Day I.N., Chen X.H., Gaunt T.R., King T.H., Voropanov A., Ye S., Rodriguez S., Syddall H.E., Sayer A.A., Dennison E.M. et al.

J. Clin. Endocrinol. Metab. 89:5569-5576(2004) GAD 123925 GeneRIF 2689 · Mapped (12)
Associated with METABOLIC: metabolic syndrome; GAD 123925 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 2689

Graichen R., Liu D., Sun Y., Lee K.O., Lobie P.E.

J. Biol. Chem. 277:26662-26672(2002) GeneRIF 2689 · Mapped (11)
report that autocrine hGH production by mammary carcinoma cells specifically results in the transcriptional repression of the p53-regulated placental transforming growth factor-beta gene (Placental growth factor-beta; TGF-beta) GeneRIF 2689

Silva C.M., Kloth M.T., Lyons C.E., Dunn C.R., Kirk S.E.

Growth Horm. IGF Res. 12:374-380(2002) GeneRIF 2689 · Mapped (3)
GH-V plays a major role in affecting target cells expressing the GH receptor thus potentially exerting significant GH-like effects on maternal physiology during pregnancy. GeneRIF 2689

Pal G., Kossiakoff A.A., Sidhu S.S.

J. Mol. Biol. 332:195-204(2003) GeneRIF 2689 · Mapped (3)
Data show that improved binding affinity of human growth hormone (hGH(v)) results from numerous small contributions distributed broadly over the interface. GeneRIF 2689

Walsh S.T., Sylvester J.E., Kossiakoff A.A.

Proc. Natl. Acad. Sci. U.S.A. 101:17078-17083(2004) GeneRIF 2689 · Mapped (7)
Using a mutagenesis-scanning analysis of 81 single and 32 pairwise double mutations it is shown that the GHv hormone's two spatially distal receptor binding sites (Site1 and Site2) are allosterically coupled GeneRIF 2689

Lacroix M.C., Guibourdenche J., Fournier T., Laurendeau I., Igout A., Goffin V., Pantel J., Tsatsaris V., Evain-Brion D.

Endocrinology 146:2434-2444(2005) GeneRIF 2689 · Mapped (3)
results offer the first evidence for a placental role of human placental growth hormone(hPGH) and suggest an autocrine/paracrine role of hPGH in the regulation of trophoblast invasion GeneRIF 2689

Mittal P., Espinoza J., Hassan S., Kusanovic J.P., Edwin S.S., Nien J.K., Gotsch F., Than N.G., Erez O., Mazaki-Tovi S. et al.

J. Matern. Fetal. Neonatal. Med. 20:651-659(2007) GeneRIF 2689 · Mapped (3)
PGH may play a role in the mechanisms of disease in preeclampsia and fetal growth restriction. GeneRIF 2689

Zeck W., Widberg C., Maylin E., Desoye G., Lang U., McIntyre D., Prins J., Russell A.

Pediatr. Res. 63:353-357(2008) GeneRIF 2689 · Mapped (8)
Placental growth hormone (PGH) secretion by BeWo cells is regulated by hormonal factors and adipokines. Elevated insulin and leptin levels might down-regulate PGH secretion. GeneRIF 2689

Christiansen M.

Prenat. Diagn. 29:1249-1255(2009) GeneRIF 2689 · Mapped (7)
early first trimester maternal serum marker for Down syndrome GeneRIF 2689

de Jesus Romero-Prado M.M., Barrera-Saldana H.A., Castrillo-Diez J.L.

Gene 452:7-15(2010) GeneRIF 2689 · Mapped (3)
The hGH-V promoter activity and the endogenous mRNA expression in human placental choriocarcinoma cell line JAR in the presence of glucose and demethylating genome conditions were compared. GeneRIF 2689

McElholm A.R., McKnight A.J., Patterson C.C., Johnston B.T., Hardie L.J., Murray L.J.

Gastroenterology 139:204-12.e3(2010) GeneRIF 2689 · Mapped (24)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2689

Higgins M.F., Russell N.E., Crossey P.A., Nyhan K.C., Brazil D.P., McAuliffe F.M.

PLoS ONE 7:e29164-e29164(2012) GeneRIF 2689 · Mapped (27)
These results suggest that the normal PGH-IGF-I-IGFBP3 axis in pregnancy is abnormal in Type 1 Diabetic pregnancies. GeneRIF 2689

Mannik J., Vaas P., Rull K., Teesalu P., Laan M.

Mol. Cell. Endocrinol. 355:180-187(2012) GeneRIF 2689 · Mapped (5)
results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism. GeneRIF 2689

Sifakis S., Akolekar R., Kappou D., Mantas N., Nicolaides K.H.

J. Matern. Fetal. Neonatal. Med. 25:1796-1799(2012) GeneRIF 2689 · Mapped (3)
Maternal serum PGH at 11-13 weeks' gestation is unlikely to be a useful biochemical marker for early prediction of small for gestational age neonates. GeneRIF 2689