Sakasegawa Y., Kishida H., Sakurai M., Asada T., Kinoshita T., Goto Y., Kimura H., Kuroiwa Y., Hachiya N.S., Kaneko K.

Neurosci. Lett. 353:49-52(2003) GAD 132061 GeneRIF 4914 · Mapped (2)
Not Associated with NEUROLOGICAL: Alzheimer's Disease; GAD 132061 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 4914

Landa I., Ruiz-Llorente S., Montero-Conde C., Inglada-Perez L., Schiavi F., Leskela S., Pita G., Milne R., Maravall J., Ramos I. et al.

PLoS Genet. 5:e1000637-e1000637(2009) GAD 593632 GeneRIF 4914 · Mapped (480)
Not Associated with CANCER: thyroid cancer; GAD 593632 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 4914

Lipska B.S., Drozynska E., Scaruffi P., Tonini G.P., Izycka-Swieszewska E., Zietkiewicz S., Balcerska A., Perek D., Chybicka A., Biernat W. et al.

BMC Cancer 9:436-436(2009) GAD 593631 GeneRIF 4914 · Mapped (2)
Associated with CANCER: Neuroblastoma; GAD 593631 NTRK1 c.1810C>T polymorphism appears to be a new independent prognostic factor of poor outcome in neuroblastoma; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 4914

Indo Y., Mardy S., Miura Y., Moosa A., Ismail E.A., Toscano E., Andria G., Pavone V., Brown D.L., Brooks A. et al.

Hum. Mutat. 18:308-318(2001) GeneRIF 4914 · Mapped (7)
congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene a putative uniparental disomy and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency GeneRIF 4914

Davidson B., Lazarovici P., Ezersky A., Nesland J.M., Berner A., Risberg B., Trope C.G., Kristensen G.B., Goscinski M., van de Putte G. et al.

Clin. Cancer Res. 7:3457-3464(2001) GeneRIF 4914 · Mapped (2)
TrkA is expressed in pleural and peritoneal effusions and in advanced-stage ovarian carcinoma. GeneRIF 4914

Kim G.J., Kim C.J., Cho S.Y., Chung I.P., Park S.H., Lee M.J., Chi J.G.

Lab. Invest. 82:221-229(2002) GeneRIF 4914 · Mapped (2)
biologic effects of trkA neurotrophin receptor activation by nerve growth factor in a newly established Askin tumor cell line GeneRIF 4914

Jiang H., Movsesyan V., Liu X.W., Katagiri Y., Monshipoyri M., Lazarovici P.

J. Mol. Neurosci. 17:293-302(2001) GeneRIF 4914 · Mapped (2)
Cys436 of the trkA is responsible for the rapid transfer of the transmembrane occupancy signal to the SHC adaptor protein for activation of the Ras-Erk pathway and DNA synthesis. GeneRIF 4914

Indo Y.

Clin. Auton. Res. 12 Suppl 1:I20-32(2002) GeneRIF 4914 · Mapped (2)
genetics of hereditary sensory and autonomic neuropathy type IV: clinical biological and molecular aspects of mutations (REVIEW) GeneRIF 4914

Tarr P.E., Contursi C., Roncarati R., Noviello C., Ghersi E., Scheinfeld M.H., Zambrano N., Russo T., D'Adamio L.

Biochem. Biophys. Res. Commun. 295:324-329(2002) GeneRIF 4914 · Mapped (2)
role in tyrosine phosphorylation and processing of beta-APP GeneRIF 4914

Yan C., Liang Y., Nylander K.D., Schor N.F.

Cancer Res. 62:4867-4875(2002) GeneRIF 4914 · Mapped (2)
TrkA as a life and death receptor: receptor dose as a mediator of function. GeneRIF 4914

Toscano E., Simonati A., Indo Y., Andria G.

Ann. Neurol. 52:224-227(2002) GeneRIF 4914 · Mapped (2)
No mutation in the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with hereditary sensory and autonomic neuropathy type V. GeneRIF 4914

Nakamura T., Komiya M., Sone K., Hirose E., Gotoh N., Morii H., Ohta Y., Mori N.

Mol. Cell. Biol. 22:8721-8734(2002) GeneRIF 4914 · UniProtKB (1) · Mapped (6)
These results suggest that Grit a novel TrkA-interacting protein regulates neurite outgrowth by modulating the Rho family of small GTPases. GeneRIF 4914

Ruiz-Ederra J., Hitchcock P.F., Vecino E.

