Lossi A.M., Laugier-Anfossi F., Depetris D., Gecz J., Gedeon A., Kooy F., Schwartz C., Mattei M.G., Croquette M.F., Villard L.

J. Med. Genet. 39:113-117(2002) GeneRIF 11279 · Mapped (2)
The gene KLF8 is abnormally expressed in a female patient with X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. GeneRIF 11279

Kanazawa A., Kawamura Y., Sekine A., Iida A., Tsunoda T., Kashiwagi A., Tanaka Y., Babazono T., Matsuda M., Kawai K. et al.

Diabetologia 48:1315-1322(2005) GeneRIF 11279 · Mapped (29)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 11279

Zhang P., Basu P., Redmond L.C., Morris P.E., Rupon J.W., Ginder G.D., Lloyd J.A.

Blood Cells Mol. Dis. 35:227-235(2005) GeneRIF 11279 · Mapped (11)
In co-transfection assays in K562 cells it was demonstrated that KLF2 5 and 13 positively regulate and KLF8 negatively regulates the gamma-globin gene through the CACCC promoter element. GeneRIF 11279

Wang X., Zhao J.

Oncogene 26:456-461(2007) GeneRIF 11279 · Mapped (2)
Over expression of KLF8 is associated with cancer GeneRIF 11279

Hu J.H., Navas P., Cao H., Stamatoyannopoulos G., Song C.Z.

J. Mol. Biol. 366:1064-1073(2007) GeneRIF 11279 · Mapped (9)
Functional studies using RNA interference revealed that the silencing of Sp1 and KLF8 resulted in elevated level of gamma globin expression in K562 cells. GeneRIF 11279

Wang X., Zheng M., Liu G., Xia W., McKeown-Longo P.J., Hung M.C., Zhao J.

Cancer Res. 67:7184-7193(2007) GeneRIF 11279 · Mapped (2)
Overexpression of Kruppel-like factor 8 is associated with epithelial to mesenchymal transition and epithelial cell invasion leading to breast cancer GeneRIF 11279

Wang X., Urvalek A.M., Liu J., Zhao J.

J. Biol. Chem. 283:13934-13942(2008) GeneRIF 11279 · Mapped (18)
FAK induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signaling pathway leading to the activation of KLF8 promoter by Sp1 GeneRIF 11279

Fu W.J., Li J.C., Wu X.Y., Yang Z.B., Mo Z.N., Huang J.W., Xia G.W., Ding Q., Liu K.D., Zhu H.G.

J. Cancer Res. Clin. Oncol. 136:1255-1265(2010) GeneRIF 11279 · Mapped (2)
KLF8 is possibly involved in regulating cell growth invasion apoptosis and proliferation of renal carcinoma cancer; blocking this protein may be a therapeutic strategy for this cancer. GeneRIF 11279

Li J.C., Yang X.R., Sun H.X., Xu Y., Zhou J., Qiu S.J., Ke A.W., Cui Y.H., Wang Z.J., Wang W.M. et al.

Gastroenterology 139:2146-2157.e12(2010) GeneRIF 11279 · Mapped (2)
KLF8 promotes hepatocellular carcinoma cell proliferation and invasion inhibits apoptosis and induces the epithelial-to-mesenchymal transition GeneRIF 11279

Wang X., Lu H., Urvalek A.M., Li T., Yu L., Lamar J., DiPersio C.M., Feustel P.J., Zhao J.

Oncogene 30:1901-1911(2011) GeneRIF 11279 · Mapped (9)
Immunohistochemical staining strongly correlated the co-expression of KLF8 and MMP9 with the patient tumor invasion metastasis and poor survival GeneRIF 11279

Lu H., Wang X., Li T., Urvalek A.M., Yu L., Li J., Zhu J., Lin Q., Peng X., Zhao J.

J. Biol. Chem. 286:20335-20344(2011) GeneRIF 11279 · Mapped (10)
PARP-1 as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization stability and functions. GeneRIF 11279

Schnell O., Romagna A., Jaehnert I., Albrecht V., Eigenbrod S., Juerchott K., Kretzschmar H., Tonn J.C., Schichor C.

PLoS ONE 7:e30429-e30429(2012) GeneRIF 11279 · Mapped (2)
Kruppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. GeneRIF 11279

Yang T., Cai S.Y., Zhang J., Lu J.H., Lin C., Zhai J., Wu M.C., Shen F.

PLoS ONE 7:e39668-e39668(2012) GeneRIF 11279 · Mapped (2)
Knockdown of beta-catenin by shRNA rescues the enhanced HepG2 and Hep3B cells proliferation ability induced by overexpression of KLF8 GeneRIF 11279

Chen G., Yang W., Jin W., Wang Y., Tao C., Yu Z.

Mol. Biol. Rep. 39:9809-9815(2012) GeneRIF 11279 · Mapped (2)
KLF8 is necessary for cell survival and invasion in gastric cancer cells. GeneRIF 11279