Fujii K., Fujii Y., Hubscher S., Tanaka Y.

J. Immunol. 167:1198-1203(2001) GeneRIF 960 · Mapped (6)
Interaction of CD44 when cross-linked on rheumatoid synovial cells with hyaluronan fragments present in the surrounding extracellular matrix augments Fas expression and Fas-mediated apoptosis of synovial cells. GeneRIF 960

Akiyama Y., Jung S., Salhia B., Lee S., Hubbard S., Taylor M., Mainprize T., Akaishi K., van Furth W., Rutka J.T.

J. Neurooncol. 53:115-127(2001) GeneRIF 960 · Mapped (12)
Hyaluronate receptors mediate glioma cell migration and proliferation. The expression of the HA-receptors CD44 and RHAMM is virtually ubiquitous amongst glioma cell lines and glioma tumor specimens. GeneRIF 960

Poncelet C., Walker F., Madelenat P., Bringuier A.F., Scoazec J.Y., Feldmann G., Darai E.

Hum. Pathol. 32:1190-1196(2001) GeneRIF 960 · Mapped (6)
Expression in uterine smooth muscle tumors GeneRIF 960

Cywes C., Wessels M.R.

Nature 414:648-652(2001) GeneRIF 960 · Mapped (6)
cd44 dependent group A Streptococcus binding to keratinocytes induce cytoskeletal rearrangements GeneRIF 960

Afify A.M., Ferguson A.W., Davila R.M., Werness B.A.

Appl. Immunohistochem. Mol. Morphol. 9:309-314(2001) GeneRIF 960 · Mapped (6)
results suggest that CD44S and CD44v5 are differentially expressed in early and advanced ovarian serous carcinomas and support previous studies that suggest a role for CD44 and stromal hyaluronic acid in the dissemination of ovarian epithelial cancer GeneRIF 960

Niitsu N., Iijima K.

Leuk. Res. 26:241-248(2002) GeneRIF 960 · Mapped (6)
sCD44 levels could be a useful prognostic marker for aggressive lymphoma GeneRIF 960

Jain A., Karadag A., Fohr B., Fisher L.W., Fedarko N.S.

J. Biol. Chem. 277:13700-13708(2002) GeneRIF 960 · Mapped (20)
Three SIBLINGs (small integrin-binding ligand N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack. GeneRIF 960

Okamoto I., Tsuiki H., Kenyon L.C., Godwin A.K., Emlet D.R., Holgado-Madruga M., Lanham I.S., Joynes C.J., Vo K.T., Guha A. et al.

Am. J. Pathol. 160:441-447(2002) GeneRIF 960 · Mapped (6)
wide prevalence of CD44 cleavage suggests that it plays an important role in the pathogenesis of human tumors GeneRIF 960

Van Driel M., Gunthert U., van Kessel A.C., Joling P., Stauder R., Lokhorst H.M., Bloem A.C.

Leukemia 16:135-143(2002) GeneRIF 960 · Mapped (6)
variant isoforms involved in plasma cell adhesion to bone marrow stromal cells and in the multiple myeloma disease process GeneRIF 960

Teder P., Vandivier R.W., Jiang D., Liang J., Cohn L., Pure E., Henson P.M., Noble P.W.

Science 296:155-158(2002) GeneRIF 960 · Mapped (18)
In mice CD44 plays a role in resolving the inflammatory response following lung injury by clearance of inflammatory hyaluronan fragments clearance of apoptotic PMNs and generation of active TGFbeta 1. GeneRIF 960

Barshishat M., Ariel A., Cahalon L., Chowers Y., Lider O., Schwartz B.

Clin. Exp. Metastasis 19:327-337(2002) GeneRIF 960 · Mapped (13)
TNFalpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells. GeneRIF 960

Mori H., Tomari T., Koshikawa N., Kajita M., Itoh Y., Sato H., Tojo H., Yana I., Seiki M.

EMBO J. 21:3949-3959(2002) GeneRIF 960 · Mapped (11)
CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. GeneRIF 960

Bourguignon L.Y., Singleton P.A., Zhu H., Zhou B.

