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Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance.

Aganna E., Aksentijevich I., Hitman G.A., Kastner D.L., Hoepelman A.I., Posma F.D., Zweers E.J., McDermott M.F.

Eur. J. Hum. Genet. 9:63-66(2001) GAD 136964 · Mapped (4)
Associated with IMMUNE: Tumor necrosis factor receptor-associated periodic syndrome; GAD 136964

Lack of evidence for an association between two genetic polymorphisms in the tumor necrosis factor receptor 1 gene and multiple sclerosis in Ashkenazi Jews.

Pras E., Aksentijevich I., Shinar Y., Kastner D.L., Achiron A.

Eur. Neurol. 46:153-155(2001) GAD 136959 GAD 136965 GeneRIF 7132 · Mapped (4)
Not Associated with IMMUNE: Multiple Sclerosis; GAD 136959 Not Associated with IMMUNE: multiple sclerosis; GAD 136965 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Polymorphisms in the TNF-alpha and TNF-receptor genes in patients with coronary artery disease.

Allen R.A., Lee E.M., Roberts D.H., Park B.K., Pirmohamed M.

Eur. J. Clin. Invest. 31:843-851(2001) GAD 136982 GeneRIF 7132 · Mapped (17)
Not Associated with CARDIOVASCULAR: coronary artery disease; GAD 136982 Observational study and meta-analysis of gene-disease association. (HuGE Navigator) GeneRIF 7132

Polymorphisms of the tumor necrosis factor receptors: no association with narcolepsy in German patients.

Wieczorek S., Dahmen N., Jagiello P., Epplen J.T., Gencik M.

J. Mol. Med. 81:87-90(2003) GAD 136985 GeneRIF 7132 · Mapped (17)
Not Associated with IMMUNE: narcolepsy; GAD 136985 Observational study of gene-disease association. (HuGE Navigator); Polymorphism not associated with narcolepsy. GeneRIF 7132

A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients.

Vendrell J., Fernandez-Real J.M., Gutierrez C., Zamora A., Simon I., Bardaji A., Ricart W., Richart C.

Atherosclerosis 167:257-264(2003) GAD 136962 GeneRIF 7132 · Mapped (10)
(-308) TNF-alpha gene polymorphism may contribute to CHD risk in patients with type 2 diabetes and can be useful predictive marker for the diagnosis of CHD in type 2 diabetic women. GeneRIF 7132 Associated with METABOLIC: diabetes, type 2; GAD 136962

No association of polymorphisms in the tumor necrosis factor receptor I and receptor II genes with disease severity in rheumatoid arthritis.

Glossop J.R., Nixon N.B., Dawes P.T., Hassell A.B., Mattey D.L.

J. Rheumatol. 30:1406-1409(2003) GAD 136971 GeneRIF 7132 · Mapped (11)
Not Associated with IMMUNE: arthritis; GAD 136971 Observational study of gene-disease association. (HuGE Navigator); Neither the +36 TNFRSF1A SNP nor the +196 TNFRSF1B SNP is associated with RA severity in a population of Caucasian patients with RA. GeneRIF 7132

A TNFR1 genotype with a protective role in familial rheumatoid arthritis.

European Consortium on Rheumatoid Arthritis Families
Dieude P., Osorio J., Petit-Teixeira E., Moreno S., Garnier S., Cailleau-Moindrault S., Stalens C., Lasbleiz S., Bardin T., Prum B. et al.

Arthritis Rheum. 50:413-419(2004) GAD 136963 GeneRIF 7132 · Mapped (11)
Associated with IMMUNE: Rheumatoid Arthritis; TNFR2 GAD 136963 Distribution of the TNFR2 196 R/R and TNFR1 +36 A/A genotypes in familial rheumatoid arthritis could suggest an interaction between TNFR1 and TNFR2 in the genetic susceptibility for rheumatoid arthritis; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) GeneRIF 7132

Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis.

Aganna E., Hawkins P.N., Ozen S., Pettersson T., Bybee A., McKee S.A., Lachmann H.J., Karenko L., Ranki A., Bakkaloglu A. et al.

Genes Immun. 5:289-293(2004) GAD 136989 GeneRIF 7132 · Mapped (14)
Associated with METABOLIC: amyloidosis; GAD 136989 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Promoter polymorphisms of tumor necrosis factor-alpha are associated with risk of gastric mucosa-associated lymphoid tissue lymphoma.

Wu M.S., Chen L.T., Shun C.T., Huang S.P., Chiu H.M., Wang H.P., Lin M.T., Cheng A.L., Lin J.T.

Int. J. Cancer 110:695-700(2004) GAD 136990 GeneRIF 7132 · Mapped (20)
Associated with CANCER: lymphoma; GAD 136990 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.

Gordon A.C., Lagan A.L., Aganna E., Cheung L., Peters C.J., McDermott M.F., Millo J.L., Welsh K.I., Holloway P., Hitman G.A. et al.

Genes Immun. 5:631-640(2004) GAD 136986 GeneRIF 7132 · Mapped (17)
Not Associated with INFECTION: sepsis; GAD 136986 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Association of the R92Q TNFRSF1A mutation and extracranial deep vein thrombosis in patients with Behcet's disease.

Amoura Z., Dode C., Hue S., Caillat-Zucman S., Bahram S., Delpech M., Grateau G., Wechsler B., Piette J.C.

Arthritis Rheum. 52:608-611(2005) GAD 136975 GeneRIF 7132 · Mapped (4)
Associated with CARDIOVASCULAR: thrombosis, deep vein; Behcet's disease; GAD 136975 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis.

