| A genome-wide association study identifies protein quantitative trait loci (pQTLs). Melzer D., Perry J.R., Hernandez D., Corsi A.M., Stevens K., Rafferty I., Lauretani F., Murray A., Gibbs J.R., Paolisso G. et al.
PLoS Genet. 4:e1000072-e1000072(2008) GAD 597696 · Mapped (608)
Associated with OTHER: protein quantitative trait loci; GAD 597696 |
| Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis. Zhang X., Sun H., Danila D.C., Johnson S.R., Zhou Y., Swearingen B., Klibanski A.
J. Clin. Endocrinol. Metab. 87:1262-1267(2002) GeneRIF 10912 · Mapped (5)
a powerful growth suppressor controlling pituitary cell proliferation and the first identified gene whose expression is lost in the majority of human pituitary tumors. GeneRIF 10912 |
| GADD45gamma, down-regulated in 65% hepatocellular carcinoma (HCC) from 23 chinese patients, inhibits cell growth and induces cell cycle G2/M arrest for hepatoma Hep-G2 cell lines. Sun L., Gong R., Wan B., Huang X., Wu C., Zhang X., Zhao S., Yu L.
Mol. Biol. Rep. 30:249-253(2003) GeneRIF 10912 · Mapped (5)
Data show that GADD45 gamma mRNA expression is down-regulated in hepatocellular carcinoma and that GADD45 gamma causes cell cycle arrest at G2/M transition when transfected into Hep-G2 cells. GeneRIF 10912 |
| Gadd45gamma is androgen-responsive and growth-inhibitory in prostate cancer cells. Jiang F., Wang Z.
Mol. Cell. Endocrinol. 213:121-129(2004) GeneRIF 10912 · Mapped (5)
GADD45g induction by androgens requires new protein synthesis; overexpression of GADD45g inhibited cell growth and caused morphological changes in prostate cell lines arguing that GADD45g is involved in differentiation induced by androgens GeneRIF 10912 |
| NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Zerbini L.F., Wang Y., Czibere A., Correa R.G., Cho J.Y., Ijiri K., Wei W., Joseph M., Gu X., Grall F. et al.
Proc. Natl. Acad. Sci. U.S.A. 101:13618-13623(2004) GeneRIF 10912 · Mapped (15)
Inhibition of GADD45alpha and gamma in cancer cells by small interfering RNA abrogates apoptosis induction by the inhibitor of NF-kappaB GeneRIF 10912 |
| The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. Ying J., Srivastava G., Hsieh W.S., Gao Z., Murray P., Liao S.K., Ambinder R., Tao Q.
Clin. Cancer Res. 11:6442-6449(2005) GeneRIF 10912 · Mapped (5)
Results show that GADD45G can act as a functional new-age tumor suppressor but being frequently inactivated epigenetically in multiple tumors. GeneRIF 10912 |
| A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells. Zerbini L.F., Czibere A., Wang Y., Correa R.G., Otu H., Joseph M., Takayasu Y., Silver M., Gu X., Ruchusatsawat K. et al.
Cancer Res. 66:11922-11931(2006) GeneRIF 10912 · Mapped (7)
Establish MDA-7/IL-24 and GADD45alpha and GADD45gamma as critical mediators of apoptosis and growth arrest in response to NSAIDs in cancer cells. GeneRIF 10912 |
| Purification, crystallization and preliminary X-ray diffraction analysis of human Gadd45gamma. Zhang W., Zhao M., Li J., Li X., Zeng Z., Rao Z.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64:1070-1073(2008) GeneRIF 10912 · Mapped (5)
Human Gadd45gamma and its selenomethionine derivative were expressed in an Escherichia coli expression system and purified; they were then crystallized using the hanging-drop vapour-diffusion method. GeneRIF 10912 |
| Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells. Zhu N., Shao Y., Xu L., Yu L., Sun L.
Mol. Biol. Rep. 36:2075-2085(2009) GeneRIF 10912 · Mapped (7)
Flow cytometric analysis revealed significant G2/M arrest in cells transfected with either Gadd45alpha or Gadd45gamma. Importantly we found that expression of either Gadd45alpha or Gadd45gamma activated P38 and JNK kinase pathways to induce G2/M arrest. GeneRIF 10912 |
| Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Ovarian Cancer Association Consortium
Palmieri R.T., Wilson M.A., Iversen E.S., Clyde M.A., Calingaert B., Moorman P.G., Poole C., Anderson A.R., Anderson S., Anton-Culver H. et al.
Cancer Epidemiol. Biomarkers Prev. 17:3567-3572(2008) GeneRIF 10912 · Mapped (850)
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) GeneRIF 10912 |
| Urinary GADD45gamma expression is associated with progression of lgA nephropathy. Yu S., Cho J., Park I., Kim S.J., Kim H., Shin G.T.
Am. J. Nephrol. 30:135-139(2009) GeneRIF 10912 · Mapped (5)
urinary GADD45gamma expression is associated with progression of renal disease GeneRIF 10912 |
| Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis. Zhang W., Li T., Shao Y., Zhang C., Wu Q., Yang H., Zhang J., Guan M., Yu B., Wan J.
