Tang T., Arbiser J.L., Brandt S.J.

J. Biol. Chem. 277:18365-18372(2002) GeneRIF 6886 · UniProtKB (1) · Mapped (4)
role of hypoxia in stimulating phosphorylation ubiquitination and proteasomal breakdown in endothelial cells GeneRIF 6886

Sinclair A.M., Bench A.J., Bloor A.J., Li J., Gottgens B., Stanley M.L., Miller J., Piltz S., Hunter S., Nacheva E.P. et al.

Blood 99:3931-3938(2002) GeneRIF 6886 · Mapped (7)
SCL locus can rescue knockout scl(-/-) mice GeneRIF 6886

Goardon N., Schuh A., Hajar I., Ma X., Jouault H., Dzierzak E., Romeo P.H., Maouche-Chretien L.

Blood 100:491-500(2002) GeneRIF 6886 · Mapped (7)
Ectopic expression of human TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation but did not cause leukemia. GeneRIF 6886

Lecuyer E., Herblot S., Saint-Denis M., Martin R., Begley C.G., Porcher C., Orkin S.H., Hoang T.

Blood 100:2430-2440(2002) GeneRIF 6886 · Mapped (15)
regulates c-kit expression in hematopoietic cells through functional interaction with Sp1 GeneRIF 6886

Zeuner A., Eramo A., Testa U., Felli N., Pelosi E., Mariani G., Srinivasula S.M., Alnemri E.S., Condorelli G., Peschle C. et al.

Cell Death Differ. 10:905-913(2003) GeneRIF 6886 · Mapped (4)
is a survival factor for erythroid cells GeneRIF 6886

Hansson A., Manetopoulos C., Jonsson J.I., Axelson H.

Biochem. Biophys. Res. Commun. 312:1073-1081(2003) GeneRIF 6886 · Mapped (4)
These results indicate that TAL1 can affect both T cell proliferation and differentiation. GeneRIF 6886

Ravet E., Reynaud D., Titeux M., Izac B., Fichelson S., Romeo P.H., Dubart-Kupperschmitt A., Pflumio F.

Blood 103:3326-3335(2004) GeneRIF 6886 · Mapped (4)
Enforced expression of a TAL1 protein deleted of its DNA-binding domain mimicked most TAL1 effects except for the LTC-IC enhancement the down-regulation of the CD34 surface marker and the GPA(+) cell production GeneRIF 6886

Lazrak M., Deleuze V., Noel D., Haouzi D., Chalhoub E., Dohet C., Robbins I., Mathieu D.

J. Cell. Sci. 117:1161-1171(2004) GeneRIF 6886 · Mapped (4)
TAL-1 modulates the angiogenic response of endothelial cells by stimulating cell morphogenesis and by influencing their behavior in migration. GeneRIF 6886

Dekel B., Hochman E., Sanchez M.J., Maharshak N., Amariglio N., Green A.R., Izraeli S.

Kidney Int. 65:1162-1169(2004) GeneRIF 6886 · Mapped (4)
Possible role for SCL in renal vasculogenesis. Undifferentiated mesenchymal cells expressing SCL during early nephrogenesis might represent putative progenitors that can simultaneously give rise to kidney blood and endothelium. GeneRIF 6886

Wen J., Huang S., Pack S.D., Yu X., Brandt S.J., Noguchi C.T.

J. Biol. Chem. 280:12956-12966(2005) GeneRIF 6886 · Mapped (4)
Tal1/SCL binding to pericentromeric DNA represses transcription GeneRIF 6886

Delabesse E., Ogilvy S., Chapman M.A., Piltz S.G., Gottgens B., Green A.R.

Mol. Cell. Biol. 25:5215-5225(2005) GeneRIF 6886 · Mapped (4)
Results show striking coexpression of SCL and its immediate downstream neighbor MAP17 suggesting that they share regulatory elements. GeneRIF 6886

Reynaud D., Ravet E., Titeux M., Mazurier F., Renia L., Dubart-Kupperschmitt A., Romeo P.H., Pflumio F.

Blood 106:2318-2328(2005) GeneRIF 6886 · Mapped (4)
TAL1 expression level regulates immature human hematopoietic cell self-renewal and this regulation requires TAL1 DNA-binding activity GeneRIF 6886

Le Clech M., Chalhoub E., Dohet C., Roure V., Fichelson S., Moreau-Gachelin F., Mathieu D.

