Buervenich S., Sydow O., Carmine A., Zhang Z., Anvret M., Olson L.

Mov. Disord. 15:813-818(2000) GAD 115624 GeneRIF 127 · Mapped (1)
Associated with NEUROLOGICAL: Parkinson's disease; GAD 115624 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Guindalini C., Scivoletto S., Ferreira R.G., Breen G., Zilberman M., Peluso M.A., Zatz M.

Am J Psychiatry 162:1005-1007(2005) GAD 115626 GeneRIF 127 · Mapped (1)
Associated with CHEMDEPENDENCY: alcohol abuse; GAD 115626 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Luo X., Kranzler H.R., Zuo L., Lappalainen J., Yang B.Z., Gelernter J.

Neuropsychopharmacology 31:1085-1095(2006) GAD 115628 GeneRIF 127 · Mapped (1)
Associated with CHEMDEPENDENCY: alcohol dependence; drug dependence; GAD 115628 Observational study of gene-disease association. (HuGE Navigator); Seven single nucleotide polymorphisms spanning the ADH4 gene were genotyped in 561 subjects affected with alcohol dependence and/or drug dependence. GeneRIF 127

Tabakoff B., Saba L., Printz M., Flodman P., Hodgkinson C., Goldman D., Koob G., Richardson H.N., Kechris K., Bell R.L. et al.

BMC Biol. 7:70-70(2009) GAD 570160 GeneRIF 127 · Mapped (546)
Not Associated with CHEMDEPENDENCY: alcohol consumption; GAD 570160 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Rainero I., Rubino E., Gallone S., Fenoglio P., Negro E., De Martino P., Savi L., Pinessi L.

Headache 50:92-98(2010) GAD 570158 GeneRIF 127 · Mapped (1)
Associated with CHEMDEPENDENCY: alcohol; GAD 570158 Observational study of gene-disease association. (HuGE Navigator); Our data suggest that cluster headache is associated with the ADH4 gene or a linked locus. Additional studies are warranted to elucidate the role of this gene in the etiopathogenesis of the disease. GeneRIF 127

Ogurtsov P.P., Garmash I.V., Miandina G.I., Guschin A.E., Itkes A.V., Moiseev V.S.

Addict Biol 6:377-383(2001) GeneRIF 127 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Iida A., Saito S., Sekine A., Kondo K., Mishima C., Kitamura Y., Harigae S., Osawa S., Nakamura Y.

J. Hum. Genet. 47:74-76(2002) GeneRIF 127 · Mapped (1)
Thirteen new single nucleotide polymorphisms GeneRIF 127

Stromberg P., Svensson S., Hedberg J.J., Nordling E., Hoog J.O.

Cell. Mol. Life Sci. 59:552-559(2002) GeneRIF 127 · Mapped (1)
Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2 GeneRIF 127

Chou C.F., Lai C.L., Chang Y.C., Duester G., Yin S.J.

J. Biol. Chem. 277:25209-25216(2002) GeneRIF 127 · Mapped (1)
kinetic mechanisms for ADH4 functioning as retinol dehydrogenase GeneRIF 127

Galter D., Carmine A., Buervenich S., Duester G., Olson L.

Eur. J. Biochem. 270:1316-1326(2003) GeneRIF 127 · Mapped (8)
Results describe the expression patterns of alcohol dehydrogenases I III and IV in adult rat mouse and human tissues using radioactive oligonucleotide in situ hybridization. GeneRIF 127

Neumark Y.D., Friedlander Y., Durst R., Leitersdorf E., Jaffe D., Ramchandani V.A., O'Connor S., Carr L.G., Li T.K.

Alcohol. Clin. Exp. Res. 28:10-14(2004) GeneRIF 127 · Mapped (9)
The mean alcohol-elimination rate among ADH2*2 carriers is significantly higher than among ADH2*1 homozygotes in a male Jewish population. GeneRIF 127

Luo X., Kranzler H.R., Zuo L., Yang B.Z., Lappalainen J., Gelernter J.

