European Consortium on Rheumatoid Arthritis Families
Jacq L., Garnier S., Dieude P., Michou L., Pierlot C., Migliorini P., Balsa A., Westhovens R., Barrera P., Alves H. et al.

Arthritis Res. Ther. 9:R63-R63(2007) GAD 150346 GeneRIF 3685 · Mapped (5)
Associated with IMMUNE: rheumatoid arthritis; GAD 150346 Observational study of gene-disease association. (HuGE Navigator); The rs3738919-C allele of the ITGAV gene is associated with rheumatoid arthritis in the European Caucasian population suggesting ITGAV as a new minor susceptibility gene for rheumatoid arthritis. GeneRIF 3685

Deryugina E.I., Ratnikov B.I., Postnova T.I., Rozanov D.V., Strongin A.Y.

J. Biol. Chem. 277:9749-9756(2002) GeneRIF 3685 · Mapped (5)
Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin GeneRIF 3685

Chettab K., Zibara K., Belaiba S.R., McGregor J.L.

Thromb. Haemost. 87:141-148(2002) GeneRIF 3685 · Mapped (24)
Acute hyperglycaemia induces an up-regulation of seven major genes four of which were not previously reported in the literature. Northern blot analyses performed on these 4 genes confirm macroarrays results for alphav beta4 c-myc and MUC18. GeneRIF 3685

Sajid M., Stouffer G.A.

Thromb. Haemost. 87:187-193(2002) GeneRIF 3685 · Mapped (10)
Review. Alpha(v)beta3 integrins are involved in vascular repair processes. The challenge is to develop a therapeutic agent that will prove effective in reducing restenosis in humans following percutaneous coronary intervention (PCI). GeneRIF 3685

Ahmed N., Pansino F., Clyde R., Murthi P., Quinn M.A., Rice G.E., Agrez M.V., Mok S., Baker M.S.

Carcinogenesis 23:237-244(2002) GeneRIF 3685 · Mapped (5)
They analyzed the expression of these cell surface receptors in nine ovarian cancer cell lines and also in the primary human ovarian surface epithelial cell line (HOSE). GeneRIF 3685

Angelucci A., Festuccia C., D'Andrea G., Teti A., Bologna M.

Biol. Chem. 383:229-234(2002) GeneRIF 3685 · Mapped (20)
Chemotaxis and chemoinvasion analyses revealed a dose-dependent increase in prostate cancer cell movement induced by osteopontin and a strict dependence of cell invasion on alphavbeta3 integrin function. GeneRIF 3685

Pilch J., Habermann R., Felding-Habermann B.

J. Biol. Chem. 277:21930-21938(2002) GeneRIF 3685 · Mapped (10)
Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions (Integrin alpha-v beta-3) GeneRIF 3685

Rezaee M., Penta K., Quertermous T.

Am. J. Physiol. Heart Circ. Physiol. 282:H1924-32(2002) GeneRIF 3685 · Mapped (16)
Del1 mediates vascular smooth muscle cell adhesion migration and proliferation through interaction with integrin alpha(v)beta(3). GeneRIF 3685

Dardik R., Shenkman B., Tamarin I., Eskaraev R., Harsfalvi J., Varon D., Inbal A.

Thromb. Res. 105:317-323(2002) GeneRIF 3685 · Mapped (16)
Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins. GeneRIF 3685

Yamani M.H., Yang J., Masri C.S., Ratliff N.B., Bond M., Starling R.C., McCarthy P., Plow E., Young J.B.

Am. J. Transplant. 2:129-133(2002) GeneRIF 3685 · Mapped (12)
Acute cellular rejection following human heart transplantation is associated with increased expression GeneRIF 3685

Nejjari M., Hafdi Z., Gouysse G., Fiorentino M., Beatrix O., Dumortier J., Pourreyron C., Barozzi C., D'errico A., Grigioni W.F. et al.

Hepatology 36:418-426(2002) GeneRIF 3685 · Mapped (5)
existence of an alpha V integrin/vitronectin connection in hepatocellular carcinoma and suggest that this connection may be an adverse prognostic factor. GeneRIF 3685

Ria R., Vacca A., Ribatti D., Di Raimondo F., Merchionne F., Dammacco F.

