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1 - 25 of 1,330 results for uniprot:P05067 in Computationally mapped citations

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Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia.

Arango D., Cruts M., Torres O., Backhovens H., Serrano M.L., Villareal E., Montanes P., Matallana D., Cano C., Van Broeckhoven C. et al.

Am. J. Med. Genet. 103:138-143(2001) GAD 117466 GeneRIF 351 · Mapped (17)
Not Associated with NEUROLOGICAL: Alzheimer's Disease; GAD 117466 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 351

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

Harris S.E., Fox H., Wright A.F., Hayward C., Starr J.M., Whalley L.J., Deary I.J.

BMC Genet. 8:43-43(2007) GAD 144556 GeneRIF 351 GAD 596670 · Mapped (565)
Associated with NEUROLOGICAL: cognitive trait; GAD 596670 Associated with PSYCH: cognitive function; GAD 144556 Observational study of gene-disease association. (HuGE Navigator); This study suggests a possible role for APP in normal cognitive ageing in addition to its role in Alzheimer's disease GeneRIF 351

Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.

Starr J.M., Shiels P.G., Harris S.E., Pattie A., Pearce M.S., Relton C.L., Deary I.J.

Mech. Ageing Dev. 129:745-751(2008) GAD 586435 GeneRIF 351 · Mapped (571)
Not Associated with AGING: Aging/ Telomere Length; GAD 586435 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 351

RFLP analysis for APP 717 mutations associated with Alzheimer's disease.

Zeldenrust S.R., Murrell J., Farlow M., Ghetti B., Roses A.D., Benson M.D.

J. Med. Genet. 30:476-478(1993) GAD 117464 · Mapped (10)
Associated with NEUROLOGICAL: Alzheimer's Disease; GAD 117464

Further evidence for an association between a mutation in the APP gene and Lewy body formation.

Halliday G., Brooks W., Arthur H., Creasey H., Broe G.A.

Neurosci. Lett. 227:49-52(1997) GAD 117463 · Mapped (10)
Associated with NEUROLOGICAL: Lewy Body Formation; GAD 117463

Polymorphic tetranucleotide repeat site within intron 7 of the beta-amyloid precursor protein gene and its lack of association with Alzheimer's disease.

Li L., Perry R., Wu J., Pham D., Ohman T., Harrell L.E., Go R.C., Fukuchi K.

Hum. Genet. 103:86-89(1998) GAD 117462 · Mapped (10)
Not Associated with NEUROLOGICAL: Alzheimer's Disease; GAD 117462

The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons.

Caswell M.D., Mok S.S., Henry A., Cappai R., Klug G., Beyreuther K., Masters C.L., Small D.H.

Eur. J. Biochem. 266:509-516(1999) GeneRIF 351 · Mapped (10)
Kunitz protease inhibitor (KPI) domain forms of APP regulate extracellular cleavage of secreted APP by inhibiting the activity of a secreted APP-degrading protease GeneRIF 351

Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.

Milton N.G.

Biochem. J. 344:293-296(1999) GeneRIF 351 · Mapped (10)
Alzheimer's Amyloid-beta peptide contains catalase binding site and inhibits anti-oxidant activity GeneRIF 351

The amyloid precursor protein locus and very-late-onset Alzheimer disease.

Olson J.M., Goddard K.A., Dudek D.M.

Am. J. Hum. Genet. 69:895-899(2001) GeneRIF 351 · Mapped (10)
Mutations in APP may predispose to very-late-onset Alzheimer disease. GeneRIF 351

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.

Kirkitadze M.D., Condron M.M., Teplow D.B.

J. Mol. Biol. 312:1103-1119(2001) GeneRIF 351 · Mapped (10)
helix-containing intermediates in amyloid beta-protein fibrillogenesis GeneRIF 351

Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase.

Milton N.G.

Neuroreport 12:3839-3844(2001) GeneRIF 351 · Mapped (10)
Serine phosphorylation site within the Alzheimer's Amyloid-beta sequence GeneRIF 351

Structure determination of micelle-like intermediates in amyloid beta -protein fibril assembly by using small angle neutron scattering.

