Zheng X.M., Resnick R.J., Shalloway D.

J. Biol. Chem. 277:21922-21929(2002) GeneRIF 19262 · Mapped (3)
Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation GeneRIF 19262

van der Wijk T., Blanchetot C., Overvoorde J., den Hertog J.

J. Biol. Chem. 278:13968-13974(2003) GeneRIF 19262 · Mapped (9)
RPTPs have the capacity for inside-out signaling GeneRIF 19262

Brandt D.T., Goerke A., Heuer M., Gimona M., Leitges M., Kremmer E., Lammers R., Haller H., Mischak H.

J. Biol. Chem. 278:34073-34078(2003) GeneRIF 19262 · Mapped (17)
protein tyrosine phosphatase PTP alpha has a role in induction of src kinase via protein kinase C GeneRIF 19262

Petrone A., Battaglia F., Wang C., Dusa A., Su J., Zagzag D., Bianchi R., Casaccia-Bonnefil P., Arancio O., Sap J.

EMBO J. 22:4121-4131(2003) GeneRIF 19262 MGI 97808 · Mapped (33)
RPTRalpha is essential for hippocampal neuronal migration and long-term potentiation. GeneRIF 19262

Skelton M.R., Ponniah S., Wang D.Z., Doetschman T., Vorhees C.V., Pallen C.J.

Brain Res. 984:1-10(2003) GeneRIF 19262 MGI 97808 · Mapped (3)
PTPalpha knockout mice show decreased anxiety without an increase in head dips and stretch-attend movements; during Morris water maze learning PTPalpha-/- mice have increased latencies to reach the goal but no memory deficit on probe trials. GeneRIF 19262

Bodrikov V., Leshchyns'ka I., Sytnyk V., Overvoorde J., den Hertog J., Schachner M.

J. Cell Biol. 168:127-139(2005) GeneRIF 19262 · Mapped (17)
Data show that the NCAM140 isoform directly interacts with the intracellular domain of the receptor-like protein tyrosine phosphatase RPTPalpha a known activator of p59fyn GeneRIF 19262

Tiran Z., Peretz A., Sines T., Shinder V., Sap J., Attali B., Elson A.

Mol. Biol. Cell 17:4330-4342(2006) GeneRIF 19262 MGI 97808 · Mapped (7)
We conclude that PTPepsilon and PTPalpha differ significantly in their regulation of Kv channels and Src in the system examined and that similarity between PTPs does not necessarily result in full functional redundancy in vivo. GeneRIF 19262

Le H.T., Maksumova L., Wang J., Pallen C.J.

J. Neurochem. 98:1798-1809(2006) GeneRIF 19262 · Mapped (12)
Defective NMDAR activity in protein tyrosine phosphatase alpha(PTPalpha) deficiency may be linked to loss of PTPalpha as upstream regulator of proline-rich tyrosine kinase 2. GeneRIF 19262

Yang J., Groen A., Lemeer S., Jans A., Slijper M., Roe S.M., den Hertog J., Barford D.

Biochemistry 46:709-719(2007) GeneRIF 19262 · Mapped (3)
Exposure of RPTPalpha D2 to oxidants promotes formation of a cyclic sulfenamide species a reversibly oxidized state of Cys723 accompanied by conformational changes of the D2 catalytic site. GeneRIF 19262

Niu X.L., Li J., Hakim Z.S., Rojas M., Runge M.S., Madamanchi N.R.

J. Biol. Chem. 282:19808-19819(2007) GeneRIF 19262 · Mapped (15)
LAR regulates IGF-1R signaling in vascular smooth muscle cells GeneRIF 19262

Maksumova L., Wang Y., Wong N.K., Le H.T., Pallen C.J., Johnson P.

J. Biol. Chem. 282:20925-20932(2007) GeneRIF 19262 · Mapped (10)
PTPalpha and PTPalpha-Y789F have distinct activities in T cells and CD45 is a regulator of PTPalpha phosphorylation at tyrosine 789 in T cells GeneRIF 19262

Kostic A., Sap J., Sheetz M.P.

J. Cell. Sci. 120:3895-3904(2007) GeneRIF 19262 MGI 97808 · Mapped (3)
Data show that RPTPalpha is required for rigidity-dependent reinforcement of fibronectin (FN)-cytoskeleton bonds and the rigidity response in hippocampal neuron growth cones. GeneRIF 19262

Ye H., Tan Y.L., Ponniah S., Takeda Y., Wang S.Q., Schachner M., Watanabe K., Pallen C.J., Xiao Z.C.

