Seimiya H., Smith S.

J. Biol. Chem. 277:14116-14126(2002) GeneRIF 8658 · UniProtKB (1) · Mapped (10)
The telomeric poly(ADP-ribose) polymerase tankyrase 1 contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor 182-kDa tankyrase-binding protein (TAB182). GeneRIF 8658

Sbodio J.I., Chi N.W.

J. Biol. Chem. 277:31887-31892(2002) GeneRIF 8658 · Mapped (16)
Identification of a binding motif shared by IRAP TAB182 and human TRF1 but not mouse TRF1 GeneRIF 8658

Rippmann J.F., Damm K., Schnapp A.

J. Mol. Biol. 323:217-224(2002) GeneRIF 8658 · Mapped (5)
Results describe the expression and enzymatic characterization of full-length tankyrase 1 and a fragment termed T-PARP spanning the poly(ADP-ribose) polymerase domain. GeneRIF 8658

Bae J., Donigian J.R., Hsueh A.J.

J. Biol. Chem. 278:5195-5204(2003) GeneRIF 8658 · Mapped (11)
Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis GeneRIF 8658

Fuchs U., Rehkamp G.F., Slany R., Follo M., Borkhardt A.

FEBS Lett. 554:10-16(2003) GeneRIF 8658 · UniProtKB (2) · Mapped (9)
co-immunoprecipitation of endogenous proteins in 293T cells confirms physiological relevance of TNKS as interaction partner of FBP17 GeneRIF 8658

Seimiya H., Muramatsu Y., Smith S., Tsuruo T.

Mol. Cell. Biol. 24:1944-1955(2004) GeneRIF 8658 · Mapped (8)
Results provide evidence that specific ankyrin repeat cluster-TRF1 interactions play roles in the essential catalytic function of tankyrase 1. GeneRIF 8658

Dynek J.N., Smith S.

Science 304:97-100(2004) GeneRIF 8658 · Mapped (5)
telomeres may require a unique tankyrase 1-dependent mechanism for sister chromatid resolution before anaphase GeneRIF 8658

Ye J.Z., de Lange T.

Nat. Genet. 36:618-623(2004) GeneRIF 8658 · Mapped (21)
TIN2 protected TRF1 from poly(ADP-ribosyl)ation by tankyrase 1 without affecting tankyrase 1 automodification. GeneRIF 8658

Deng Z., Atanasiu C., Zhao K., Marmorstein R., Sbodio J.I., Chi N.W., Lieberman P.M.

J. Virol. 79:4640-4650(2005) GeneRIF 8658 · Mapped (6)
TNKS1 bound to Epstein-Barr virus origin of plasmid replication in coimmunoprecipitation experiments with transfected cell lysates. GeneRIF 8658

Yeh T.Y., Sbodio J.I., Nguyen M.T., Meyer T.N., Lee R.M., Chi N.W.

Mol. Cell. Biochem. 276:183-192(2005) GeneRIF 8658 · Mapped (5)
tankyrase-1 appears to protect cells by preventing genotoxins from activating PARP 1-mediated reactions such as PARP 1 automodification and NAD(+) consumption GeneRIF 8658

Yeh T.Y., Meyer T.N., Schwesinger C., Tsun Z.Y., Lee R.M., Chi N.W.

Biochem. J. 399:415-425(2006) GeneRIF 8658 · Mapped (5)
Cell-cell contact makes tankyrase associate with the lateral membrane. PARsylating activity causes translocation to cytosol ubiquitination & proteasomal degradation. Recruitment to this site suggests a role in polarized protein targeting in epithelium. GeneRIF 8658

Donigian J.R., de Lange T.

J. Biol. Chem. 282:22662-22667(2007) GeneRIF 8658 · Mapped (14)
tankyrase1 is a poly(ADP-ribose) polymerase with roles in telomere length control by the TRF1 component of the shelterin complex GeneRIF 8658

Shebzukhov Y.V., Lavrik I.N., Karbach J., Khlgatian S.V., Koroleva E.P., Belousov P.V., Kashkin K.N., Knuth A., Jager E., Chi N.W. et al.

Cancer Immunol. Immunother. 57:871-881(2008) GeneRIF 8658 · Mapped (6)
TNKL and TNKS are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients GeneRIF 8658

Baynam G., Goldblatt J., Walpole I.

Am. J. Med. Genet. A 146A:1565-1570(2008) GeneRIF 8658 · Mapped (5)
This paper suggests a novel candidate gene for Cornelia de Lange syndrome - tankyrase 1. GeneRIF 8658

Hosgood H.D., Menashe I., Shen M., Yeager M., Yuenger J., Rajaraman P., He X., Chatterjee N., Caporaso N.E., Zhu Y. et al.

Carcinogenesis 29:1938-1943(2008) GeneRIF 8658 · Mapped (1,837)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8658

Shen M., Vermeulen R., Rajaraman P., Menashe I., He X., Chapman R.S., Yeager M., Thomas G., Burdett L., Hutchinson A. et al.

Environ. Mol. Mutagen. 50:285-290(2009) GeneRIF 8658 · Mapped (1,842)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 8658

Hosgood H.D., Menashe I., He X., Chanock S., Lan Q.

Respir Med 103:1866-1870(2009) GeneRIF 8658 · Mapped (1,815)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8658

Guey L.T., Garcia-Closas M., Murta-Nascimento C., Lloreta J., Palencia L., Kogevinas M., Rothman N., Vellalta G., Calle M.L., Marenne G. et al.

Eur. Urol. 57:283-292(2010) GeneRIF 8658 · Mapped (1,940)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8658

Chang P., Coughlin M., Mitchison T.J.

Mol. Biol. Cell 20:4575-4585(2009) GeneRIF 8658 · Mapped (17)
Data suggest that pADPr provides a dynamic cross-linking function at spindle poles by extending from covalent modification sites on PARP-5a and NuMA and binding noncovalently to NuMA and that this function helps promote assembly of exactly two poles. GeneRIF 8658

Varadi V., Brendle A., Brandt A., Johansson R., Enquist K., Henriksson R., Svenson U., Tavelin B., Roos G., Hemminki K. et al.

Eur. J. Cancer 45:3008-3016(2009) GeneRIF 8658 · Mapped (22)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8658

Choi J.E., Kang H.G., Jang J.S., Choi Y.Y., Kim M.J., Kim J.S., Jeon H.S., Lee W.K., Cha S.I., Kim C.H. et al.

Cancer Epidemiol. Biomarkers Prev. 18:2773-2781(2009) GeneRIF 8658 · Mapped (17)
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) GeneRIF 8658

Appierto V., Tiberio P., Cavadini E., Casalini P., Cappelletti G., Formelli F.

Mol. Cancer Ther. 8:3360-3368(2009) GeneRIF 8658 · Mapped (34)
Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C Kif 2A Eg5 Tara tankyrase-1 centractin and TOGp. GeneRIF 8658

Shen J., Gammon M.D., Wu H.C., Terry M.B., Wang Q., Bradshaw P.T., Teitelbaum S.L., Neugut A.I., Santella R.M.

Cancer Epidemiol. Biomarkers Prev. 19:219-228(2010) GeneRIF 8658 · Mapped (19)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8658

Davila S., Froeling F.E., Tan A., Bonnard C., Boland G.J., Snippe H., Hibberd M.L., Seielstad M.

Genes Immun. 11:232-238(2010) GeneRIF 8658 · Mapped (4,258)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8658

Rose J.E., Behm F.M., Drgon T., Johnson C., Uhl G.R.

Mol. Med. 16:247-253(2010) GeneRIF 8658 · Mapped (10,283)
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 8658