Buning C., Ockenga J., Kruger S., Jurga J., Baier P., Dignass A., Vogel A., Strassburg C., Weltrich R., Genschel J. et al.

Scand. J. Gastroenterol. 38:538-542(2003) GAD 129477 GeneRIF 3938 · Mapped (1)
Not Associated with IMMUNE: Crohn's disease; ulcerative colitis; GAD 129477 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3938

Rasinpera H., Forsblom C., Enattah N.S., Halonen P., Salo K., Victorzon M., Mecklin J.P., Jarvinen H., Enholm S., Sellick G. et al.

Gut 54:643-647(2005) GAD 129483 GeneRIF 3938 · Mapped (1)
Associated with CANCER: colorectal cancer; GAD 129483 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3938

Kerber M., Oberkanins C., Kriegshauser G., Kollerits B., Dossenbach-Glaninger A., Fuchs D., Ledochowski M.

Clin. Chim. Acta 383:91-96(2007) GAD 150659 GeneRIF 3938 · Mapped (1)
Associated with METABOLIC: lactose intolerance; GAD 150659 Observational study of gene-disease association and genetic testing. (HuGE Navigator) GeneRIF 3938

Jacob R., Peters K., Naim H.Y.

J. Biol. Chem. 277:8217-8225(2002) GeneRIF 3938 · Mapped (1)
These data clearly demonstrate that the proregion of pro-LPH is an intramolecular chaperone that is critically essential in facilitating the folding of the intermediate form LPH beta(initial) in the context of the pro-LPH polypeptide. GeneRIF 3938

van Wering H.M., Huibregtse I.L., van der Zwan S.M., de Bie M.S., Dowling L.N., Boudreau F., Rings E.H., Grand R.J., Krasinski S.D.

J. Biol. Chem. 277:27659-27667(2002) GeneRIF 3938 · Mapped (21)
demonstrate that GATA-5 and HNF-1alpha physically associate both in vivo and in vitro and that this interaction is necessary for cooperative activation of the lactase-phlorizin hydrolase promoter GeneRIF 3938

van Wering H.M., Moyer L., Grand R.J., Krasinski S.D.

Biochem. Biophys. Res. Commun. 299:587-593(2002) GeneRIF 3938 · Mapped (1)
Results suggest that repression of lactase-phlorizin hydrolase (LPH) gene expression is released in cells that synthesize Cdx-2 such as those in the intestinal epithelium. GeneRIF 3938

Kuokkanen M., Enattah N.S., Oksanen A., Savilahti E., Orpana A., Jarvela I.

Gut 52:647-652(2003) GeneRIF 3938 GAD 129472 · Mapped (1)
Associated with OTHER: adult-type hypolactasia; GAD 129472 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3938

Olds L.C., Sibley E.

Hum. Mol. Genet. 12:2333-2340(2003) GeneRIF 3938 · UniProtKB (1) · Mapped (1)
A lactase persistent variant enhances lactase promoter activity in vitro. GeneRIF 3938

Obermayer-Pietsch B.M., Bonelli C.M., Walter D.E., Kuhn R.J., Fahrleitner-Pammer A., Berghold A., Goessler W., Stepan V., Dobnig H., Leb G. et al.

J. Bone Miner. Res. 19:42-47(2004) GeneRIF 3938 GAD 129478 · Mapped (1)
Associated with METABOLIC: bone density; calcium; fractures, nonvertebral; milk intolerance; GAD 129478 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3938

Enattah N.S., Forsblom C., Rasinpera H., Tuomi T., Groop P.H., Jarvela I.

Eur J Clin Nutr 58:1319-1322(2004) GeneRIF 3938 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3938

Mulcare C.A., Weale M.E., Jones A.L., Connell B., Zeitlyn D., Tarekegn A., Swallow D.M., Bradman N., Thomas M.G.

Am. J. Hum. Genet. 74:1102-1110(2004) GeneRIF 3938 · Mapped (1)
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) GeneRIF 3938

Wang Z., Fang R., Olds L.C., Sibley E.

Am. J. Physiol. Gastrointest. Liver Physiol. 287:G555-61(2004) GeneRIF 3938 · Mapped (2)
Stable overexpression of pancreatic duodenal homeobox-1 results in repression of the endogenous human lactase-phlorizin hydrolase gene in differentiated Caco-2 cells GeneRIF 3938

van Wering H.M., Bosse T., Musters A., de Jong E., de Jong N., Hogen Esch C.E., Boudreau F., Swain G.P., Dowling L.N., Montgomery R.K. et al.

