Rasmussen S.K., Urhammer S.A., Pizzuti A., Echwald S.M., Ekstrom C.T., Hansen L., Hansen T., Borch-Johnsen K., Frittitta L., Trischitta V. et al.

Diabetes 49:1608-1611(2000) GAD 132392 · Mapped (5)
Not Associated with METABOLIC: diabetes, type 2; GAD 132392

Tarnow L., Grarup N., Hansen T., Parving H.H., Pedersen O.

Nephrol. Dial. Transplant. 16:1653-1656(2001) GAD 132390 GAD 132391 · Mapped (11)
Not Associated with OTHER: Diabetic microvascular complications; GAD 132390 GAD 132391

De Cosmo S., Miscio G., Zucaro L., Margaglione M., Argiolas A., Thomas S., Piras G., Trevisan R., Perin P.C., Bacci S. et al.

Nephrol. Dial. Transplant. 17:1402-1407(2002) GAD 132398 GeneRIF 5122 · Mapped (17)
Associated with RENAL: nephropathy, diabetic; GAD 132398 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) GeneRIF 5122

Deftos L.J., Burton D., Hastings R.H., Terkeltaub R., Hook V.Y.

Endocrine 15:217-224(2001) GeneRIF 5122 · Mapped (7)
prominently expressed in PTHrP-expressing human cancer cell lines originating from tumors of the breast lung prostate as well as lymphoma GeneRIF 5122

Frittitta L., Baratta R., Spampinato D., Di Paola R., Pizzuti A., Vigneri R., Trischitta V.

J. Clin. Endocrinol. Metab. 86:5888-5891(2001) GeneRIF 5122 · Mapped (5)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 5122

de Azevedo M.J., Dalmaz C.A., Caramori M.L., Pecis M., Esteves J.F., Maia A.L., Gross J.L.

J. Diabetes Complicat. 16:255-262(2002) GeneRIF 5122 · Mapped (17)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5122

Jacobsen P., Grarup N., Tarnow L., Parving H.H., Pedersen O.

Nephrol. Dial. Transplant. 17:1408-1412(2002) GeneRIF 5122 · Mapped (9)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5122

Wanic K., Malecki M., Klupa T., Witek P., Kozek E., Sieradzki J.

Prz. Lek. 59:888-891(2002) GeneRIF 5122 · Mapped (15)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5122

Baratta R., Di Paola R., Spampinato D., Fini G., Marucci A., Coco A., Vigneri R., Frittitta L., Trischitta V.

J. Mol. Med. 81:718-723(2003) GeneRIF 5122 · Mapped (32)
Polymorphism associated with insulin resistance affects insulin snssitivity by interacting with PPARgamma2. GeneRIF 5122

Winsky-Sommerer R., Grouselle D., Rougeot C., Laurent V., David J.P., Delacourte A., Dournaud P., Seidah N.G., Lindberg I., Trottier S. et al.

Neuroscience 122:437-447(2003) GeneRIF 5122 · Mapped (7)
PC1 is present in the human cortex to fulfill its role in proteolytic processing of neuropeptide precursors; no significant change in PC1 levels is observed in Alzheimer patients. GeneRIF 5122

Kubaszek A., Markkanen A., Eriksson J.G., Forsen T., Osmond C., Barker D.J., Laakso M.

J. Clin. Endocrinol. Metab. 89:2044-2047(2004) GeneRIF 5122 · Mapped (9)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5122

Laukkanen O., Pihlajamaki J., Lindstrom J., Eriksson J., Valle T.T., Hamalainen H., Ilanne-Parikka P., Keinanen-Kiukaanniemi S., Tuomilehto J., Uusitupa M. et al.

Diabetologia 47:871-877(2004) GeneRIF 5122 · Mapped (17)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5122

Stettler H., Suri G., Spiess M.

Biochemistry 44:5339-5345(2005) GeneRIF 5122 · Mapped (5)
results have implications for the mechanism of granule sorting of PC3 as well as for the topology of PC2 and carboxypeptidase E which have been reported to span the lipid membrane by homologous charged sequences GeneRIF 5122

Tzimas G.N., Chevet E., Jenna S., Nguyen D.T., Khatib A.M., Marcus V., Zhang Y., Chretien M., Seidah N., Metrakos P.

