Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D.

J. Immunol. 168:671-679(2002) GeneRIF 22914 · UniProtKB (2) · Mapped (2)
NKG2D is the receptor for UL16-binding proteins expressed on primary natural killer cells. GeneRIF 22914

Groh V., Wu J., Yee C., Spies T.

Nature 419:734-738(2002) GeneRIF 22914 · UniProtKB (1) · Mapped (58)
binding of MICA and MICB induces endocytosis and downregulation of NKG2D and in turn severe impairment of the responsiveness of tumour-antigen-specific effector T cells GeneRIF 22914

Welte S.A., Sinzger C., Lutz S.Z., Singh-Jasuja H., Sampaio K.L., Eknigk U., Rammensee H.G., Steinle A.

Eur. J. Immunol. 33:194-203(2003) GeneRIF 22914 · Mapped (2)
Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein. GeneRIF 22914

Castriconi R., Cantoni C., Della Chiesa M., Vitale M., Marcenaro E., Conte R., Biassoni R., Bottino C., Moretta L., Moretta A.

Proc. Natl. Acad. Sci. U.S.A. 100:4120-4125(2003) GeneRIF 22914 · Mapped (8)
Expression of this receptor inhibited by TGF-beta1 affects NK-mediated killing of dendritic cells GeneRIF 22914

Chalupny N.J., Sutherland C.L., Lawrence W.A., Rein-Weston A., Cosman D.

Biochem. Biophys. Res. Commun. 305:129-135(2003) GeneRIF 22914 · UniProtKB (1) · Mapped (2)
ULBP4 is a novel ligand for NKG2D (ULBP4) GeneRIF 22914

Hue S., Monteiro R.C., Berrih-Aknin S., Caillat-Zucman S.

J. Immunol. 171:1909-1917(2003) GeneRIF 22914 · UniProtKB (1) · Mapped (50)
In the thymus NKG2D may be a signal allowing newly matured CD8+ T cells to emigrate to the periphery; in thymomas there is a decreased percentage of NKG2D-positive thymocytes which express a less mature phenotype than in normal thymus. GeneRIF 22914

Raulet D.H.

Nat. Rev. Immunol. 3:781-790(2003) GeneRIF 22914 · Mapped (6)
NKG2D signalling enhances innate and adaptive immune responses (review) GeneRIF 22914

Eleme K., Taner S.B., Onfelt B., Collinson L.M., McCann F.E., Chalupny N.J., Cosman D., Hopkins C., Magee A.I., Davis D.M.

J. Exp. Med. 199:1005-1010(2004) GeneRIF 22914 · Mapped (51)
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. GeneRIF 22914

Lanier L.L.

J. Biol. Regul. Homeost. Agents 17:338-340(2003) GeneRIF 22914 · Mapped (2)
NKG2D structure ligands function and tissue distribution (review) GeneRIF 22914

Verneris M.R., Karami M., Baker J., Jayaswal A., Negrin R.S.

Blood 103:3065-3072(2004) GeneRIF 22914 · Mapped (2)
NKG2D triggering accounts for the majority of major histocompatibility complex (MHC)-unrestricted cytotoxicity of activated and expanded CD8+ T cells likely through DAP10-mediated signaling. GeneRIF 22914

Lee J.C., Lee K.M., Kim D.W., Heo D.S.

J. Immunol. 172:7335-7340(2004) GeneRIF 22914 · Mapped (11)
incubation of NK cells and LAK cells with TGF-beta1 resulted in dramatic reduction of surface NKG2D expression associated with impaired NK cytotoxicity GeneRIF 22914

Carbone E., Neri P., Mesuraca M., Fulciniti M.T., Otsuki T., Pende D., Groh V., Spies T., Pollio G., Cosman D. et al.

Blood 105:251-258(2005) GeneRIF 22914 · Mapped (3)
natural cytotoxicity receptor (NCR) and NK receptor member D of the lectin-like receptor family (NKG2D) were the key NK activating receptors for bone marrow-derived myeloma cell recognition GeneRIF 22914

Zhang B., Wei H., Zheng X., Zhang J., Sun R., Tian Z.

Peptides 26:405-412(2005) GeneRIF 22914 · Mapped (71)
analysis of functional sites in NKG2D-MICA interaction in mouse and human GeneRIF 22914

Nowbakht P., Ionescu M.C., Rohner A., Kalberer C.P., Rossy E., Mori L., Cosman D., De Libero G., Wodnar-Filipowicz A.