Am. J. Physiol. Gastrointest. Liver Physiol. 287:G899-909(2004) GeneRIF 3938 · Mapped (8)
GATA-4 is a key regulator of LPH gene expression that may function through an evolutionarily conserved mechanism involving cooperativity with an HNF-1alpha and/or a GATA-specific pathway independent of HNF-1alpha. GeneRIF 3938

Enattah N., Valimaki V.V., Valimaki M.J., Loyttyniemi E., Sahi T., Jarvela I.

Calcif. Tissue Int. 75:488-493(2004) GeneRIF 3938 · Mapped (1)
The adjustments for age height weight smoking alcohol consumption and physical exercise in the multiple regression analysis did not reveal any big relationships between the lactase genotypes and BMDs at lumbar femoral neck or total hip sites. GeneRIF 3938

Rasinpera H., Savilahti E., Enattah N.S., Kuokkanen M., Totterman N., Lindahl H., Jarvela I., Kolho K.L.

Gut 53:1571-1576(2004) GeneRIF 3938 · Mapped (1)
Observational study of genetic testing. (HuGE Navigator) GeneRIF 3938

Enattah N.S., Sulkava R., Halonen P., Kontula K., Jarvela I.

J Am Geriatr Soc 53:79-82(2005) GeneRIF 3938 GAD 129481 · Mapped (1)
Associated with METABOLIC: bone fractures; GAD 129481 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3938

Hogenauer C., Hammer H.F., Mellitzer K., Renner W., Krejs G.J., Toplak H.

Eur J Gastroenterol Hepatol 17:371-376(2005) GeneRIF 3938 · Mapped (1)
Observational study of genetic testing. (HuGE Navigator) GeneRIF 3938

Buning C., Genschel J., Jurga J., Fiedler T., Voderholzer W., Fiedler E.M., Worm M., Weltrich R., Lochs H., Schmidt H. et al.

Digestion 71:245-250(2005) GeneRIF 3938 · Mapped (1)
Observational study of genetic testing. (HuGE Navigator) GeneRIF 3938

Ridefelt P., Hakansson L.D.

Scand. J. Gastroenterol. 40:822-826(2005) GeneRIF 3938 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3938

Lewinsky R.H., Jensen T.G., Moller J., Stensballe A., Olsen J., Troelsen J.T.

Hum. Mol. Genet. 14:3945-3953(2005) GeneRIF 3938 · Mapped (1)
the binding of Oct-1 to the T-13 910 lactase variant directs increased lactase promoter activity and this might provide an explanation for the lactase persistence phenotype in the human population GeneRIF 3938

Bodlaj G., Stocher M., Hufnagl P., Hubmann R., Biesenbach G., Stekel H., Berg J.

Clin. Chem. 52:148-151(2006) GeneRIF 3938 · Mapped (1)
Observational study of genotype prevalence gene-disease association and genetic testing. (HuGE Navigator) GeneRIF 3938

Szilagyi A., Malolepszy P., Hamard E., Xue X., Hilzenrat N., Ponniah M., MacNamara E., Chong G.

Clin. Gastroenterol. Hepatol. 5:192-196(2007) GeneRIF 3938 · Mapped (1)
Observational study of genetic testing. (HuGE Navigator) GeneRIF 3938

Lehtimaki T., Hemminki J., Rontu R., Mikkila V., Rasanen L., Laaksonen M., Hutri-Kahonen N., Kahonen M., Viikari J., Raitakari O.

Pediatrics 118:1553-1559(2006) GeneRIF 3938 · Mapped (1)
lactase-phlorizin hydrolase C/C-13910 genotype was not associated with mean growth speed or final mean body height; however it contributed significantly to milk product consumption and dietary calcium intake from childhood into young adulthood GeneRIF 3938

Ingram C.J., Elamin M.F., Mulcare C.A., Weale M.E., Tarekegn A., Raga T.O., Bekele E., Elamin F.M., Thomas M.G., Bradman N. et al.

Hum. Genet. 120:779-788(2007) GeneRIF 3938 · Mapped (1)
cohort study of lactose digester and non-digester Sudanese volunteers shows there is no association of -13910*T or the A haplotype with lactase persistence; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3938

Lember M., Torniainen S., Kull M., Kallikorm R., Saadla P., Rajasalu T., Komu H., Jarvela I.

World J. Gastroenterol. 12:7329-7331(2006) GeneRIF 3938 · Mapped (1)
Milk consumption of lactose intolerant subjects is consistent with previously reported figures of adult-type hypolactasia in Estonia. GeneRIF 3938