Glossop J.R., Dawes P.T., Nixon N.B., Mattey D.L.

Arthritis Res. Ther. 7:R1227-34(2005) GAD 136973 GeneRIF 7132 · Mapped (11)
Associated with IMMUNE: rheumatoid arthritis; GAD 136973 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis.

Stanke F., Becker T., Cuppens H., Kumar V., Cassiman J.J., Jansen S., Radojkovic D., Siebert B., Yarden J., Ussery D.W. et al.

Hum. Genet. 119:331-343(2006) GAD 154658 GeneRIF 7132 · Mapped (20)
Associated with OTHER: cystic fibrosis; GAD 154658 TNFRSF1A is a modulation in Cystic Fibrosis; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Determination of genetic predisposition to patent ductus arteriosus in preterm infants.

Dagle J.M., Lepp N.T., Cooper M.E., Schaa K.L., Kelsey K.J., Orr K.L., Caprau D., Zimmerman C.R., Steffen K.M., Johnson K.J. et al.

Pediatrics 123:1116-1123(2009) GAD 561061 GeneRIF 7132 · Mapped (1,774)
Not Associated with REPRODUCTION: patent ductus arteriosus; GAD 561061 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

International MS Genetics Consortium
De Jager P.L., Jia X., Wang J., de Bakker P.I., Ottoboni L., Aggarwal N.T., Piccio L., Raychaudhuri S., Tran D., Aubin C. et al.

Nat. Genet. 41:776-782(2009) GAD 599874 GAD 599875 GeneRIF 7132 · Mapped (1,336)
Associated with IMMUNE: multiple sclerosis; GAD 599874 GAD 599875 Replication in an independent set of 2 215 subjects with multiple sclerosis (MS) and 2 116 control subjects validates new MS susceptibility loci at TNFRSF1A IRF8 and CD6; TNFRSF1A harbors two independent susceptibility alleles; Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Lack of association between tumour necrosis factor receptor types 1 and 2 gene polymorphism and severe acute alcoholic hepatitis.

Nguyen-Khac E., Houchi H., Daoust M., Dupas J.L., Naassila M.

Eur J Gastroenterol Hepatol 22:794-800(2010) GAD 561050 GeneRIF 7132 · Mapped (11)
Not Associated with CHEMDEPENDENCY: alcohol; GAD 561050 Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator); These results did not support an association between 36 TNFR1 676 TNFR2 gene polymorphisms and acute alcoholic hepatitis. GeneRIF 7132

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

Hosgood H.D., Zhang L., Shen M., Berndt S.I., Vermeulen R., Li G., Yin S., Yeager M., Yuenger J., Rothman N. et al.

Occup Environ Med 66:848-853(2009) GAD 561047 GeneRIF 7132 · Mapped (1,047)
Not Associated with PHARMACOGENOMIC: benzene haematotoxicity; GAD 561047 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.

Young R.P., Hopkins R.J., Hay B.A., Epton M.J., Mills G.D., Black P.N., Gardner H.D., Sullivan R., Gamble G.D.

Postgrad Med J 85:515-524(2009) GAD 561045 GeneRIF 7132 · Mapped (832)
Associated with CANCER: lung cancer ; GAD 561045 Observational study of gene-disease association gene-gene interaction and gene-environment interaction. (HuGE Navigator) GeneRIF 7132

Genetic analysis of immunomodulating factors in sporadic Parkinson's disease.

Kruger R., Hardt C., Tschentscher F., Jackel S., Kuhn W., Muller T., Werner J., Woitalla D., Berg D., Kuhnl N. et al.

J Neural Transm 107:553-562(2000) GeneRIF 7132 · Mapped (15)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy.

Nishimura M., Maeda M., Matsuoka M., Mine H., Saji H., Matsui M., Kuroda Y., Kawakami H., Uchiyama T.

Hum. Immunol. 61:1262-1269(2000) GeneRIF 7132 · Mapped (339)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 7132

Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infection.

Yee L.J., Tang J., Herrera J., Kaslow R.A., van Leeuwen D.J.

Genes Immun. 1:386-390(2000) GeneRIF 7132 · Mapped (26)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 7132

Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians.

Barton A., John S., Ollier W.E., Silman A., Worthington J.

Arthritis Rheum. 44:61-65(2001) GeneRIF 7132 GAD 136968 · Mapped (11)
Not Associated with IMMUNE: arthritis; GAD 136968 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7132

Different allelic frequencies of several cytokine genes in Hong Kong Chinese and Swedish Caucasians.

Padyukov L., Hahn-Zoric M., Lau Y.L., Hanson L.A.

Genes Immun. 2:280-283(2001) GeneRIF 7132 · Mapped (26)
Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 7132

Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases.

Amrani Y., Ammit A.J., Panettieri R.A. Jr.

Mol. Pharmacol. 60:646-655(2001) GeneRIF 7132 · Mapped (5)
Despite the presence of functional TNFR2 TNFR1 associated with MAPK-dependent and -independent pathways is the primary signaling pathway involved in TNF alpha-induced synthetic functions in ASM cells. GeneRIF 7132

Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.

De Wilde G., Mertens N., Boone E., De Vreese B., Van Beeumen J., Fiers W., Haegeman G.

Protein Expr. Purif. 23:226-232(2001) GeneRIF 7132 · Mapped (4)
Here we report the expression and purification of the human TNF-RI DD as a fusion with the Escherichia coli thioredoxin A (TRX) protein GeneRIF 7132

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