Blood 105:3615-3622(2005) GeneRIF 22914 · Mapped (6)
NKG2D NKp30 NKp44 and NKp46 acitvation affected by ligand-negative phenotype in bone marrow-derived progenitor cells acquisition of cell-surface ligands during myeloid differentiation defective expression of ligands on malignant transformation GeneRIF 22914

Ehrlich L.I., Ogasawara K., Hamerman J.A., Takaki R., Zingoni A., Allison J.P., Lanier L.L.

J. Immunol. 174:1922-1931(2005) GeneRIF 22914 · Mapped (6)
NKG2D engagement by ligand or monoclonal antibody is not sufficient to costimulate naive or effector CD8+ T cell responses in conventional T cell populations. GeneRIF 22914

Nikitina-Zake L., Rajalingham R., Rumba I., Sanjeevi C.B.

Ann. N. Y. Acad. Sci. 1037:161-169(2004) GeneRIF 22914 · Mapped (702)
Polymorphic MICA in HLA Class I interacts with non-polymorphic NKG2d receptor on NK cells. GeneRIF 22914

Maasho K., Opoku-Anane J., Marusina A.I., Coligan J.E., Borrego F.

J. Immunol. 174:4480-4484(2005) GeneRIF 22914 · Mapped (2)
NKG2D serves as a costimulatory receptor for TCR induced Ca2+ mobilization and proliferation in naive CD8+ T cells GeneRIF 22914

Clayton A., Tabi Z.

Blood Cells Mol. Dis. 34:206-213(2005) GeneRIF 22914 · Mapped (2)
tumor exosome-phenotype showed positive expression of several NKG2D ligands important in driving the reduction in the proportion of NKG2D-positive effector cells GeneRIF 22914

Rincon-Orozco B., Kunzmann V., Wrobel P., Kabelitz D., Steinle A., Herrmann T.

J. Immunol. 175:2144-2151(2005) GeneRIF 22914 · Mapped (2)
Remarkable similarities in NKG2D function in natural killer (NK) and Vgamma9 Vdelta2 T cells may open new perspectives for Vgamma9 Vdelta2 T cell-based immunotherapy GeneRIF 22914

Dann S.M., Wang H.C., Gambarin K.J., Actor J.K., Robinson P., Lewis D.E., Caillat-Zucman S., White A.C. Jr.

J. Infect. Dis. 192:1294-1302(2005) GeneRIF 22914 · Mapped (2)
expression increased by Il-15 in NK cells GeneRIF 22914

Forte P., Lilienfeld B.G., Baumann B.C., Seebach J.D.

J. Immunol. 175:5463-5470(2005) GeneRIF 22914 · Mapped (3)
Freshly isolated natural killer (NK) cells lyse porcine endothelial cells exclusively in an NKG2D-dependent fashion; lysis of porcine endothelial cells mediated by activated human NK cells depends on both NKp44 and NKG2D GeneRIF 22914

Guilloton F., de Thonel A., Jean C., Demur C., Mansat-De Mas V., Laurent G., Quillet-Mary A.

Leukemia 19:2206-2214(2005) GeneRIF 22914 · Mapped (8)
acute myeloid leukemia cells expressed the NKG2D receptor and its signal-transducing adaptator DAP 10 which were functional as confirmed by redirected lysis experiments GeneRIF 22914

Poggi A., Prevosto C., Massaro A.M., Negrini S., Urbani S., Pierri I., Saccardi R., Gobbi M., Zocchi M.R.

J. Immunol. 175:6352-6360(2005) GeneRIF 22914 · Mapped (4)
NKG2D/MHC-I-related stress-inducible molecule A and/or NKG2D/UL-16 binding protein 3 engagement is responsible for the delivery of a lethal hit GeneRIF 22914

Schreiner B., Voss J., Wischhusen J., Dombrowski Y., Steinle A., Lochmuller H., Dalakas M., Melms A., Wiendl H.

FASEB J. 20:118-120(2006) GeneRIF 22914 · Mapped (12)
The role of TLR3 in the immunobiology of muscle is reported; its implications for the understanding of the pathogenesis of inflammatory myopathies or therapeutic interventions are included. GeneRIF 22914

Azimi N., Jacobson S., Tanaka Y., Corey L., Groh V., Spies T.

Immunogenetics 58:252-258(2006) GeneRIF 22914 · Mapped (59)
Engagement of MIC by NKG2D promotes spontaneous HAM/TSP T cell proliferation and apparently CTL activities against HTLV-1-infected T cells. GeneRIF 22914