Kebache S., Zuo D., Chevet E., Larose L.

Proc. Natl. Acad. Sci. U.S.A. 99:5406-5411(2002) GeneRIF 4690 · Mapped (6)
Modulation of protein translation by Nck-1. GeneRIF 4690

Scaplehorn N., Holmstrom A., Moreau V., Frischknecht F., Reckmann I., Way M.

Curr. Biol. 12:740-745(2002) GeneRIF 4690 · Mapped (6)
Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus GeneRIF 4690

Okabe S., Fukuda S., Broxmeyer H.E.

Exp. Hematol. 30:761-766(2002) GeneRIF 4690 · Mapped (32)
The association of NCK with Wiskott-Aldrich syndrome protein is associated with cell migration in stromal cell-derived factor-1alpha-stimulated Jurkat cells GeneRIF 4690

Eden S., Rohatgi R., Podtelejnikov A.V., Mann M., Kirschner M.W.

Nature 418:790-793(2002) GeneRIF 4690 · UniProtKB (1) · Mapped (9)
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck: we propose that Rac1 and Nck cause dissociation of the WAVE1 complex which releases active WAVE1-HSPC300 and leads to actin nucleation. GeneRIF 4690

Lim C.S., Kim S.H., Jung J.G., Kim J.K., Song W.K.

J. Biol. Chem. 278:52116-52123(2003) GeneRIF 4690 · Mapped (11)
the interaction of the betaPIX.WASP.SPIN90 complex with Nck is crucial for stable cell adhesion and can be dynamically modulated by SPIN90 phosphorylation that is dependent on cell adhesion and ERK activation GeneRIF 4690

Campellone K.G., Rankin S., Pawson T., Kirschner M.W., Tipper D.J., Leong J.M.

J. Cell Biol. 164:407-416(2004) GeneRIF 4690 · UniProtKB (1) · Mapped (6)
Data show that clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. GeneRIF 4690

Stoletov K.V., Gong C., Terman B.I.

Exp. Cell Res. 295:258-268(2004) GeneRIF 4690 · Mapped (10)
Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in cell migration. GeneRIF 4690

Miyamoto Y., Yamauchi J., Mizuno N., Itoh H.

J. Biol. Chem. 279:34336-34342(2004) GeneRIF 4690 · Mapped (9)
Nck1 mediates endothelin A receptor-regulated cell migration through the Cdc42-dependent c-Jun N-terminal kinase pathway GeneRIF 4690

Verma R., Kovari I., Soofi A., Nihalani D., Patrie K., Holzman L.B.

J. Clin. Invest. 116:1346-1359(2006) GeneRIF 4690 · Mapped (17)
nephrin phosphorylation results in Src kinase activation recruitment of Nck and assembly of actin filaments in an Nck-dependent fashion GeneRIF 4690

Lettau M., Qian J., Linkermann A., Latreille M., Larose L., Kabelitz D., Janssen O.

Proc. Natl. Acad. Sci. U.S.A. 103:5911-5916(2006) GeneRIF 4690 · Mapped (5)
FasL-associated adaptor protein Nck is involved in the actin-dependent transport of FasL-bearing secretory lysosomes to the mimunological synapse. GeneRIF 4690

Frese S., Schubert W.D., Findeis A.C., Marquardt T., Roske Y.S., Stradal T.E., Heinz D.W.

J. Biol. Chem. 281:18236-18245(2006) GeneRIF 4690 PDB 2CI9 PDB 2CI8 · UniProtKB (1) · Mapped (6)
Nck1 (Nckalpha) and Nck2 (Nckbeta and Grb4): binding specificities of both SH2 domains are essentially indistinguishable GeneRIF 4690

Boyle E.C., Brown N.F., Brumell J.H., Finlay B.B.

Microbiology (Reading, Engl.) 153:3517-3526(2007) GeneRIF 4690 · Mapped (16)
the adaptors Nck and ShcA influenced adherence of S. Typhimurium to non-phagocytic cells. GeneRIF 4690

Cardin E., Latreille M., Khoury C., Greenwood M.T., Larose L.

FEBS J. 274:5865-5875(2007) GeneRIF 4690 · Mapped (2)
overexpression of Nck in mammalian cells fails to attenuate eIF2alphaSer51 phosphorylation in response to amino acid starvation a stress well known to activate GCN2 GeneRIF 4690

Bai L., Schuller S., Whale A., Mousnier A., Marches O., Wang L., Ooka T., Heuschkel R., Torrente F., Kaper J.B. et al.

Infect. Immun. 76:361-368(2008) GeneRIF 4690 · UniProtKB (1) · Mapped (2)
Enteropathogenic Escherichia coli O125:H6 lacks the ability to utilize either Nck or TccP/TccP2 and hence triggers actin polymerization in vitro only inefficiently. GeneRIF 4690

Blasutig I.M., New L.A., Thanabalasuriar A., Dayarathna T.K., Goudreault M., Quaggin S.E., Li S.S., Gruenheid S., Jones N., Pawson T.