Yong W., Lomakin A., Kirkitadze M.D., Teplow D.B., Chen S.H., Benedek G.B.

Proc. Natl. Acad. Sci. U.S.A. 99:150-154(2002) GeneRIF 351 · Mapped (10)
Here the technique of small angle neutron scattering has been used to determine the structure of these Abeta micelles GeneRIF 351

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).

Edbauer D., Willem M., Lammich S., Steiner H., Haass C.

J. Biol. Chem. 277:13389-13393(2002) GeneRIF 351 · Mapped (24)
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). GeneRIF 351

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis.

Greenfield J.P., Leung L.W., Cai D., Kaasik K., Gross R.S., Rodriguez-Boulan E., Greengard P., Xu H.

J. Biol. Chem. 277:12128-12136(2002) GeneRIF 351 · Mapped (19)
Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis GeneRIF 351

CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease.

Blennow K., Vanmechelen E., Hampel H.

Mol. Neurobiol. 24:87-97(2001) GeneRIF 351 · Mapped (16)
a biomarker for Alzheimer disease GeneRIF 351

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome.

Busciglio J., Pelsman A., Wong C., Pigino G., Yuan M., Mori H., Yankner B.A.

Neuron 33:677-688(2002) GeneRIF 351 · Mapped (10)
mitochondrial dysfunction in Down's syndrome may lead to intracellular deposition of Abeta42 reduced levels of AbetaPPs and a chronic state of increased neuronal vulnerability. GeneRIF 351

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection.

Wei W., Wang X., Kusiak J.W.

J. Biol. Chem. 277:17649-17656(2002) GeneRIF 351 · Mapped (10)
early signaling mechanisms involved in Abeta toxicity using the SH-SY5Y neuroblastoma cell line (amyloid beta protein) GeneRIF 351

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.

Ji Z.S., Miranda R.D., Newhouse Y.M., Weisgraber K.H., Huang Y., Mahley R.W.

J. Biol. Chem. 277:21821-21828(2002) GeneRIF 351 · Mapped (33)
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells GeneRIF 351

Oxidation of methionine 35 attenuates formation of amyloid beta -peptide 1-40 oligomers.

Palmblad M., Westlind-Danielsson A., Bergquist J.

J. Biol. Chem. 277:19506-19510(2002) GeneRIF 351 · Mapped (10)
Oxidation of methionine 35 attenuates formation of amyloid beta -peptide 1-40 oligomers GeneRIF 351

Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.

Dineley K.T., Xia X., Bui D., Sweatt J.D., Zheng H.

J. Biol. Chem. 277:22768-22780(2002) GeneRIF 351 · Mapped (15)
Accelerated plaque accumulation associative learning deficits and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins GeneRIF 351

[Pathological implications of GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease].

Yanagisawa K.

Tanpakushitsu Kakusan Koso 47:344-350(2002) GeneRIF 351 · Mapped (10)
binds to G(M1)ganglioside and promotes the soluble amyloid beta protein polymerization GeneRIF 351

[Interactions between amyloid beta--protein and gangliosides].

Matsuzaki K.

Tanpakushitsu Kakusan Koso 47:351-356(2002) GeneRIF 351 · Mapped (10)
forms a seed of amyloid beta protein aggregation via binding to G(M1)ganglioside GeneRIF 351

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., Selkoe D.J.

Nature 416:535-539(2002) GeneRIF 351 · Mapped (10)
natural oligomers of human Abeta are secreted and cerebral microinjection of cell medium containing these oligomers and abundant Abeta monomers but no amyloid fibrils markedly inhibited hippocampal long-term potentiation in rats (amyloid beta protein). GeneRIF 351

The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity.

Milton N.G.

Neurosci. Lett. 322:131-133(2002) GeneRIF 351 · Mapped (10)
Activation of Cyclin-Dependent-Kinase-1 by Alzheimer's Amyloid-beta peptide GeneRIF 351

Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.

Ho C.S., Marinescu V., Steinhilb M.L., Gaut J.R., Turner R.S., Stuenkel E.L.

J. Biol. Chem. 277:27021-27028(2002) GeneRIF 351 · Mapped (17)
Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion. GeneRIF 351

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