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APOE and APOC1 genetic polymorphisms in age-associated memory impairment.

Bartres-Faz D., Clemente I.C., Junque C., Valveny N., Lopez-Alomar A., Sanchez-Aldeguer J., Lopez-Guillen A., Moral P.

Neurogenetics 3:215-219(2001) GAD 116988 · Mapped (5)
Associated with AGING: age-associated memory impairment; GAD 116988

APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals.

Tycko B., Lee J.H., Ciappa A., Saxena A., Li C.M., Feng L., Arriaga A., Stern Y., Lantigua R., Shachter N. et al.

Arch. Neurol. 61:1434-1439(2004) GAD 116999 GeneRIF 341 · Mapped (7)
Not Associated with NEUROLOGICAL: Alzheimer's Disease; GAD 116999 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 341

The common insertional polymorphism in the APOC1 promoter is associated with serum apolipoprotein C-I levels in Hispanic children.

Shachter N.S., Rabinowitz D., Stohl S., Conde-Knape K., Cohn J.S., Deckelbaum R.J., Berglund L., Shea S.

Atherosclerosis 179:387-393(2005) GAD 116995 GeneRIF 341 · Mapped (2)
Associated with METABOLIC: lipoprotein; GAD 116995 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 341

Combined effects of apoE-CI-CII cluster and LDL-R gene polymorphisms on chromosome 19 and coronary artery disease risk.

Wang C., Zhou X., Ye S., Han D., Tan X., Zheng F., Shi Q.

Int J Hyg Environ Health 209:265-273(2006) GAD 144426 GeneRIF 341 · Mapped (19)
Associated with CARDIOVASCULAR: atherosclerosis, coronary; GAD 144426 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator); ApoCI polymorphism is related to coronary disease in the Chinese Han population with smoking and alcohol drinking increasing the genetic predisposition to disease. GeneRIF 341

Candidate gene polymorphism in cardiovascular disease: the BIP cohort.

Leshinsky-Silver E., Cheng S., Grow M.A., Shoshana S., Scharf L., Lev D., Boaz M., Brunner D., Zimlichman R.

Isr. Med. Assoc. J. 8:103-105(2006) GAD 144427 · Mapped (58)
Associated with CARDIOVASCULAR: cardiovascular disease; GAD 144427

Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants.

Klos K.L., Sing C.F., Boerwinkle E., Hamon S.C., Rea T.J., Clark A., Fornage M., Hixson J.E.

Arterioscler. Thromb. Vasc. Biol. 26:1828-1836(2006) GAD 144430 GeneRIF 341 · Mapped (65)
Not Associated with CARDIOVASCULAR: cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides; GAD 144430 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 341

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

Willer C.J., Sanna S., Jackson A.U., Scuteri A., Bonnycastle L.L., Clarke R., Heath S.C., Timpson N.J., Najjar S.S., Stringham H.M. et al.

Nat. Genet. 40:161-169(2008) GAD 596855 · Mapped (122)
Associated with METABOLIC: LDL cholesterol; GAD 596855

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

Kathiresan S., Melander O., Guiducci C., Surti A., Burtt N.P., Rieder M.J., Cooper G.M., Roos C., Voight B.F., Havulinna A.S. et al.

Nat. Genet. 40:189-197(2008) GAD 596854 · Mapped (135)
Associated with METABOLIC: LDL cholesterol; GAD 596854

LDL-cholesterol concentrations: a genome-wide association study.

Wellcome Trust Case Control Consortium
Sandhu M.S., Waterworth D.M., Debenham S.L., Wheeler E., Papadakis K., Zhao J.H., Song K., Yuan X., Johnson T., Ashford S. et al.

Lancet 371:483-491(2008) GAD 596853 · Mapped (21)
Associated with METABOLIC: LDL cholesterol; GAD 596853

Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.

Burkhardt R., Kenny E.E., Lowe J.K., Birkeland A., Josowitz R., Noel M., Salit J., Maller J.B., Pe'er I., Daly M.J. et al.

Arterioscler. Thromb. Vasc. Biol. 28:2078-2084(2008) GAD 596852 · Mapped (16)
Associated with METABOLIC: LDL cholesterol; GAD 596852

Common variants at 30 loci contribute to polygenic dyslipidemia.

Kathiresan S., Willer C.J., Peloso G.M., Demissie S., Musunuru K., Schadt E.E., Kaplan L., Bennett D., Li Y., Tanaka T. et al.

Nat. Genet. 41:56-65(2009) GAD 596851 · Mapped (191)
Associated with METABOLIC: LDL cholesterol; GAD 596851

Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

Lowe J.K., Maller J.B., Pe'er I., Neale B.M., Salit J., Kenny E.E., Shea J.L., Burkhardt R., Smith J.G., Ji W. et al.

PLoS Genet. 5:e1000365-e1000365(2009) GAD 596848 GAD 596849 GAD 596850 · Mapped (76)
Associated with OTHER: quantitative traits; GAD 596848 GAD 596849 GAD 596850

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

Elliott P., Chambers J.C., Zhang W., Clarke R., Hopewell J.C., Peden J.F., Erdmann J., Braund P., Engert J.C., Bennett D. et al.