Mol. Cell. Biol. 28:2035-2046(2008) GeneRIF 4690 · Mapped (4)
Any of 3 phosphorylated YDXV nephrin motifs is sufficient to recruit Nck via its SH2 domain & induce localized actin polymerization. Nck SH3 mutants in which only the 2d or 3d SH3 domain is functional can mediate nephrin-induced actin polymerization. GeneRIF 4690

Cardin E., Larose L.

Biochem. Biophys. Res. Commun. 377:231-235(2008) GeneRIF 4690 · Mapped (9)
These data provide the first evidence identifying Nck-1 as a novel endogenous regulator of PKR and support the notion that Nck-1-PKR interaction could be a way to limit PKR activation. GeneRIF 4690

Santiveri C.M., Borroto A., Simon L., Rico M., Alarcon B., Jimenez M.A.

Biochim. Biophys. Acta 1794:110-117(2009) GeneRIF 4690 PDB 2JW4 MINT MINT-92747 MINT MINT-92747 MINT MINT-92747 · Mapped (3)
Based on NMR data CD3-epsilon-derived peptides bind Nckalpha SH3.1 through a PxxPxRDY motif that combines specific stabilising interactions corresponding to both canonical class II PxxPx(K/R) and non-canonical PxxPxxDY motifs GeneRIF 4690 MINT-7233971. CD3 epsilon (uniprotkb:P07766) and NCK alpha (uniprotkb:P16333) bind (MI:0407) by nuclear magnetic resonance (MI:0077). From mint MINT MINT-92747 MINT-7233987. NCK alpha (uniprotkb:P16333) binds (MI:0407) to CD3 epsilon (uniprotkb:P07766) by enzyme linked immunosorbent assay (MI:0411). From mint MINT MINT-92747 MINT-7234008. NCK alpha (uniprotkb:P16333) binds (MI:0407) to CD3 epsilon (uniprotkb:P07766) by enzyme linked immunosorbent assay (MI:0411). From mint MINT MINT-92747

Guan S., Fan J., Han A., Chen M., Woodley D.T., Li W.

J. Invest. Dermatol. 129:1909-1920(2009) GeneRIF 4690 · Mapped (13)
independent roles and mechanisms of action of Nckalpha and Nckbeta in dermal fibroblast migration which is critical for wound healing. GeneRIF 4690

Preisinger C., Kolch W.

Cell. Signal. 22:848-856(2010) GeneRIF 4690 · Mapped (30)
The results show that Bcr-Abl regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76/Nck1 adaptor protein pathway. GeneRIF 4690

Gehmlich K., Hayess K., Legler C., Haebel S., Van der Ven P.F., Ehler E., Furst D.O.

Eur. J. Cell Biol. 89:351-364(2010) GeneRIF 4690 · Mapped (19)
The novel ponsin isoform and its interaction with Nck1/2 provide exciting insight into the convergence of signalling pathways at the costameres and its crucial role for skeletal muscle differentiation and re-generation. GeneRIF 4690

Davila S., Froeling F.E., Tan A., Bonnard C., Boland G.J., Snippe H., Hibberd M.L., Seielstad M.

Genes Immun. 11:232-238(2010) GeneRIF 4690 · Mapped (4,258)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 4690

Flachsbart F., Franke A., Kleindorp R., Caliebe A., Blanche H., Schreiber S., Nebel A.

Mutat. Res. 694:13-19(2010) GeneRIF 4690 · Mapped (1,167)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 4690

Oser M., Dovas A., Cox D., Condeelis J.

Eur. J. Cell Biol. 90:181-188(2011) GeneRIF 4690 · Mapped (6)
Nck1 specifically localizes to invadopodia but not to podosomes formed in macrophages or degradative structures formed in Src-transformed fibroblasts and PMA-stimulated endothelial cells. GeneRIF 4690

Shen S.L., Qiu F.H., Dayarathna T.K., Wu J., Kuang M., Li S.S., Peng B.G., Nie J.

Biochim. Biophys. Acta 1812:703-710(2011) GeneRIF 4690 · Mapped (3)
Mass spectrometry analysis revealed a group of Nck1 SH2 domain-binding proteins that were differentially expressed in HCC. One of these proteins dermcidin (DCD). GeneRIF 4690

Pauker M.H., Reicher B., Fried S., Perl O., Barda-Saad M.

Mol. Cell. Biol. 31:2653-2666(2011) GeneRIF 4690 · Mapped (6)
a functional cooperation between Nck and ADAP in stabilizing the recruitment of WASp to SLP76 regulates actin rearrangement. GeneRIF 4690