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21 results for uniprot:O88738Drop in citationmapping

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Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

Bartke T., Pohl C., Pyrowolakis G., Jentsch S.

Mol. Cell 14:801-811(2004) GeneRIF 12211 MGI 1276108 · Mapped (13)
BRUCE protects cells against apoptosis and functions as an inhibitor of apoptosis. GeneRIF 12211

An Apollon vista of death and destruction.

Martin S.J.

Nat. Cell Biol. 6:804-806(2004) GeneRIF 12211 · Mapped (8)
review of role of Apollonin in mechanisms of apoptosis and cell division GeneRIF 12211

BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival.

Lotz K., Pyrowolakis G., Jentsch S.

Mol. Cell. Biol. 24:9339-9350(2004) GeneRIF 12211 MGI 1276108 · Mapped (8)
BRUCE is broadly expressed in embryonic extraembryonic and adult mouse tissues this bifunctional protein might play a unique role in normal trophoblast differentiation and embryonic survival GeneRIF 12211

The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.

Ren J., Shi M., Liu R., Yang Q.H., Johnson T., Skarnes W.C., Du C.

Proc. Natl. Acad. Sci. U.S.A. 102:565-570(2005) GeneRIF 12211 MGI 1276108 · Mapped (37)
p53 is a downstream effector of Bruce and in response to loss of Bruce function p53 activates Pidd/caspase-2 and Bax/Bak leading to mitochondrial apoptosis GeneRIF 12211

Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE.

Jansen K.M., Pavlath G.K.

Cell Death Differ. 15:1619-1628(2008) GeneRIF 12211 · Mapped (8)
These results establish a previously unrecognized link between NFAT signaling and regulation of IAP expression and are the first to identify a signaling pathway that increases BRUCE expression. GeneRIF 12211

A human IAP-family gene, apollon, expressed in human brain cancer cells.

Chen Z., Naito M., Hori S., Mashima T., Yamori T., Tsuruo T.

Biochem. Biophys. Res. Commun. 264:847-854(1999) MGI 1276108 · UniProtKB (1) · Mapped (8)

Functional annotation of a full-length mouse cDNA collection.

Kawai J., Shinagawa A., Shibata K., Yoshino M., Itoh M., Ishii Y., Arakawa T., Hara A., Fukunishi Y., Konno H. et al.

Nature 409:685-690(2001) MGI 1276108 · UniProtKB (17,869) · Mapped (14,263)

Functional analysis of secreted and transmembrane proteins critical to mouse development.

Mitchell K.J., Pinson K.I., Kelly O.G., Brennan J., Zupicich J., Scherz P., Leighton P.A., Goodrich L.V., Lu X., Avery B.J. et al.

Nat. Genet. 28:241-249(2001) MGI 1276108 · Mapped (111)

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., Nikaido I., Osato N., Saito R., Suzuki H. et al.

Nature 420:563-573(2002) MGI 1276108 · UniProtKB (17,872) · Mapped (20,305)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.

Stryke D., Kawamoto M., Huang C.C., Johns S.J., King L.A., Harper C.A., Meng E.C., Lee R.E., Yee A., L'Italien L. et al.

Nucleic Acids Res. 31:278-281(2003) MGI 1276108 · Mapped (10,878)

Comparative analysis of apoptosis and inflammation genes of mice and humans.

Reed J.C., Doctor K., Rojas A., Zapata J.M., Stehlik C., Fiorentino L., Damiano J., Roth W., Matsuzawa S., Newman R. et al.

Genome Res. 13:1376-1388(2003) MGI 1276108 · Mapped (251)

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.

Hansen J., Floss T., Van Sloun P., Fuchtbauer E.M., Vauti F., Arnold H.H., Schnutgen F., Wurst W., von Melchner H., Ruiz P.

Proc. Natl. Acad. Sci. U.S.A. 100:9918-9922(2003) MGI 1276108 · Mapped (8,264)

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.

Zambrowicz B.P., Abuin A., Ramirez-Solis R., Richter L.J., Piggott J., BeltrandelRio H., Buxton E.C., Edwards J., Finch R.A., Friddle C.J. et al.

Proc. Natl. Acad. Sci. U.S.A. 100:14109-14114(2003) MGI 1276108 · Mapped (23,055)

Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function.

Hao Y., Sekine K., Kawabata A., Nakamura H., Ishioka T., Ohata H., Katayama R., Hashimoto C., Zhang X., Noda T. et al.

Nat. Cell Biol. 6:849-860(2004) MGI 1276108 · Mapped (25)

Mouse brain organization revealed through direct genome-scale TF expression analysis.

Gray P.A., Fu H., Luo P., Zhao Q., Yu J., Ferrari A., Tenzen T., Yuk D.I., Tsung E.F., Cai Z. et al.

Science 306:2255-2257(2004) MGI 1276108 · Mapped (3,874)

Tagging genes with cassette-exchange sites.

Cobellis G., Nicolaus G., Iovino M., Romito A., Marra E., Barbarisi M., Sardiello M., Di Giorgio F.P., Iovino N., Zollo M. et al.

Nucleic Acids Res. 33:e44-e44(2005) MGI 1276108 · Mapped (968)

Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.

Hitz C., Vogt-Weisenhorn D., Ruiz P., Wurst W., Floss T.

Genesis 42:91-103(2005) MGI 1276108 GeneRIF 12211 · Mapped (35)
Birc6 plays a role in cell division GeneRIF 12211

The transcriptional landscape of the mammalian genome.

Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C. et al.

Science 309:1559-1563(2005) MGI 1276108 · UniProtKB (27,424) · Mapped (12,732)

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

Pohl C., Jentsch S.

Cell 132:832-845(2008) MGI 1276108 · Mapped (14)

The inhibitors of apoptosis (IAPs) and their emerging role in cancer.

LaCasse E.C., Baird S., Korneluk R.G., MacKenzie A.E.

Oncogene 17:3247-3259(1998) MGI 1276108 · Mapped (50)

IAP family proteins--suppressors of apoptosis.

Deveraux Q.L., Reed J.C.

Genes Dev. 13:239-252(1999) MGI 1276108 · Mapped (18)

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