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Solution structure of the E. coli 70S ribosome at 11.5 A resolution.

Gabashvili I.S., Agrawal R.K., Spahn C.M., Grassucci R.A., Svergun D.I., Frank J., Penczek P.

Cell 100:537-549(2000) PDB 1EG0 · UniProtKB (1) · Mapped (10)

Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements.

Mitra K., Schaffitzel C., Fabiola F., Chapman M.S., Ban N., Frank J.

Mol. Cell 22:533-543(2006) PDB 2GY9 PDB 2GYB · Mapped (45)

A model for co-translational translocation: ribosome-regulated nascent polypeptide translocation at the protein-conducting channel.

Mitra K., Frank J.

FEBS Lett. 580:3353-3360(2006) PDB 2GY9 PDB 2GYB · Mapped (45)

Structural analysis of kasugamycin inhibition of translation.

Schuwirth B.S., Day J.M., Hau C.W., Janssen G.R., Dahlberg A.E., Cate J.H., Vila-Sanjurjo A.

Nat. Struct. Mol. Biol. 13:879-886(2006) PDB 1VS7 PDB 1VS5 · Mapped (49)

Structural basis for mRNA and tRNA positioning on the ribosome.

Berk V., Zhang W., Pai R.D., Cate J.H., Cate J.H.

Proc. Natl. Acad. Sci. U.S.A. 103:15830-15834(2006) PDB 2I2U PDB 2I2P · Mapped (49)

Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.

Borovinskaya M.A., Pai R.D., Zhang W., Schuwirth B.S., Holton J.M., Hirokawa G., Kaji H., Kaji A., Cate J.H.

Nat. Struct. Mol. Biol. 14:727-732(2007) PDB 2QBH PDB 2QAN PDB 2QAL PDB 2QBF PDB 2QBD PDB 2QBB PDB 2QB9 PDB 2QBJ PDB 2Z4K PDB 2Z4M · Mapped (50)

A steric block in translation caused by the antibiotic spectinomycin.

Borovinskaya M.A., Shoji S., Holton J.M., Fredrick K., Cate J.H.

ACS Chem. Biol. 2:545-552(2007) PDB 2QOU PDB 2QOW PDB 2QP0 PDB 2QOY · Mapped (49)

A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing.

Bingel-Erlenmeyer R., Kohler R., Kramer G., Sandikci A., Antolic S., Maier T., Schaffitzel C., Wiedmann B., Bukau B., Ban N.

Nature 452:108-111(2008) PDB 2VHP PDB 2VHO · Mapped (53)

Structural basis for hygromycin B inhibition of protein biosynthesis.

Borovinskaya M.A., Shoji S., Fredrick K., Cate J.H.

RNA 14:1590-1599(2008) PDB 3DF1 PDB 3DF3 · Mapped (49)

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis.

Villa E., Sengupta J., Trabuco L.G., LeBarron J., Baxter W.T., Shaikh T.R., Grassucci R.A., Nissen P., Ehrenberg M., Schulten K. et al.

Proc. Natl. Acad. Sci. U.S.A. 106:1063-1068(2009) PDB 3FIH · Mapped (51)

Structures of the ribosome in intermediate states of ratcheting.

Zhang W., Dunkle J.A., Cate J.H.

Science 325:1014-1017(2009) PDB 3I1O PDB 3I1M PDB 3I1Q PDB 3I21 PDB 3I1Z PDB 3I1S · Mapped (49)

Regulation of the protein-conducting channel by a bound ribosome.

Gumbart J., Trabuco L.G., Schreiner E., Villa E., Schulten K.

Structure 17:1453-1464(2009) PDB 3KC4 · UniProtKB (3) · Mapped (50)

Structural insight into nascent polypeptide chain-mediated translational stalling.

Seidelt B., Innis C.A., Wilson D.N., Gartmann M., Armache J.P., Villa E., Trabuco L.G., Becker T., Mielke T., Schulten K. et al.

