Leroux L., Durel B., Autier V., Deltour L., Bucchini D., Jami J., Joshi R.L.

Int J Exp Diabesity Res 4:7-12(2003) GeneRIF 16334 · Mapped (3)
Transcriptional up-regulation of the remaining functional insulin gene in Ins2-/- mice could potentially contribute to beta-cell adaptation. GeneRIF 16334

Zuber C., Fan J.Y., Guhl B., Roth J.

FASEB J. 18:917-919(2004) GeneRIF 16334 MGI 96573 · Mapped (7)
A missense mutation of the insulin 2 gene (Cys96Tyr) disrupts 1 of the 2 interchain disulfide bonds resulting in accumulation of misfolded protein in pre-Golgi intermediates. GeneRIF 16334

Cirri P., Taddei M.L., Chiarugi P., Buricchi F., Caselli A., Paoli P., Giannoni E., Camici G., Manao G., Raugei G. et al.

Mol. Biol. Cell 16:73-83(2005) GeneRIF 16334 · Mapped (19)
platelet-derived growth factor-induced cell proliferation is inhibited by insulin GeneRIF 16334

Greenman I.C., Gomez E., Moore C.E., Herbert T.P.

Biochem. J. 391:291-300(2005) GeneRIF 16334 · Mapped (3)
Pancreatic beta-cells that glucose stimulates the recruitment of ribosome-associated proinsulin mRNA located in the cytoplasm to the ER the site of proinsulin synthesis; this plays an important role in glucose-stimulated proinsulin synthesis. GeneRIF 16334

Faideau B., Lotton C., Lucas B., Tardivel I., Elliott J.F., Boitard C., Carel J.C.

J. Immunol. 177:53-60(2006) GeneRIF 16334 MGI 96573 · Mapped (10)
Proinsulin-2 gene expression by radioresistant thymic epithelial cells is involved in the induction of self-tolerance and additional factors are required to induce islet abnormalities. GeneRIF 16334

Herbach N., Rathkolb B., Kemter E., Pichl L., Klaften M., de Angelis M.H., Halban P.A., Wolf E., Aigner B., Wanke R.

Diabetes 56:1268-1276(2007) GeneRIF 16334 MGI 96573 · Mapped (7)
Munich Ins2 mutant mice are a valuable model to study the mechanisms of beta-cell dysfunction and death during development of diabetes. GeneRIF 16334

Fujimiya M., Kojima H., Ichinose M., Arai R., Kimura H., Kashiwagi A., Chan L.

Proc. Natl. Acad. Sci. U.S.A. 104:4030-4035(2007) GeneRIF 16334 · Mapped (3)
diabetes causes fusion between Proins-P bone marrow-derived cells and hepatocytes GeneRIF 16334

Pomplun D., Florian S., Schulz T., Pfeiffer A.F., Ristow M.

Horm. Metab. Res. 39:336-340(2007) GeneRIF 16334 · Mapped (3)
Cre recombinase is controlled by a short fragment of the rat insulin II gene promoter GeneRIF 16334

Fan J.Y., Roth J., Zuber C.

Histochem. Cell Biol. 128:161-173(2007) GeneRIF 16334 · Mapped (3)
misfolded proinsulin causes enlargement of pre-Golgi intermediates which indicates their involvement in protein quality control. GeneRIF 16334

Hong E.G., Jung D.Y., Ko H.J., Zhang Z., Ma Z., Jun J.Y., Kim J.H., Sumner A.D., Vary T.C., Gardner T.W. et al.

Am. J. Physiol. Endocrinol. Metab. 293:E1687-96(2007) GeneRIF 16334 MGI 96573 · Mapped (7)
Nonobese insulin-deficient Ins2(Akita) mice develop type 2 diabetes phenotypes including peripheral and hepatic insulin resistance and cardiac remodeling. GeneRIF 16334

Hu Z., MacLean J.A., Bhardwaj A., Wilkinson M.F.

Ann. N. Y. Acad. Sci. 1120:72-83(2007) GeneRIF 16334 · Mapped (10)
Insulin II is a direct target of RHOX5. GeneRIF 16334

Shiao M.S., Liao B.Y., Long M., Yu H.T.

Genetics 178:1683-1691(2008) GeneRIF 16334 · UniProtKB (10) · Mapped (5)
The data suggest an adaptive divergence in the mouse insulin two-gene system which may result from the response to environmental change caused by the rise of agricultural civilization as proposed by the thrifty-genotype hypothesis. GeneRIF 16334

Lipson K.L., Ghosh R., Urano F.

PLoS ONE 3:e1648-e1648(2008) GeneRIF 16334 · Mapped (9)
a role of IRE1alpha in insulin mRNA expression under ER stress conditions caused by chronic high glucose GeneRIF 16334

Yang X.Q., Wang Y.Y., Chen A.F.