JAMA 302:37-48(2009) GAD 596847 GeneRIF 341 · Mapped (33)
Associated with METABOLIC: C-reactive protein; GAD 596847 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) GeneRIF 341

APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians.

Lahiry P., Cao H., Ban M.R., Pollex R.L., Mamakeesick M., Zinman B., Harris S.B., Hanley A.J., Huff M.W., Connelly P.W. et al.

J. Lipid Res. 51:843-848(2010) GAD 585089 GeneRIF 341 · Mapped (2)
Associated with METABOLIC: obesity; GAD 585089 Observational study of gene-disease association. (HuGE Navigator); From genetic association studies in Canadian Oji-Cree subjects APOC1 T45S polymorphism may be linked to obesity adipocyte regulation body fat waist circumference hyperglycemia and plasma leptin and apolipoprotein C-I levels. GeneRIF 341

Potential genetic markers of sporadic Alzheimer's dementia.

Retz W., Thome J., Durany N., Harsanyi A., Retz-Junginger P., Kornhuber J., Riederer P., Rosler M.

Psychiatr. Genet. 11:115-122(2001) GeneRIF 341 · Mapped (29)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 341

Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease.

Ki C.S., Na D.L., Kim D.K., Kim H.J., Kim J.W.

Neurosci. Lett. 319:75-78(2002) GeneRIF 341 GAD 116987 GAD 116992 · Mapped (3)
Associated with NEUROLOGICAL: Alzheimer's Disease; GAD 116987 GAD 116992 Observational study of gene-disease association. (HuGE Navigator); APOC1 might be an additional susceptibility gene for late onset Alzheimer disease. GeneRIF 341

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.

Mak P.A., Laffitte B.A., Desrumaux C., Joseph S.B., Curtiss L.K., Mangelsdorf D.J., Tontonoz P., Edwards P.A.

J. Biol. Chem. 277:31900-31908(2002) GeneRIF 341 · Mapped (37)
regulated expression of gene cluster in macrophages GeneRIF 341

Complex of human apolipoprotein C-1 with phospholipid: thermodynamic or kinetic stability?

Gursky O., Ranjana, Gantz D.L.

Biochemistry 41:7373-7384(2002) GeneRIF 341 · Mapped (2)
Thermal unfolding of discoidal complexes of apolipoprotein (apo) C-1 with dimyristoyl phosphatidylcholine (DMPC) reveals a novel mechanism of lipoprotein stabilization that is based on kinetics rather than thermodynamics. GeneRIF 341

Relationship among (1)H-magnetic resonance spectroscopy, brain volumetry and genetic polymorphisms in humans with memory impairment.

Bartres-Faz D., Junque C., Clemente I.C., Lopez-Alomar A., Bargallo N., Mercader J.M., Moral P.

Neurosci. Lett. 327:177-180(2002) GeneRIF 341 · Mapped (19)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 341

Apolipoprotein molecular variation in Moroccan Berbers: pentanucleotide (TTTTA)n repeat in the LPA gene and APOE-C1-C2 gene cluster.

Harich N., Esteban E., Lopez-Alomar A., Chafik A., Moral P.

Clin. Genet. 62:240-244(2002) GeneRIF 341 · Mapped (16)
Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 341

An improved RSP method to detect HpaI polymorphism in the apolipoprotein C-1 gene promoter.

Gao L., Gabriel C., Lavoie T., Ye S.Q.

BMC Med. Genet. 3:13-13(2002) GeneRIF 341 · Mapped (2)
Observational study of genetic testing. (HuGE Navigator) GeneRIF 341

Apolipoprotein E and apolipoprotein CI polymorphisms in the Czech population: almost complete linkage disequilibrium of the less frequent alleles of both polymorphisms.

Hubacek J.A., Pitha J., Adamkova V., Skodova Z., Lanska V., Poledne R.

Physiol Res 52:195-200(2003) GeneRIF 341 · Mapped (7)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 341

Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins.

Mehta R., Gantz D.L., Gursky O.

Biochemistry 42:4751-4758(2003) GeneRIF 341 · Mapped (2)
Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins. GeneRIF 341

Apolipoproteins E and C1 and brain morphology in memory impaired elders.

Serra-Grabulosa J.M., Salgado-Pineda P., Junque C., Sole-Padulles C., Moral P., Lopez-Alomar A., Lopez T., Lopez-Guillen A., Bargallo N., Mercader J.M. et al.

Neurogenetics 4:141-146(2003) GeneRIF 341 · Mapped (7)
The effect of APOC1 genes on brain MRI measures were studied in subjects with age-associated memory impairment. The effects of APOC1 on hippocampal volumes appeared to be more robust than those of the APOE polymorphism; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 341

Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism.

Cohn J.S., Tremblay M., Boulet L., Jacques H., Davignon J., Roy M., Bernier L.

Atherosclerosis 169:63-70(2003) GeneRIF 341 · Mapped (2)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 341

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