EMBO J. 27:188-200(2008) GeneRIF 19262 MGI 97808 MINT MINT-129698 MINT MINT-129698 MINT MINT-129698 MINT MINT-129698 · Mapped (35)
MINT-6439905. Chl1 (uniprotkb:P70232) physically interacts (MI:0915) with Ptpa (uniprotkb:P18052) by anti tag coimmunoprecipitation (MI:0007). From mint MINT MINT-129698 MINT-6439918. Ptpa (uniprotkb:P18052) physically interacts (MI:0915) with Chl1 (uniprotkb:P70232) by anti tag coimmunoprecipitation (MI:0007). From mint MINT MINT-129698 MINT-6439931. Ptpa (uniprotkb:P18052) physically interacts (MI:0915) with Chl1 (uniprotkb:P70232) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-129698 MINT-6439945. Ptpa (uniprotkb:P18052) and Chl1 (uniprotkb:P70232) colocalize (MI:0403) by fluorescence microscopy (MI:0416). From mint MINT MINT-129698 Mediates close homolog of L1 (CHL1) and contactin-6 (NB-3)-regulated apical dendrite projection in the developing caudal cortex. GeneRIF 19262

Huang J., Huang A., Zhang Q., Lin Y.C., Yu H.G.

J. Biol. Chem. 283:29912-29919(2008) GeneRIF 19262 · Mapped (11)
RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation GeneRIF 19262

Bodrikov V., Sytnyk V., Leshchyns'ka I., den Hertog J., Schachner M.

J. Cell Biol. 182:1185-1200(2008) GeneRIF 19262 · Mapped (19)
Data show that cell surface clustering of neural cell adhesion molecule (NCAM) is coupled to increased serine phosphorylation and RPTPalpha activity and results in the activation of NCAM-associated calmodulin-dependent protein kinase IIalpha. GeneRIF 19262

Vacaresse N., Moller B., Danielsen E.M., Okada M., Sap J.

J. Biol. Chem. 283:35815-35824(2008) GeneRIF 19262 · Mapped (4)
Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization. GeneRIF 19262

Chen S.C., Khanna R.S., Bessette D.C., Samayawardhena L.A., Pallen C.J.

Am. J. Physiol., Cell Physiol. 297:C133-9(2009) GeneRIF 19262 MGI 97808 · Mapped (21)
Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration. GeneRIF 19262

Wang Q., Rajshankar D., Branch D.R., Siminovitch K.A., Herrera Abreu M.T., Downey G.P., McCulloch C.A.

J. Biol. Chem. 284:20763-20772(2009) GeneRIF 19262 · Mapped (15)
PTPalpha acts as an adaptor to mediate functional links between focal adhesions and the endoplasmic reticulum that enable IL-1-induced Ca2+ signaling. GeneRIF 19262

Vacaru A.M., den Hertog J.

Mol. Cell. Biol. 30:2850-2861(2010) GeneRIF 19262 MGI 97808 · Mapped (7)
A new model for mitotic activation of Src in which PP2A-mediated dephosphorylation of RPTPalpha pSer204 facilitates Src binding is proposed. GeneRIF 19262

Wang Q., Rajshankar D., Laschinger C., Talior-Volodarsky I., Wang Y., Downey G.P., McCulloch C.A.

J. Biol. Chem. 285:22308-22317(2010) GeneRIF 19262 · Mapped (28)
IL-1-induced signaling through focal adhesions leading to MMP3 release and interactions between SHP-2 and PTPalpha are dependent on the integrity of the catalytic domains of PTPalpha. GeneRIF 19262

Wu Z., Yates A.L., Hoyne G.F., Goodnow C.C.

J. Immunol. 185:231-238(2010) GeneRIF 19262 · Mapped (17)
Expression of CD45RA and -RC isoforms is increased 20- to 200-fold on T cells from mice with a loss-of-function mutation in RNA-binding protein heterogeneous nuclear ribonucleoprotein L-like although total CD45 expression is unaltered. GeneRIF 19262

Tremper-Wells B., Resnick R.J., Zheng X., Holsinger L.J., Shalloway D.

Genes Cells 15:711-724(2010) GeneRIF 19262 MGI 97808 · Mapped (3)
The results suggest that transformation by PTPalpha involves at least one function other than or in addition to its activation of Src and that this depends on PTPalpha's extracellular domain. GeneRIF 19262

Buitrago C., Costabel M., Boland R.

Mol. Cell. Endocrinol. 339:81-89(2011) GeneRIF 19262 MGI 97808 · Mapped (6)
protein kinase C and protein tyrosine phosphatase alpha participate in Src activation by 1alpha 25OH2 vitamin D3 in C2C12 skeletal muscle cells GeneRIF 19262

Ye H., Zhao T., Tan Y.L., Liu J., Pallen C.J., Xiao Z.C.

J. Biol. Chem. 286:26071-26080(2011) GeneRIF 19262 · Mapped (9)
the PTPalpha-mediated increase of NB-3 level at the cell surface represents a novel function of PTPalpha in NB-3 signaling in neural development GeneRIF 19262

Sun G., Cheng S.Y., Chen M., Lim C.J., Pallen C.J.

Mol. Cell. Biol. 32:3776-3789(2012) GeneRIF 19262 MGI 97808 · Mapped (10)
study described a molecular complex of PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas localization to focal adhesions and Cas downstream signaling to promote cell migration GeneRIF 19262