Clin. Exp. Pharmacol. Physiol. 35:1097-1103(2008) GeneRIF 16334 · Mapped (3)
Arterial superoxide generated from diverse sources may potentiate the contractions of carotid arteries in Ins2(Akita) diabetic mice. GeneRIF 16334

Yamada K., Moriyama H., Okumachi Y., Arai T., Kameno M., Kishi M., Yasuda H., Hara K., Yokono K., Nagata M.

Ann. N. Y. Acad. Sci. 1150:183-186(2008) GeneRIF 16334 · Mapped (5)
Systemic administration of fiber-mutant adenovirus vectors which induce transient expression of proinsulin may be applicable to a gene therapy inducing tolerance to insulin. GeneRIF 16334

Smith R., Bacos K., Fedele V., Soulet D., Walz H.A., Obermuller S., Lindqvist A., Bjorkqvist M., Klein P., Onnerfjord P. et al.

Hum. Mol. Genet. 18:3942-3954(2009) GeneRIF 16334 · Mapped (9)
Mutant huntingtin disrupts intracellular transport and insulin secretion by interacting with tubulin beta 5. GeneRIF 16334

Basu R., Oudit G.Y., Wang X., Zhang L., Ussher J.R., Lopaschuk G.D., Kassiri Z.

Am. J. Physiol. Heart Circ. Physiol. 297:H2096-108(2009) GeneRIF 16334 MGI 96573 · Mapped (7)
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. GeneRIF 16334

Gurley S.B., Mach C.L., Stegbauer J., Yang J., Snow K.P., Hu A., Meyer T.W., Coffman T.M.

Am. J. Physiol. Renal Physiol. 298:F788-95(2010) GeneRIF 16334 MGI 96573 · Mapped (7)
These studies identify strong effects of genetic background to modify the renal phenotype associated with the Ins2(C96Y) mutation. GeneRIF 16334

Parrella E., Longo V.D.

ScientificWorldJournal 10:161-177(2010) GeneRIF 16334 · Mapped (29)
Studies indicate that insulin/IGF-I and other genes converge and play partially overlapping roles in regulating aging and stress resistance in higher eukaryotes. GeneRIF 16334

Panda A.C., Kulkarni S.D., Muralidharan B., Bakthavachalu B., Seshadri V.

FEBS Lett. 584:1169-1173(2010) GeneRIF 16334 MGI 96573 · Mapped (7)
Alternative splicing of insulin mRNA in mice could result in an additional level of regulation in insulin biosynthesis. GeneRIF 16334

de Preux Charles A.S., Verdier V., Zenker J., Peter B., Medard J.J., Kuntzer T., Beckmann J.S., Bergmann S., Chrast R.

PLoS ONE 5:e10832-e10832(2010) GeneRIF 16334 MGI 96573 · Mapped (7)
The transcriptional programs in both endoneurial and neuronal compartments of the peripheral nerve are relatively resistant to the onset of hyperglycemia and hypoinsulinemia in Ins2 mice. GeneRIF 16334

Meur G., Qian Q., da Silva Xavier G., Pullen T.J., Tsuboi T., McKinnon C., Fletcher L., Tavare J.M., Hughes S., Johnson P. et al.

J. Biol. Chem. 286:13647-13656(2011) GeneRIF 16334 · UniProtKB (1) · Mapped (9)
nuclear import of FoxO1 contributes to the suppression of Pdx1 and Ins2 gene expression at low glucose the latter via a previously unsuspected and direct physical interaction with the Ins2 promoter. GeneRIF 16334

Sampley M.L., Ozcan S.

DNA Cell Biol. 31:8-14(2012) GeneRIF 16334 · Mapped (15)
Data suggest that high glucose mediates the recruitment of p300 CBP PCAF and GCN5 to the insulin promoter and that all four histone acetyltransferase (HATs) are important for insulin gene expression. GeneRIF 16334

Vargas N., Alvarez-Cubela S., Giraldo J.A., Nieto M., Fort N.M., Cechin S., Garcia E., Espino-Grosso P., Fraker C.A., Ricordi C. et al.

PLoS ONE 6:e22364-e22364(2011) GeneRIF 16334 · Mapped (5)
Data show that when injected in utero into living mouse embryos TAT-MafA significantly up-regulates target genes and induces enhanced insulin production as well as cytoarchitectural changes consistent with faster islet maturation. GeneRIF 16334

Diiorio P., Jurczyk A., Yang C., Racki W.J., Brehm M.A., Atkinson M.A., Powers A.C., Shultz L.D., Greiner D.L., Bortell R.

Pancreas 40:1147-1149(2011) GeneRIF 16334 · Mapped (14)
Letter: Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rgammanull Ins2Akita mice. GeneRIF 16334