J. Cancer Res. Clin. Oncol. 136:1267-1273(2010) GeneRIF 10912 · Mapped (5)
Epigenetic regulation of GADD45G is associated with carcinogenesis in stomach colorectal and pancreateic cancers. GeneRIF 10912 |
| GADD45gamma: a new vitamin D-regulated gene that is antiproliferative in prostate cancer cells. Flores O., Burnstein K.L.
Endocrinology 151:4654-4664(2010) GeneRIF 10912 · Mapped (5)
The induction of GADD45gamma gene expression by 1 25-(OH)2D3 may mark therapeutic response in prostate cancer. GeneRIF 10912 |
| Expression of cell growth negative regulators MEG3 and GADD45gamma is lost in most sporadic human pituitary adenomas. Mezzomo L.C., Gonzales P.H., Pesce F.G., Kretzmann Filho N., Ferreira N.P., Oliveira M.C., Kohek M.B.
Pituitary 15:420-427(2012) GeneRIF 10912 · Mapped (5)
clinically non-functioning adenomas had a significant decrease (P<0.001) in the relative levels of GADD45c expression (13 of 14 adenomas or 92%) compared to functioning adenomas (11 of 24 or 46%) GeneRIF 10912 |
| Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-kappaB inhibitors in ovarian cancer therapy. Zerbini L.F., Tamura R.E., Correa R.G., Czibere A., Cordeiro J., Bhasin M., Simabuco F.M., Wang Y., Gu X., Li L. et al.
PLoS ONE 6:e24285-e24285(2011) GeneRIF 10912 · Mapped (11)
Data show that mda-7/IL-24 activation leads to upregulation of growth arrest and DNA damage inducible (GADD) 45 alpha and gamma and JNK activation. GeneRIF 10912 |
| Crystal structure of human Gadd45gamma reveals an active dimer. Zhang W., Fu S., Liu X., Zhao X., Zhang W., Peng W., Wu C., Li Y., Li X., Bartlam M. et al.
Protein Cell 2:814-826(2011) GeneRIF 10912 · Mapped (5)
These results reveal the mechanism of self-association by Gadd45 proteins and the importance of this self-association for their biological function GeneRIF 10912 |
| A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Goehler H., Lalowski M., Stelzl U., Waelter S., Stroedicke M., Worm U., Droege A., Lindenberg K.S., Knoblich M., Haenig C. et al.
Mol. Cell 15:853-865(2004) MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 MINT MINT-265043 · Mapped (69)
MINT-3979069. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with PIASy (uniprotkb:Q8N2W9) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979086. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with PLIP (uniprotkb:Q92993) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979103. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with PTN (uniprotkb:P21246) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979120. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with GDF9 (uniprotkb:O60383) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979137. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with PTPK (uniprotkb:Q15262) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979154. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with EF1A (uniprotkb:P68104) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979171. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with EF1G (uniprotkb:P26641) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979188. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with BAIP3 (uniprotkb:Q5T3J3) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979205. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with CGI.74 (uniprotkb:Q9Y383) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979222. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with CGI.125 (uniprotkb:Q9Y3C7) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979247. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with G45IP1 (uniprotkb:Q9H0V7) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979274. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with G45IP2 (uniprotkb:Q9NYA0) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979296. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with G45IP3 (uniprotkb:Q8NI70) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979313. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with HIP5 (uniprotkb:Q9PH0) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979330. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with HIP16 (uniprotkb:Q9BVJ6) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3979347. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with LUC7B1 (uniprotkb:Q9NQ29) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-3981610. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with HIP5 (uniprotkb:Q9PH0) by pull down (MI:0096). From mint MINT MINT-265043 MINT-3981674. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with PLIP (uniprotkb:Q92993) by pull down (MI:0096). From mint MINT MINT-265043 MINT-3981722. GADD45G (uniprotkb:O95257) physically interacts (MI:0915) with HIP16 (uniprotkb:Q9BVJ6) by pull down (MI:0096). From mint MINT MINT-265043 MINT-3981770. CGI-125 (uniprotkb:Q9Y3C7) physically interacts (MI:0915) with GADD45G (uniprotkb:O95257) by pull down (MI:0096). From mint MINT MINT-265043 |
| Towards a proteome-scale map of the human protein-protein interaction network. Rual J.F., Venkatesan K., Hao T., Hirozane-Kishikawa T., Dricot A., Li N., Berriz G.F., Gibbons F.D., Dreze M., Ayivi-Guedehoussou N. et al.
Nature 437:1173-1178(2005) MINT MINT-265043 MINT MINT-265043 · UniProtKB (1) · Mapped (1,321)
MINT-66050. RWDD2B (uniprotkb:P57060) physically interacts (MI:0915) with GADD45G (uniprotkb:O95257) by two hybrid (MI:0018). From mint MINT MINT-265043 MINT-66280. DKFZp686G1650 (uniprotkb:Q7Z3N9) physically interacts (MI:0915) with GADD45G (uniprotkb:O95257) by two hybrid (MI:0018). From mint MINT MINT-265043 |
