Kazmirski S.L., Isaacson R.L., An C., Buckle A., Johnson C.M., Daggett V., Fersht A.R.

Nat. Struct. Biol. 9:112-116(2002) GeneRIF 2934 PDB 1KCQ · Mapped (10)
crystal structure: loss of a metal-binding site leads to familial amyloidosis-Finnish type GeneRIF 2934

Fujita H.

Seikagaku 74:135-139(2002) GeneRIF 2934 · Mapped (10)
functions as a regulator of cell growth and apoptosis GeneRIF 2934

Dong Y., Asch H.L., Ying A., Asch B.B.

Exp. Cell Res. 276:328-336(2002) GeneRIF 2934 · Mapped (10)
ATF-1 DNA-binding activity was abundant in breast cancer cells and correlated inversely with gelsolin mRNA levels. This suggests a role for ATF-1 in gelsolin promoter silencing in contrast to its transactivating effect on various other promoters. GeneRIF 2934

Xian W., Janmey P.A.

J. Mol. Biol. 322:755-771(2002) GeneRIF 2934 · Mapped (15)
explores the structure-function relationship of the gelsolin-PPI interaction GeneRIF 2934

Choe H., Burtnick L.D., Mejillano M., Yin H.L., Robinson R.C., Choe S.

J. Mol. Biol. 324:691-702(2002) GeneRIF 2934 PDB 1H1V · Mapped (11)
Calcium activation of gelsolin: X-Ray crystallography model of the G4-G6/actin complex. GeneRIF 2934

Sagawa N., Fujita H., Banno Y., Nozawa Y., Katoh H., Kuzumaki N.

Br. J. Cancer 88:606-612(2003) GeneRIF 2934 · Mapped (10)
Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line PC10. GeneRIF 2934

Haga K.

Hokkaido Igaku Zasshi 78:29-37(2003) GeneRIF 2934 · Mapped (10)
Its reduced expression in bladder cancer is regulated by DNA methylation histone acetylation and chromatin remodeling. GeneRIF 2934

Kiselar J.G., Janmey P.A., Almo S.C., Chance M.R.

Proc. Natl. Acad. Sci. U.S.A. 100:3942-3947(2003) GeneRIF 2934 · Mapped (10)
A visualization of the Ca2+-dependent activation of this protein by using synchrotron footprinting. GeneRIF 2934

Lagarrigue E., Maciver S.K., Fattoum A., Benyamin Y., Roustan C.

Eur. J. Biochem. 270:2236-2243(2003) GeneRIF 2934 · Mapped (10)
analysis of domain-binding and calcium-binding sites in gelsolin GeneRIF 2934

Vartanian A.A.

Ital. J. Biochem. 52:9-16(2003) GeneRIF 2934 · Mapped (14)
Gelsolin and plasminogen activator inhibitor-1 have roles as Ap3A-binding proteins GeneRIF 2934

Kiselar J.G., Janmey P.A., Almo S.C., Chance M.R.

Mol. Cell Proteomics 2:1120-1132(2003) GeneRIF 2934 · Mapped (10)
conformational dynamics of ligand-induced structural changes GeneRIF 2934

Narayan K., Chumnarnsilpa S., Choe H., Irobi E., Urosev D., Lindberg U., Schutt C.E., Burtnick L.D., Robinson R.C.

FEBS Lett. 552:82-85(2003) GeneRIF 2934 PDB 1P8X · Mapped (10)
structure of the isolated C-terminal half of gelsolin (G4-G6) at 2.0 A resolution in the presence of Ca(2+) ions GeneRIF 2934

Irobi E., Burtnick L.D., Urosev D., Narayan K., Robinson R.C.

FEBS Lett. 552:86-90(2003) GeneRIF 2934 PDB 1P8Z · Mapped (11)
2.6 A resolution crystal structure of a complex formed between G-actin and gelsolin fragment Met25-Gln160 GeneRIF 2934

Huff M.E., Page L.J., Balch W.E., Kelly J.W.