Science 326:1412-1415(2009) PDB 2WWL · Mapped (50)

Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.

Llano-Sotelo B., Dunkle J., Klepacki D., Zhang W., Fernandes P., Cate J.H., Mankin A.S.

Antimicrob. Agents Chemother. 54:4961-4970(2010) PDB 3OR9 PDB 3ORA · Mapped (49)

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.

Dunkle J.A., Xiong L., Mankin A.S., Cate J.H.

Proc. Natl. Acad. Sci. U.S.A. 107:17152-17157(2010) PDB 3OFY PDB 3OAQ PDB 3OAR PDB 3OFA PDB 3OFB PDB 3OFO PDB 3OFP PDB 3OFX · Mapped (49)

Structural insights into cognate versus near-cognate discrimination during decoding.

Agirrezabala X., Schreiner E., Trabuco L.G., Lei J., Ortiz-Meoz R.F., Schulten K., Green R., Frank J.

EMBO J. 30:1497-1507(2011) PDB 3IZV PDB 3IZW · Mapped (51)

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.

Frauenfeld J., Gumbart J., Sluis E.O., Funes S., Gartmann M., Beatrix B., Mielke T., Berninghausen O., Becker T., Schulten K. et al.

Nat. Struct. Mol. Biol. 18:614-621(2011) PDB 3J00 · UniProtKB (5) · Mapped (49)

Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.

Dunkle J.A., Wang L., Feldman M.B., Pulk A., Chen V.B., Kapral G.J., Noeske J., Richardson J.S., Blanchard S.C., Cate J.H.

Science 332:981-984(2011) PDB 4GD1 PDB 4GD2 · Mapped (50)

Structural basis for the function of a small GTPase RsgA on the 30S ribosomal subunit maturation revealed by cryoelectron microscopy.

Guo Q., Yuan Y., Xu Y., Feng B., Liu L., Chen K., Sun M., Yang Z., Lei J., Gao N.

Proc. Natl. Acad. Sci. U.S.A. 108:13100-13105(2011) PDB 2YKR · Mapped (16)

Cryo-electron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factor.

Jomaa A., Stewart G., Mears J.A., Kireeva I., Brown E.D., Ortega J.

RNA 17:2026-2038(2011) PDB 4A2I · Mapped (21)

Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome.

Zhou J., Lancaster L., Trakhanov S., Noller H.F.

RNA 18:230-240(2012) PDB 3SFS PDB 3UOQ · Mapped (51)

Structural insights into methyltransferase KsgA function in 30S ribosomal subunit biogenesis.

Boehringer D., O'Farrell H.C., Rife J.P., Ban N.

J. Biol. Chem. 287:10453-10459(2012) PDB 4ADV · Mapped (21)

Structural characterization of mRNA-tRNA translocation intermediates.

Agirrezabala X., Liao H.Y., Schreiner E., Fu J., Ortiz-Meoz R.F., Schulten K., Green R., Frank J.

Proc. Natl. Acad. Sci. U.S.A. 109:6094-6099(2012) PDB 3J0U PDB 3J0V PDB 3J0X PDB 3J0Z PDB 3J10 PDB 3J13 · Mapped (52)

The complex of tmRNA-SmpB and EF-G on translocating ribosomes.

Ramrath D.J., Yamamoto H., Rother K., Wittek D., Pech M., Mielke T., Loerke J., Scheerer P., Ivanov P., Teraoka Y. et al.

Nature 485:526-529(2012) PDB 3J18 · Mapped (49)

Allosteric control of the ribosome by small-molecule antibiotics.

Wang L., Pulk A., Wasserman M.R., Feldman M.B., Altman R.B., Cate J.H., Blanchard S.C.

Nat. Struct. Mol. Biol. 19:957-963(2012) PDB 4GAQ PDB 4GAS · Mapped (50)

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