Neurosci. Lett. 337:127-130(2003) GeneRIF 4914 · Mapped (2)
Most of the GFAP-positive cells express TrkA whereas a rare novel subpopulation of astrocytes was found to be devoid of TrkA. Those results support the idea that astrocytes play an important neurotrophic role in the retina. GeneRIF 4914

Woo C.W., Lucarelli E., Thiele C.J.

Oncogene 23:1522-1530(2004) GeneRIF 4914 · Mapped (2)
Nerve growth factor decreases N-myc levels in TRKA-infected neuroblastoma cells and decreases cell proliferation via a MAPK path. GeneRIF 4914

Tsuruda A., Suzuki S., Maekawa T., Oka S.

FEBS Lett. 560:215-220(2004) GeneRIF 4914 · Mapped (2)
Constitutively activated Scr facilitates NGF-induced phosphorylation of TRKA. GeneRIF 4914

Guo Y.C., Liao K.K., Soong B.W., Tsai C.P., Niu D.M., Lee H.Y., Lin K.P.

Eur. Neurol. 51:206-214(2004) GeneRIF 4914 · Mapped (2)
CIPA patients had a branch site mutation in intron 7 (IVS7-33 T-->A) of the NTRK1 gene and a marked reduction of small myelinated and unmyelinated fibers and a relatively increased axon size. This is the first CIPA family encountered in Taiwan GeneRIF 4914

Frattini M., Ferrario C., Bressan P., Balestra D., De Cecco L., Mondellini P., Bongarzone I., Collini P., Gariboldi M., Pilotti S. et al.

Oncogene 23:7436-7440(2004) GeneRIF 4914 · Mapped (5)
genes are rearranged in papillary thyroid cancer. GeneRIF 4914

Florenes V.A., Maelandsmo G.M., Holm R., Reich R., Lazarovici P., Davidson B.

Am. J. Clin. Pathol. 122:412-420(2004) GeneRIF 4914 · Mapped (2)
a role for TrkA activation in a subset of melanomas as a predictor of an aggressive phenotype and poor outcome GeneRIF 4914

Tokusashi Y., Asai K., Tamakawa S., Yamamoto M., Yoshie M., Yaginuma Y., Miyokawa N., Aoki T., Kino S., Kasai S. et al.

Int. J. Cancer 114:39-45(2005) GeneRIF 4914 · Mapped (5)
expression of NGF and its receptors TrkA and p75NTR in hepatocellular carcinomas (HCC); NGF and its receptors are thought to have a role in cellular interactions involving HCC cells hepatic stellate cells arterial cells and nerve cells in HCC tissues GeneRIF 4914

Schulte J.H., Schramm A., Klein-Hitpass L., Klenk M., Wessels H., Hauffa B.P., Eils J., Eils R., Brodeur G.M., Schweigerer L. et al.

Oncogene 24:165-177(2005) GeneRIF 4914 · Mapped (7)
upregulation of proapoptotic genes and angiogenesis inhibitors GeneRIF 4914

Hamano T., Mutoh T., Tabira T., Araki W., Kuriyama M., Mihara T., Yano S., Yamamoto H.

Brain Res. Mol. Brain Res. 137:70-76(2005) GeneRIF 4914 · Mapped (2)
These results strongly indicate that the expression level of PS1 protein has a cross talk with the Trk-dependent neuroprotective intracellular signaling pathway. GeneRIF 4914

Lavoie J.F., Lesauteur L., Kohn J., Wong J., Furtoss O., Thiele C.J., Miller F.D., Kaplan D.R.

J. Biol. Chem. 280:29199-29207(2005) GeneRIF 4914 · Mapped (34)
TrkA induces apoptosis of neuroblastoma cells through a p53-dependent mechanism GeneRIF 4914

Freund-Michel V., Bertrand C., Frossard N.

Cell. Signal. 18:621-627(2006) GeneRIF 4914 · Mapped (2)
Data show that nerve growth factor activation of the TrkA receptor involves two distinct signalling pathways and that both are necessary to induce airway smooth muscle cell proliferation. GeneRIF 4914

Barone R., Lempereur L., Anastasi M., Parano E., Pavone P.

Neuropediatrics 36:270-273(2005) GeneRIF 4914 · Mapped (2)
Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive disorder caused by mutations in the neurotrophic tyrosine receptor kinase 1 (NTRK1) gene which encodes the receptor for nerve growth factor (NGF). GeneRIF 4914

Arevalo J.C., Pereira D.B., Yano H., Teng K.K., Chao M.V.

J. Biol. Chem. 281:1001-1007(2006) GeneRIF 4914 · Mapped (2)
Trk receptor signaling involves an inducible switch mechanism through an unconventional substrate that distinguishes neurotrophin action from other growth factor receptors GeneRIF 4914