Pharmacogenet. Genomics 15:755-768(2005) GeneRIF 127 GAD 115627 · Mapped (1)
Associated with CHEMDEPENDENCY: alcohol dependence; cocaine dependence; GAD 115627 the genotypes of six ADH4 markers were associated with alcohol dependence and all seven ADH4 markers were associated with drug dependence; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Luo X., Kranzler H.R., Zuo L., Wang S., Gelernter J.

Biol. Psychiatry 61:599-608(2007) GeneRIF 127 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator); that personality traits and substance dependence have a partially overlapping genetic basis. GeneRIF 127

Kuo P.H., Kalsi G., Prescott C.A., Hodgkinson C.A., Goldman D., van den Oord E.J., Alexander J., Jiang C., Sullivan P.F., Patterson D.G. et al.

Alcohol. Clin. Exp. Res. 32:785-795(2008) GeneRIF 127 · Mapped (25)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Luo X., Zuo L., Kranzler H.R., Wang S., Anton R.F., Gelernter J.

Behav Brain Funct 4:42-42(2008) GeneRIF 127 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Macgregor S., Lind P.A., Bucholz K.K., Hansell N.K., Madden P.A., Richter M.M., Montgomery G.W., Martin N.G., Heath A.C., Whitfield J.B.

Hum. Mol. Genet. 18:580-593(2009) GeneRIF 127 · Mapped (18)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Kimura Y., Nishimura F.T., Abe S., Fukunaga T., Tanii H., Saijoh K.

J Toxicol Sci 34:89-97(2009) GeneRIF 127 · Mapped (6)
Class II alcohol dehydogenase (ADH4) is considered to contribute to ethanol oxidation in the liver at high concentration; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Birley A.J., James M.R., Dickson P.A., Montgomery G.W., Heath A.C., Martin N.G., Whitfield J.B.

Hum. Mol. Genet. 18:1533-1542(2009) GeneRIF 127 · Mapped (12)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Saito A., Kawamoto M., Kamatani N.

J. Hum. Genet. 54:317-323(2009) GeneRIF 127 · Mapped (766)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Zuccolo L., Fitz-Simon N., Gray R., Ring S.M., Sayal K., Smith G.D., Lewis S.J.

Hum. Mol. Genet. 18:4457-4466(2009) GeneRIF 127 · Mapped (10)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Oze I., Matsuo K., Suzuki T., Kawase T., Watanabe M., Hiraki A., Ito H., Hosono S., Ozawa T., Hatooka S. et al.

Cancer Epidemiol. Biomarkers Prev. 18:3097-3102(2009) GeneRIF 127 · Mapped (16)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator); ADH4 gene polymorphisms are associated with upper aerodigestive tract cancers. GeneRIF 127

CPNDS Consortium
Ross C.J., Katzov-Eckert H., Dube M.P., Brooks B., Rassekh S.R., Barhdadi A., Feroz-Zada Y., Visscher H., Brown A.M., Rieder M.J. et al.

Nat. Genet. 41:1345-1349(2009) GeneRIF 127 · Mapped (250)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Pochareddy S., Edenberg H.J.

Gene 460:1-7(2010) GeneRIF 127 · Mapped (1)
In this study we have identified a distal upstream enhancer 4E of ADH4. In HepG2 human hepatoma cells 4E increased the activity of an ADH4 basal promoter by 50-fold. 4E was cell-specific. GeneRIF 127

Liu C.Y., Wu M.C., Chen F., Ter-Minassian M., Asomaning K., Zhai R., Wang Z., Su L., Heist R.S., Kulke M.H. et al.

Carcinogenesis 31:1259-1263(2010) GeneRIF 127 · Mapped (1,655)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 127

Preuss U.W., Ridinger M., Rujescu D., Samochowiec J., Fehr C., Wurst F.M., Koller G., Bondy B., Wodarz N., Debniak T. et al.

Addict Biol 16:323-333(2011) GeneRIF 127 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator); This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. GeneRIF 127