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No association with germline T cell receptor beta-chain gene alleles or haplotypes in Swedish patients with multiple sclerosis.

Hillert J., Leng C., Olerup O.

J. Neuroimmunol. 32:141-147(1991) GAD 141847 · Mapped (1)
Not Associated with IMMUNE: multiple sclerosis; GAD 141847

Anti-Ro(SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients.

Frank M.B., McArthur R., Harley J.B., Fujisaku A.

J. Clin. Invest. 85:33-39(1990) GAD 141843 · Mapped (1)
Associated with IMMUNE: Lupus; GAD 141843

T cell receptor beta chain polymorphisms are associated with cystic fibrosis.

McMillan S.A., Hill A.J., Graham C.A., Nevin N.C., Fay A.C.

J. Med. Genet. 26:431-433(1989) GAD 141848 · Mapped (1)
Associated with OTHER: cystic fibrosis.; GAD 141848

A T cell receptor beta chain variable region polymorphism associated with radiographic progression in rheumatoid arthritis.

de Vries N., Prinsen C.F., Mensink E.B., van Riel P.L., van't Hof M.A., van de Putte L.B.

Ann. Rheum. Dis. 52:327-331(1993) GAD 141844 · Mapped (1)
Associated with IMMUNE: rheumatoid arthritis; GAD 141844

Association study of proposed candidate genes/regions in a population of Spanish asthmatics.

Soriano J.B., de Cid R., Estivill X., Anto J.M., Sunyer J., Otero D., Roca J., Rodriguez-Roisin R., Morell F., Rodrigo M.J. et al.

Eur. J. Epidemiol. 16:745-750(2000) GeneRIF 6957 · Mapped (25)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6957

TCRBV3S1 and TCRBV18 gene segment polymorphisms in Brazilian Caucasoid and Black populations.

Dresch C., Nardi N.B., Chies J.A.

Eur. J. Immunogenet. 29:11-15(2002) GeneRIF 6957 · Mapped (3)
Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 6957

Unique TCR beta-subunit variable gene haplotypes in Africans.

Donaldson I.J., Shefta J., Lawson C.A., Bushnell J.R., Morgan A.W., Isaacs J.D., Carpenter D., Shaw M.A., Rooth I., Quinnell R.J. et al.

Immunogenetics 53:884-893(2002) GeneRIF 6957 · Mapped (1)
Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 6957

Malaria is not responsible for the selection of TCR beta-subunit variable gene haplotypes in The Gambia.

Donaldson I.J., Shefta J., Hill A.V., Boylston A.W.

Immunogenetics 53:894-899(2002) GeneRIF 6957 GAD 141854 · Mapped (1)
Not Associated with INFECTION: malaria; Case children suffering from severe malaria:Gambia;Control unaffected adult controls GAD 141854 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6957

Human T cell receptor-mediated recognition of HLA-E.

Garcia P., Llano M., de Heredia A.B., Willberg C.B., Caparros E., Aparicio P., Braud V.M., Lopez-Botet M.

Eur. J. Immunol. 32:936-944(2002) GeneRIF 6957 · Mapped (41)
Human T cells potentially recognize through the alpha beta TCR HLA-E molecules that bind to class I- and virus-derived peptides. GeneRIF 6957

Regional variation of the alphabeta T cell repertoire in the colon of healthy individuals and patients with Crohn's disease.

May E., Lambert C., Holtmeier W., Hennemann A., Zeitz M., Duchmann R.

Hum. Immunol. 63:467-480(2002) GeneRIF 6957 · Mapped (19)
variation of the beta T cell repertoire in the colon of healthy individuals and patients with Crohn's disease. GeneRIF 6957

Conserved CDR 3 region of T cell receptor BV gene in lymphocytes from bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis.

Shimizudani N., Murata H., Keino H., Kojo S., Nakamura H., Morishima Y., Sakamoto T., Ohtsuka M., Sekisawa K., Sumida M. et al.

Clin. Exp. Immunol. 129:140-149(2002) GeneRIF 6957 · Mapped (1)
Junctional sequence analysis showed the presence of conserved amino acid motifs (ETGRSG LAxG QGQ GxQP GRxG VAR PGT GTI GGT TGR LxLxQ SGQ) in the TCR-CDR 3 region of BAL lymphocytes in patients with IPF. Only VTTG & GGE were found in controls. GeneRIF 6957

Analysis of the T-cell receptor beta-chain variable-region (Vbeta) repertoire in chronic human Chagas' disease.

Fernandez-Mestre M.T., Jaraquemada D., Bruno R.E., Caro J., Layrisse Z.

Tissue Antigens 60:10-15(2002) GeneRIF 6957 · Mapped (1)
We found a significant increase of the Vbeta7 family in arrhythmic patients who were DRB1*01 DQB1*0501 DPB1*0401 a marker associated with susceptibility to cardiac damage in Chagas' disease. GeneRIF 6957

Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.