J. Mol. Biol. 334:119-127(2003) GeneRIF 2934 · Mapped (11)
Data suggest that mutations that diminish domain 2 Ca(2+) binding allow furin access to an otherwise protected cleavage site initiating the proteolytic cascade that leads to gelsolin amyloidogenesis and familial amyloidosis of Finnish type. GeneRIF 2934

Ahn J.S., Jang I.S., Kim D.I., Cho K.A., Park Y.H., Kim K., Kwak C.S., Chul Park S.

Biochem. Biophys. Res. Commun. 312:1335-1341(2003) GeneRIF 2934 · Mapped (12)
the observed ubiquitous increase of gelsolin in the senescent states of cells and tissues and the increased sensitivity to apoptosis-induction by gelsolin down-regulation suggests that it would be partly responsible for age-related apoptosis resistance GeneRIF 2934

Ahn J.S., Jang I.S., Rhim J.H., Kim K., Yeo E.J., Park S.C.

Ann. N. Y. Acad. Sci. 1010:493-495(2003) GeneRIF 2934 · Mapped (10)
Gelsolin is involved in the apoptotic resistance in senescent human diploid fibroblasts. GeneRIF 2934

Klampfer L., Huang J., Sasazuki T., Shirasawa S., Augenlicht L.

J. Biol. Chem. 279:36680-36688(2004) GeneRIF 2934 · Mapped (17)
gelsolin protects cells from butyrate-induced apoptosis GeneRIF 2934

Burtnick L.D., Urosev D., Irobi E., Narayan K., Robinson R.C.

EMBO J. 23:2713-2722(2004) GeneRIF 2934 · Mapped (12)
The structure of the N-terminal half of gelsolin bound to actin was studied as well as its roles in severing apoptosis and familial amyloidosis. GeneRIF 2934

Boccellino M., Giuberti G., Quagliuolo L., Marra M., D'Alessandro A.M., Fujita H., Giovane A., Abbruzzese A., Caraglia M.

J. Cell. Physiol. 201:71-83(2004) GeneRIF 2934 · Mapped (10)
IFNalpha can induce morphological cell changes that are peculiar of apoptosis onset through the caspase-3-mediated cleavage of gelsolin. GeneRIF 2934

Alekperova G.A., Orudzhev A.G., Javadov S.A.

Biochemistry Mosc. 69:748-753(2004) GeneRIF 2934 · Mapped (42)
Analysis of major platelet membrane proteins revealed significant increase in gelsolin from patients with homozygous and heterozygous forms of beta-thalassemia. GeneRIF 2934

Fock U., Jockusch B.M., Schubert W.D., Hinssen H.

Biochem. J. 385:659-665(2005) GeneRIF 2934 · Mapped (10)
model of the N-terminal extension on the surface of the gelsolin molecule which was unknown previously GeneRIF 2934

Silacci P., Mazzolai L., Gauci C., Stergiopulos N., Yin H.L., Hayoz D.

Cell. Mol. Life Sci. 61:2614-2623(2004) GeneRIF 2934 · Mapped (10)
Gelsolin has a role as a regulator of cellular functions [review] GeneRIF 2934

Mere J., Chahinian A., Maciver S.K., Fattoum A., Bettache N., Benyamin Y., Roustan C.

Biochem. J. 386:47-56(2005) GeneRIF 2934 · Mapped (10)
Gelsolin is partly buried in the lipid bilayer at low pH. The linker regionbetween G3 and G4 is involved in this interaction. Vesicle-bound gelsolin can bind to actin filaments presumably through barbed end capping. GeneRIF 2934

Liepina I., Janmey P., Czaplewski C., Liwo A.

Biopolymers 76:543-548(2004) GeneRIF 2934 · Mapped (10)
features of gelsolin amyloidogenic fragments comprised of residues 173-243 and residues 173-202 were investigated GeneRIF 2934

Lader A.S., Lee J.J., Cicchetti G., Kwiatkowski D.J.

Exp. Cell Res. 307:153-163(2005) GeneRIF 2934 · Mapped (10)
Mechanisms of GSN dependent and independent EGF stimulated cell motility were studied in an epithelial cell line. GeneRIF 2934