Haematologica 87:836-845(2002) GeneRIF 3685 · Mapped (10)
Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma. GeneRIF 3685

Moretti R.M., Montagnani Marelli M., Motta M., Limonta P.

Oncol. Rep. 9:1139-1143(2002) GeneRIF 3685 · Mapped (20)
integrin alphaVbeta3 expression is reduced when ROR alpha is activated in prostate cancer cells GeneRIF 3685

Felding-Habermann B., Fransvea E., O'Toole T.E., Manzuk L., Faha B., Hensler M.

Clin. Exp. Metastasis 19:427-436(2002) GeneRIF 3685 · Mapped (10)
Integrin alphavbeta3. Expression of integrin alpha v beta 3 promotes the metastatic phenotype in human melanoma by supporting specific adhesive invasive and migratory properties of the tumor cells GeneRIF 3685

Weyts F.A., Li Y.S., van Leeuwen J., Weinans H., Chien S.

J. Cell. Biochem. 87:85-92(2002) GeneRIF 3685 · Mapped (10)
alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts GeneRIF 3685

Paulhe F., Perret B., Chap H., Iberg N., Morand O., Racaud-Sultan C.

Biochem. Biophys. Res. Commun. 297:261-266(2002) GeneRIF 3685 · Mapped (15)
phosphoinositide 3-kinase C2alpha was found to be differentially regulated by alpha(v)beta(3) engagement GeneRIF 3685

Dormond O., Bezzi M., Mariotti A., Ruegg C.

J. Biol. Chem. 277:45838-45846(2002) GeneRIF 3685 · Mapped (10)
promotion of integrin alpha Vbeta 3-dependent endothelial cell adhesion by PGE2 GeneRIF 3685

Kim J.E., Jeong H.W., Nam J.O., Lee B.H., Choi J.Y., Park R.W., Park J.Y., Kim I.S.

J. Biol. Chem. 277:46159-46165(2002) GeneRIF 3685 · Mapped (8)
identification of a new alphavbeta5 integrin-interacting motif that is highly conserved in the fas-1 domains of many proteins suggesting that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins GeneRIF 3685

Jarad G., Wang B., Khan S., DeVore J., Miao H., Wu K., Nishimura S.L., Wible B.A., Konieczkowski M., Sedor J.R. et al.

J. Biol. Chem. 277:47826-47833(2002) GeneRIF 3685 · Mapped (9)
induced alpha(v)beta(8) integrin expression mediated Fas-stimulated migration GeneRIF 3685

Xiong Y.M., Haas T.A., Zhang L.

J. Biol. Chem. 277:46639-46644(2002) GeneRIF 3685 · Mapped (12)
identification of functional segments within the beta2I-domain GeneRIF 3685

Ludbrook S.B., Barry S.T., Delves C.J., Horgan C.M.

Biochem. J. 369:311-318(2003) GeneRIF 3685 · Mapped (10)
Data show clearly that integrin alpha(v)beta(3) interacts with the latency-associated peptide (LAPbeta1 and 3) RGD motif. GeneRIF 3685

Leu S.J., Lam S.C., Lau L.F.

J. Biol. Chem. 277:46248-46255(2002) GeneRIF 3685 · Mapped (19)
role in mediating pro-angiogenic activity of CYR61 GeneRIF 3685

Graf R., Freyberg M., Kaiser D., Friedl P.

Apoptosis 7:493-498(2002) GeneRIF 3685 · Mapped (10)
An autocrine loop of the integrin alpha(V)beta(3)/CD47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis. GeneRIF 3685

Khorram O., Lessey B.A.

Fertil. Steril. 78:860-864(2002) GeneRIF 3685 · Mapped (17)
in patients with endometriosis a significant negative correlation was observed between luminal expression of eNOS and alpha(v)beta(3) integrin and between glandular expression of eNOS and luminal expression of alpha(v)beta(3) integrin GeneRIF 3685

Tsopanoglou N.E., Andriopoulou P., Maragoudakis M.E.

Am. J. Physiol., Cell Physiol. 283:C1501-10(2002) GeneRIF 3685 · Mapped (10)
thrombin interacts with alphavbeta3 as demonstrated by direct binding of alphavbeta3 protein to immobilized thrombin. GeneRIF 3685