| Mullerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation. Laurich V.M., Trbovich A.M., O'Neill F.H., Houk C.P., Sluss P.M., Payne A.H., Donahoe P.K., Teixeira J.
Endocrinology 143:3351-3360(2002) GeneRIF 13074 · Mapped (5)
cAMP induces expression of Cyp17 by a PKA-mediated mechanism which is inhibited by MIS signal transduction GeneRIF 13074 |
| The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion. Chaturvedi G., Arai K., Terranova P.F., Roby K.F.
Mol. Cell. Biochem. 318:191-200(2008) GeneRIF 13074 · Mapped (8)
These results implicate Src tyrosine kinase in the regulation of CYP17 and thecal androgen secretion. GeneRIF 13074 |
| Regulation of P450c17 expression in the early embryo depends on GATA factors. Shi Y., Schonemann M.D., Mellon S.H.
Endocrinology 150:946-956(2009) GeneRIF 13074 · Mapped (12)
P450c17 is expressed in mouse embryonic stem cells its expression increases upon differentiation to an early embryonic endoderm lineage. GeneRIF 13074 |
| Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse. Morohashi K., Tsuboi-Asai H., Matsushita S., Suda M., Nakashima M., Sasano H., Hataba Y., Li C.L., Fukata J., Irie J. et al.
Blood 93:1586-1594(1999) MGI 88586 · Mapped (31) |
| Early neocortical regionalization in the absence of thalamic innervation. Miyashita-Lin E.M., Hevner R., Wassarman K.M., Martinez S., Rubenstein J.L.
Science 285:906-909(1999) MGI 88586 · Mapped (30) |
| Scraggly, a new hair loss mutation on mouse chromosome 19. Herron B.J., Bryda E.C., Heverly S.A., Collins D.N., Flaherty L.
Mamm. Genome 10:864-869(1999) MGI 88586 · Mapped (16) |
| Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis. Compagnone N.A., Zhang P., Vigne J.L., Mellon S.H.
Mol. Endocrinol. 14:875-888(2000) MGI 88586 · Mapped (7) |
| A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice. Rieger D.K., Reichenberger E., McLean W., Sidow A., Olsen B.R.
Genomics 72:61-72(2001) MGI 88586 · Mapped (27) |
| Mapping murine loci for physical dependence on ethanol. Buck K.J., Rademacher B.S., Metten P., Crabbe J.C.
Psychopharmacology (Berl.) 160:398-407(2002) MGI 88586 · Mapped (17) |
| Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Tevosian S.G., Albrecht K.H., Crispino J.D., Fujiwara Y., Eicher E.M., Orkin S.H.
Development 129:4627-4634(2002) MGI 88586 · UniProtKB (1) · Mapped (74) |
| Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production. Heikkila M., Peltoketo H., Leppaluoto J., Ilves M., Vuolteenaho O., Vainio S.
Endocrinology 143:4358-4365(2002) MGI 88586 · Mapped (21) |
| Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species. Arlt W., Martens J.W., Song M., Wang J.T., Auchus R.J., Miller W.L.
Endocrinology 143:4665-4672(2002) MGI 88586 · UniProtKB (3) · Mapped (3) |
| Sexually dimorphic gene expression in the developing mouse gonad. Menke D.B., Page D.C.
Gene Expr. Patterns 2:359-367(2002) MGI 88586 · UniProtKB (8) · Mapped (73) |
| Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Choudhary D., Jansson I., Schenkman J.B., Sarfarazi M., Stoilov I.
Arch. Biochem. Biophys. 414:91-100(2003) MGI 88586 · Mapped (99) |
| Isolation and characterization of the mouse P450 17 alpha-hydroxylase/C17-20-lyase gene (Cyp17): transcriptional regulation of the gene by cyclic adenosine 3',5'-monophosphate in MA-10 Leydig cells. Youngblood G.L., Payne A.H.
Mol. Endocrinol. 6:927-934(1992) MGI 88586 · Mapped (3) |
| Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz B.P., Abuin A., Ramirez-Solis R., Richter L.J., Piggott J., BeltrandelRio H., Buxton E.C., Edwards J., Finch R.A., Friddle C.J. et al.
Proc. Natl. Acad. Sci. U.S.A. 100:14109-14114(2003) MGI 88586 · Mapped (23,055) |
| Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha V.K., Bunkenborg J., Olsen J.V., Hjerrild M., Wisniewski J.R., Stahl E., Bolouri M.S., Ray H.N., Sihag S., Kamal M. et al.
Cell 115:629-640(2003) MGI 88586 · UniProtKB (15) · Mapped (1,215) |
| Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding. Fan Y.S., Sasi R., Lee C., Winter J.S., Waterman M.R., Lin C.C.
Genomics 14:1110-1111(1992) MGI 88586 · Mapped (3) |
| Deletion of the mouse P450c17 gene causes early embryonic lethality. Bair S.R., Mellon S.H.
Mol. Cell. Biol. 24:5383-5390(2004) MGI 88586 · Mapped (3) |
| Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Bouma G.J., Hart G.T., Washburn L.L., Recknagel A.K., Eicher E.M.
Gene Expr. Patterns 5:141-149(2004) MGI 88586 · Mapped (179) |
| Niemann pick type C disease as a model for defects in neurosteroidogenesis. Mellon S., Gong W., Griffin L.D.
Endocr. Res. 30:727-735(2004) MGI 88586 · Mapped (3) |
| Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. Liu Y., Yao Z.X., Papadopoulos V.
Mol. Endocrinol. 19:1918-1931(2005) MGI 88586 GeneRIF 13074 · Mapped (4)
CYP17 in addition to its 17alpha-hydroxylase/17 20-lyase activity critical in androgen formation also expresses a secondary activity squalene monooxygenase (epoxidase). GeneRIF 13074 |
| Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development. Park S.Y., Meeks J.J., Raverot G., Pfaff L.E., Weiss J., Hammer G.D., Jameson J.L.
Development 132:2415-2423(2005) MGI 88586 · Mapped (38) |
| Haploinsufficiency of cytochrome P450 17alpha-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice. Liu Y., Yao Z.X., Bendavid C., Borgmeyer C., Han Z., Cavalli L.R., Chan W.Y., Folmer J., Zirkin B.R., Haddad B.R. et al.
Mol. Endocrinol. 19:2380-2389(2005) MGI 88586 GeneRIF 13074 · UniProtKB (1) · Mapped (3)
CYP17 deletion causes infertility in male. GeneRIF 13074 |
| Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Bouma G.J., Albrecht K.H., Washburn L.L., Recknagel A.K., Churchill G.A., Eicher E.M.
Development 132:3045-3054(2005) MGI 88586 · Mapped (135) |
in citationmapping