J. Mol. Biol. 355:9-19(2006) GeneRIF 6886 · Mapped (6)
PU.1 in addition to its positive role in TAL-1 expression in early hematopoietic progenitors may also act as a mediator of TAL-1 silencing in some hematopoietic lineages GeneRIF 6886

Palomero T., Odom D.T., O'Neil J., Ferrando A.A., Margolin A., Neuberg D.S., Winter S.S., Larson R.S., Li W., Liu X.S. et al.

Blood 108:986-992(2006) GeneRIF 6886 · Mapped (4)
TAL1 may act as a bifunctional transcriptional regulator (activator and repressor) at the top of a complex regulatory network that disrupts normal T-cell homeostasis and contributes to leukemogenesis. GeneRIF 6886

McCormack M.P., Hall M.A., Schoenwaelder S.M., Zhao Q., Ellis S., Prentice J.A., Clarke A.J., Slater N.J., Salmon J.M., Jackson S.P. et al.

Blood 108:2248-2256(2006) GeneRIF 6886 · Mapped (9)
Scl acts up-stream of NF-E2 expression to control megakaryocyte development and platelet release in settings of thrombopoietic stress GeneRIF 6886

Chang P.Y., Draheim K., Kelliher M.A., Miyamoto S.

Cancer Res. 66:6008-6013(2006) GeneRIF 6886 · Mapped (5)
TAL1 modulates NFKB1 expression and an NF-kappaB-dependent transcriptional program in a subset of human T-cell leukemia cells. GeneRIF 6886

Brunet de la Grange P., Armstrong F., Duval V., Rouyez M.C., Goardon N., Romeo P.H., Pflumio F.

Blood 108:2998-3004(2006) GeneRIF 6886 · Mapped (7)
Using lentiviral delivery of TAL1-directed shRNA in human hematopoietic cells showed that decreased expression of TAL1 induced major disorders at different levels of adult hematopoietic cell development GeneRIF 6886

Cheng Y., Zhang Z., Slape C., Aplan P.D.

Neoplasia 9:315-321(2007) GeneRIF 6886 · Mapped (10)
Conditional activation of the SCL transgene under control of ubiquitously expressed SCL interrupting locus (SIL) transgenic regulatory elements impairs normal T-cell development. GeneRIF 6886

Fasseu M., Aplan P.D., Chopin M., Boissel N., Bories J.C., Soulier J., von Boehmer H., Sigaux F., Regnault A.

Blood 110:2610-2619(2007) GeneRIF 6886 · Mapped (10)
CD3epsilon-mediated signal transduction pathway is essential for this transformation process GeneRIF 6886

Lecuyer E., Lariviere S., Sincennes M.C., Haman A., Lahlil R., Todorova M., Tremblay M., Wilkes B.C., Hoang T.

J. Biol. Chem. 282:33649-33658(2007) GeneRIF 6886 · Mapped (9)
the SCL-LMO2 interaction couples protein stabilization with higher order protein complex assembly thus providing a powerful means of modulating the stoichiometry and spatiotemporal activity of SCL complexes GeneRIF 6886

Ryan D.P., Duncan J.L., Lee C., Kuchel P.W., Matthews J.M.

Proteins 70:1461-1474(2008) GeneRIF 6886 · Mapped (8)
characterize the assembly of a five-component complex containing TAL1 LMO2 Ldb1 E12 and DNA. The bHLH domains of TAL1 and E12 alone primarily formed helical homodimers but together formed heterodimers to which LMO2 bound with high affinity GeneRIF 6886

Nie L., Wu H., Sun X.H.

J. Biol. Chem. 283:684-692(2008) GeneRIF 6886 · UniProtKB (1) · Mapped (6)
Operation of cullin-based ubiquitin ligase complexes and potential means by which Notch and Tal1/SCL regulate eukaryotic development. GeneRIF 6886

Zhang M., Swanson P.C.

J. Biol. Chem. 283:6717-6727(2008) GeneRIF 6886 · Mapped (13)
LMO2 TAL1 Ttg-1 and SIL support levels of V(D)J recombination above background levels in cell culture and are also cleaved by the RAG proteins while Hox11 and SCL are nicked but not cleaved efficiently in vitro GeneRIF 6886

Brunet de la Grange P., Zink E., Armstrong F., Rouyez M.C., Pflumio F.

Stem Cells 26:1658-1662(2008) GeneRIF 6886 · Mapped (4)
Data definitively delineate the human myeloid progenitors that are regulated by TAL1. GeneRIF 6886

Terme J.M., Wencker M., Favre-Bonvin A., Bex F., Gazzolo L., Duc Dodon M., Jalinot P.

J. Virol. 82:7913-7922(2008) GeneRIF 6886 · Mapped (4)
analysis of cross talk between the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1 GeneRIF 6886