J. Biol. Chem. 277:39703-39712(2002) GeneRIF 960 · Mapped (10)
CD44 interaction with the TGF-betaRI kinase promotes activation of multiple signaling pathways required for ankyrin-membrane interaction tumor cell migration and oncogenic events during HA and TGF-beta-mediated metastatic breast tumor progression GeneRIF 960

Yasuda M., Nakano K., Yasumoto K., Tanaka Y.

Histol. Histopathol. 17:945-950(2002) GeneRIF 960 · Mapped (6)
CD44 has a functional role in inflammatory processes and tumor susceptibility GeneRIF 960

Suzuki M., Kobayashi H., Kanayama N., Nishida T., Takigawa M., Terao T.

Biochim. Biophys. Acta 1591:37-44(2002) GeneRIF 960 · Mapped (28)
a signal transduction cascade or cross-talk emanating from CD44 to c-Met GeneRIF 960

Lafont F., Tran Van Nhieu G., Hanada K., Sansonetti P., van der Goot F.G.

EMBO J. 21:4449-4457(2002) GeneRIF 960 · Mapped (6)
Initial steps of Shigella binding and cell entry depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction. GeneRIF 960

Lammich S., Okochi M., Takeda M., Kaether C., Capell A., Zimmer A.K., Edbauer D., Walter J., Steiner H., Haass C.

J. Biol. Chem. 277:44754-44759(2002) GeneRIF 960 · Mapped (6)
Data suggest that intramembranous processing of CD44 occurs by a presenilin-1-dependent gamma-secretase activity at two distinct sites. GeneRIF 960

Cichy J., Bals R., Potempa J., Mani A., Pure E.

J. Biol. Chem. 277:44440-44447(2002) GeneRIF 960 · Mapped (6)
CD44 spontaneously released from normal bronchial epithelial cells can accumulate as an integral component of the matrix where it may play a role in the organization of matrices and in anchoring growth factors and chemokines to the matrix GeneRIF 960

Spessotto P., Rossi F.M., Degan M., Di Francia R., Perris R., Colombatti A., Gattei V.

J. Cell Biol. 158:1133-1144(2002) GeneRIF 960 · Mapped (13)
Hyaluronan-CD44 interaction inhibits migration of osteoclast-like cells by down-regulating MMP-9. GeneRIF 960

Fujita Y., Kitagawa M., Nakamura S., Azuma K., Ishii G., Higashi M., Kishi H., Hiwasa T., Koda K., Nakajima N. et al.

FEBS Lett. 528:101-108(2002) GeneRIF 960 · Mapped (15)
Engagement of CD44 either by its natural ligand hyaluronan or a specific antibody on a cell line induced tyrosine phosphorylation and activation of focal adhesion kinase. GeneRIF 960

Assimakopoulos D., Kolettas E., Patrikakos G., Evangelou A.

Histol. Histopathol. 17:1269-1281(2002) GeneRIF 960 · Mapped (18)
reduction in the expression of CD44 may confer growth advantage and malignant properties to tumour cells GeneRIF 960

Dohadwala M., Batra R.K., Luo J., Lin Y., Krysan K., Pold M., Sharma S., Dubinett S.M.

J. Biol. Chem. 277:50828-50833(2002) GeneRIF 960 · Mapped (13)
Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates antigen in cox-2-dependent invasion GeneRIF 960

Hayes G.M., Chiu R., Carpenito C., Dougherty S.T., Dougherty G.J.

J. Biol. Chem. 277:50529-50534(2002) GeneRIF 960 · Mapped (6)
exon v10-encoded B[X(7)] GeneRIF 960

Hogerkorp C.M., Bilke S., Breslin T., Ingvarsson S., Borrebaeck C.A.

Blood 101:2307-2313(2003) GeneRIF 960 · Mapped (6)
results show that genes such as interleukin-6 (IL-6) IL-1alpha and beta(2)-adrenergic receptor (beta(2)-AR) were specifically up-regulated by CD44 ligation suggesting a novel role for CD44 in immunoregulation and inflammation GeneRIF 960

Barshishat M., Levi I., Benharroch D., Schwartz B.

Br. J. Cancer 87:1314-1320(2002) GeneRIF 960 · Mapped (6)
Butyrate significantly inhibited transcription of the CD44 gene and abolished epidermal growth factor-mediated up-regulation of the reporter gene luciferase subcloned upstream to the CD44 promoter (-1.1 kb) and transfected to HM7 cells GeneRIF 960