May E., Dulphy N., Frauendorf E., Duchmann R., Bowness P., Lopez de Castro J.A., Toubert A., Marker-Hermann E.

Tissue Antigens 60:299-308(2002) GeneRIF 6957 · Mapped (1,385)
Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen. GeneRIF 6957

Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements.

Wagner U., Pierer M., Kaltenhauser S., Wilke B., Seidel W., Arnold S., Hantzschel H.

Eur. J. Immunol. 33:79-84(2003) GeneRIF 6957 · Mapped (1)
Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements GeneRIF 6957

Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host.

Kunstmann E., Hardt C., Crabtree J.E., Suerbaum S., Epplen J.T.

Int. J. Med. Microbiol. 292:537-540(2003) GeneRIF 6957 · Mapped (459)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6957

T cell receptor transfection shows non-HLA-restricted recognition of nickel by CD8+ human T cells to be mediated by alphabeta T cell receptors.

Moulon C., Choleva Y., Thierse H.J., Wild D., Weltzien H.U.

J. Invest. Dermatol. 121:496-501(2003) GeneRIF 6957 · Mapped (19)
T cell receptor itself is necessary and sufficient to confer HLA-independent nickel specificity GeneRIF 6957

T-cell receptor polymorphism in primary biliary cirrhosis.

Selmi C., Invernizzi P., Tripputi P., Battezzati P.M., Bignotto M., Zuin M., Crosignani A., Podda M.

Ann. Ital. Med. Int. 18:149-153(2003) GeneRIF 6957 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6957

Analysis of two T-cell receptor BV gene segment polymorphisms in caucasoid Brazilian patients with rheumatoid arthritis.

Dresch C., Xavier R., Brenol J.C., Nardi N.B., Chies J.A.

Immunol. Lett. 90:77-80(2003) GeneRIF 6957 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6957

Mutations of the T-cell receptor constant region after in utero stem cell transplantation.

Pirovano S., Notarangelo L.D., Valotti M., Ugazio A.G., Albertini A., Imberti L.

Immunogenetics 56:214-219(2004) GeneRIF 6957 · Mapped (1)
Constant region mutations of the T-cell receptor beta gene after in utero stem cell transplantation. GeneRIF 6957

Matching T-cell receptors identified in renal biopsies and urine at the time of acute rejection in pediatric renal transplant patients.

Hu M., Zhang G.Y., Walters G., Sartor M., Watson D., Knight J.F., Alexander S.I.

Am. J. Transplant. 4:1859-1868(2004) GeneRIF 6957 · Mapped (1)
Urinaary monitoring can detect graft-infiltrating lymphocytes in acute rejection vby asssessing T cell receptors. GeneRIF 6957

Nonsense-associated alternative splicing of T-cell receptor beta genes: no evidence for frame dependence.

Mohn F., Buhler M., Muhlemann O.

RNA 11:147-156(2005) GeneRIF 6957 · Mapped (1)
frame dependence of the nonsense-associated altered splicing of TCR-beta pre-mRNA GeneRIF 6957

Analysis of the insertion/deletion related polymorphism within T cell antigen receptor beta variable genes in primary Sjogren's syndrome.

Lawson C.A., Donaldson I.J., Bowman S.J., Shefta J., Morgan A.W., Gough A., Isaacs J.D., Griffiths B., Emery P., Pease C.T. et al.

Ann. Rheum. Dis. 64:468-470(2005) GeneRIF 6957 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6957

Rearrangement of T-cell receptor beta and gamma genes in thymoma.

Nakajima J., Matsumoto J., Takeuchi E., Fukami T., Takamoto S.

Asian Cardiovasc Thorac Ann 13:149-152(2005) GeneRIF 6957 · Mapped (2)
Appearance of clonal bands on Southern blot analysis of TCR beta and gamma genes implies that the TIL in thymomas experience partial gene rearrangement just before the connection between the DJC complex and a locus of the V region GeneRIF 6957

Extensive T cell receptor cross-reactivity on structurally diverse haptenated peptides presented by HLA-A2.

Gagnon S.J., Turner R.V., Shiue M.G., Damirjian M., Biddison W.E.

Mol. Immunol. 43:346-356(2006) GeneRIF 6957 · Mapped (653)
Hapten cross-reactivity happens w/o major adjustments to the interaction between the TCR & the HLA-A2 surface. TCRs have the molecular flexibility to accommodate structurally diverse ligands while conserving interactions with the MHC molecule surface. GeneRIF 6957

Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice.

Joachims M.L., Chain J.L., Hooker S.W., Knott-Craig C.J., Thompson L.F.

J. Immunol. 176:1543-1552(2006) GeneRIF 6957 · Mapped (26)
Data are compatible with an instructive role for the TCR in alphabeta vs gammadelta lineage commitment with gammadelta development as the default pathway for human thymocyte development. GeneRIF 6957

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