S.A. 99:6649-6654(2002) GeneRIF 10935 · Mapped (9)
PRDX3 is a c-Myc target gene that is requried to maintain normal mitochondrial function. c-Myc directly activates expression of a mitochondrial peroxiredoxin that is required for Myc-mediated transformation. GeneRIF 10935

Shen C., Nathan C.

Mol. Med. 8:95-102(2002) GeneRIF 10935 · Mapped (9)
2-Cys Prxs act in a mutually nonredundant and sometimes stress-specific fashion to protect human cells from oxidant injury. The substantial resistance of human cells to hydroperoxides may result in part from the additive action of multiple Prxs GeneRIF 10935

Choi J.H., Kim T.N., Kim S., Baek S.H., Kim J.H., Lee S.R., Kim J.R.

Anticancer Res. 22:3331-3335(2002) GeneRIF 10935 · Mapped (6)
Mitochondrial thioredoxin reductase and peroxiredoxin III are overexpressed in hepatocellular carcinomas. GeneRIF 10935

Krapfenbauer K., Engidawork E., Cairns N., Fountoulakis M., Lubec G.

Brain Res. 967:152-160(2003) GeneRIF 10935 · Mapped (10)
The level of peroxiredoxin 3 is decreased in the frontal cortex of patients with Down syndrome and Pick's disease. GeneRIF 10935

Chang T.S., Cho C.S., Park S., Yu S., Kang S.W., Rhee S.G.

J. Biol. Chem. 279:41975-41984(2004) GeneRIF 10935 · Mapped (6)
Peroxiredoxin III is a critical regulator of the abundance of mitochondrial H(2)O(2) which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling GeneRIF 10935

Liu L., Yang C., Yuan J., Chen X., Xu J., Wei Y., Yang J., Lin G., Yu L.

Mol. Cells 19:39-45(2005) GeneRIF 10935 · Mapped (10)
findings indicate that RPK118 is a PRDX3-binding protein that may be involved in transporting PRDX3 from the cytoplasm to its mitochondrial site of function or to other membrane structures via endosome trafficking. GeneRIF 10935

Grupe A., Li Y., Rowland C., Nowotny P., Hinrichs A.L., Smemo S., Kauwe J.S., Maxwell T.J., Cherny S., Doil L. et al.

Am. J. Hum. Genet. 78:78-88(2006) GeneRIF 10935 GAD 595494 · Mapped (1,497)
Not Associated with NEUROLOGICAL: Alzheimer's disease ; GAD 595494 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10935

Zhang H., Go Y.M., Jones D.P.

Arch. Biochem. Biophys. 465:119-126(2007) GeneRIF 10935 · Mapped (8)
The additive protection by Trx2 and GSH shows that Trx2 and GSH systems are both functionally important at low oxidative stress conditions. GeneRIF 10935

Yang H.Y., Jeong D.K., Kim S.H., Chung K.J., Cho E.J., Yang U., Lee S.R., Lee T.H.

Biochem. Biophys. Res. Commun. 359:1030-1036(2007) GeneRIF 10935 · Mapped (6)
Finally the expression level of beta-globin and GATA-1 was dramatically increased in Prdx III O/E cell line. GeneRIF 10935

Lee W., Wells T., Kantorow M.

Mol. Vis. 13:1469-1474(2007) GeneRIF 10935 · Mapped (6)
Present throughout lens and localized to mitochondria in lens epithelial cells. Induction is acute response of lens to increased H2O2. Important role in lens H2O2-detoxification mitochondrial maintenance and possibly cataract formation. GeneRIF 10935

Chiribau C.B., Cheng L., Cucoranu I.C., Yu Y.S., Clempus R.E., Sorescu D.

J. Biol. Chem. 283:8211-8217(2008) GeneRIF 10935 · Mapped (10)
FOXO3A mediates Prx III expression and this may play a critical role in the resistance to oxidative stress in cardiac fibroblasts GeneRIF 10935

Feng Y., Liu D.Q., Wang Z., Liu Z., Cao H.Q., Wang L.Y., Shi N., Meng X.M.

Biochemistry Mosc. 72:1199-1204(2007) GeneRIF 10935 · Mapped (7)
coexpression of AOP-1 inhibited TNNI3K kinase activity GeneRIF 10935

De Simoni S., Goemaere J., Knoops B.

Neurosci. Lett. 433:219-224(2008) GeneRIF 10935 · Mapped (8)
Our results show that mitochondrial PRDX-depleted cells are more prone to oxidative damages and apoptosis induced by MPP(+) a complex I inhibitor which provides an experimental paradigm of Parkinson's disease. GeneRIF 10935

Jurkunas U.V., Rawe I., Bitar M.S., Zhu C., Harris D.L., Colby K., Joyce N.C.

Invest. Ophthalmol. Vis. Sci. 49:2956-2963(2008) GeneRIF 10935 · Mapped (8)
Significantly decreased expression of Prx-2 -3 and -5 in FED may suggest an alteration in the ability of endothelial cells to withstand oxidant-induced damage and may be closely related to the pathogenesis of this disease. GeneRIF 10935

Chen L., Na R., Gu M., Salmon A.B., Liu Y., Liang H., Qi W., Van Remmen H., Richardson A., Ran Q.

Aging Cell 7:866-878(2008) GeneRIF 10935 · Mapped (6)
As a result of increased Prdx3 transgene expression mitochondria from transgenic mice produce a significantly reduced amount of hydrogen peroxide and cells from transgenic (PRDX3) mice have increased resistance to stress-induced cell death and apoptosis. GeneRIF 10935

Myers C.R., Myers J.M.

Toxicology 257:95-104(2009) GeneRIF 10935 · Mapped (10)
Report the effects of acrolein on peroxiredoxins thioredoxins and thioredoxin reductase in human bronchial epithelial cells. GeneRIF 10935

Noh Y.H., Baek J.Y., Jeong W., Rhee S.G., Chang T.S.

J. Biol. Chem. 284:8470-8477(2009) GeneRIF 10935 · Mapped (6)
Srx plays a crucial role in the reactivation of sulfinic mitochondrial Prx III and that its mitochondrial translocation is critical in maintaining the balance between mitochondrial H(2)O(2) production and elimination GeneRIF 10935

Kim K., Yu M., Han S., Oh I., Choi Y.J., Kim S., Yoon K., Jung M., Choe W.

Oncol. Rep. 21:1391-1396(2009) GeneRIF 10935 · Mapped (6)
Conclude that Prx II and III are upregulated in response to the development of cervical cancer. GeneRIF 10935

Aerts G., Arrojo E Drigo R., Van Herck S.L., Sammels E., Mirebeau-Prunier D., Gereben B., Zeold A., Harney J.W., Huang S.A., Mulcahey M.A. et al.

Endocrinology 150:5171-5180(2009) GeneRIF 10935 · Mapped (8)
Prx3 knockdown resulted in a 50% decrease in D3-mediated whole-cell deiodination. GeneRIF 10935

Chua P.J., Lee E.H., Yu Y., Yip G.W., Tan P.H., Bay B.H.

Int. J. Oncol. 36:359-364(2010) GeneRIF 10935 · Mapped (6)
Peroxiredoxin III has a significant role in cell cycle regulation and could be a potential proliferation marker in breast cancer. GeneRIF 10935

Davila S., Froeling F.E., Tan A., Bonnard C., Boland G.J., Snippe H., Hibberd M.L., Seielstad M.

Genes Immun. 11:232-238(2010) GeneRIF 10935 · Mapped (4,258)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 10935