BMC Cancer 5:149-149(2005) GeneRIF 5122 · Mapped (7)
PC1 and PC2 in are abnormally expressed and processed in human colorectal liver metastases GeneRIF 5122

Lloyd D.J., Bohan S., Gekakis N.

Hum. Mol. Genet. 15:1884-1893(2006) GeneRIF 5122 · Mapped (7)
PC1 has a role in obesity hyperphagia and increased metabolic efficiency GeneRIF 5122

Costacou T., Chang Y., Ferrell R.E., Orchard T.J.

Am. J. Epidemiol. 164:862-872(2006) GeneRIF 5122 · Mapped (64)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5122

Tateno T., Izumiyama H., Doi M., Akashi T., Ohno K., Hirata Y.

Endocr. J. 54:777-782(2007) GeneRIF 5122 · Mapped (5)
defective PC1/3 expression may lead to preferential production of unprocessed biologically inactive ACTH variants in sient corticotroph adenoma. GeneRIF 5122

Park S., Han T., Son T., Kang H.S.

Int J Sports Med 29:294-299(2008) GeneRIF 5122 · Mapped (5)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 5122

Rehfeld J.F., Bundgaard J.R., Hannibal J., Zhu X., Norrbom C., Steiner D.F., Friis-Hansen L.

Endocrinology 149:1600-1608(2008) GeneRIF 5122 · Mapped (18)
PC1/3 governs the endocrine and PC2 the neuronal processing of proCCK whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22. GeneRIF 5122

Lankat-Buttgereit B., Muller S., Schmidt H., Parhofer K.G., Gress T.M., Goke R.

Biol. Cell 100:703-715(2008) GeneRIF 5122 · Mapped (13)
Suppression of Pdcd4 resulted in an increased release of CgA and Sg II and was accompanied by an up-regulation of intracellular PC1. GeneRIF 5122

Wen J.H., Chen Y.Y., Song S.J., Ding J., Gao Y., Hu Q.K., Feng R.P., Liu Y.Z., Ren G.C., Zhang C.Y. et al.

Diabetologia 52:504-513(2009) GeneRIF 5122 · Mapped (35)
Function for PAX6 in the regulation of proinsulin processing and glucose metabolism via modulation of PC1/3 production. GeneRIF 5122

GIANT Consortium
Renstrom F., Payne F., Nordstrom A., Brito E.C., Rolandsson O., Hallmans G., Barroso I., Nordstrom P., Franks P.W.

Hum. Mol. Genet. 18:1489-1496(2009) GeneRIF 5122 · Mapped (28)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5122

Fuller J.A., Brun-Zinkernagel A.M., Clark A.F., Wordinger R.J.

Invest. Ophthalmol. Vis. Sci. 50:5759-5768(2009) GeneRIF 5122 · Mapped (10)
PC1 and PC2 were primarily expressed in neurons whereas PACE4 appeared to be largely restricted to glia. Thus elevated PACE4 may modulate the bioactivity of proteins secreted in the ONH and retina. GeneRIF 5122

Kilpelainen T.O., Bingham S.A., Khaw K.T., Wareham N.J., Loos R.J.

Hum. Mol. Genet. 18:3496-3501(2009) GeneRIF 5122 GAD 594258 · Mapped (5)
Not Associated with METABOLIC: Obesity; GAD 594258 Observational study of gene-disease association. (HuGE Navigator); PCSK1 rs6232 and rs6235 SNPs are not major contributors to common obesity in the general population; however the effect of rs6232 may be age-dependent. GeneRIF 5122

Takahashi T., Ida T., Sato T., Nakashima Y., Nakamura Y., Tsuji A., Kojima M.

J. Biochem. 146:675-682(2009) GeneRIF 5122 · Mapped (22)
The presence of PC and GOAT in the cells as well as n-octanoic acid in the culture medium was necessary to produce n-octanoyl ghrelin. GeneRIF 5122