Jakobsson J., Ekstrom L., Inotsume N., Garle M., Lorentzon M., Ohlsson C., Roh H.K., Carlstrom K., Rane A.

J. Clin. Endocrinol. Metab. 91:687-693(2006) GAD 154993 GeneRIF 7367 · Mapped (1)
Associated with METABOLIC: testosterone; GAD 154993 Observational study of gene-disease association. (HuGE Navigator); The UGT2B17 polymorphism is strongly associated with the bimodal distribution of testosterone excretion and also with the large difference in testosterone excretion between Koreans and Swedes. GeneRIF 7367

Karypidis A.H., Olsson M., Andersson S.O., Rane A., Ekstrom L.

Pharmacogenomics J. 8:147-151(2008) GAD 154995 GeneRIF 7367 · Mapped (1)
Associated with CANCER: prostate cancer; GAD 154995 Observational study of gene-disease association. (HuGE Navigator); The UGT2B17 deletion polymorphism is associated with prostate cancer risk. GeneRIF 7367

Chouinard S., Pelletier G., Belanger A., Barbier O.

Endocr. Res. 30:717-725(2004) GeneRIF 7367 · Mapped (5)
In human prostate UGT2B15 and UGT2B17 genes have complementary roles and are expressed in cells where their specific substrates are synthesized. GeneRIF 7367

Lazarus P., Zheng Y., Aaron Runkle E., Muscat J.E., Wiener D.

Pharmacogenet. Genomics 15:769-778(2005) GeneRIF 7367 · Mapped (1)
UGT2B17 deletion polymorphism is associated with a reduced rate of NNAL detoxification in vivo and may increase individual susceptibility to tobacco-related cancers. GeneRIF 7367

Park J., Chen L., Ratnashinge L., Sellers T.A., Tanner J.P., Lee J.H., Dossett N., Lang N., Kadlubar F.F., Ambrosone C.B. et al.

Cancer Epidemiol. Biomarkers Prev. 15:1473-1478(2006) GeneRIF 7367 GAD 154994 · Mapped (1)
Associated with CANCER: prostate cancer; GAD 154994 Deletion polymorphism of UDP-glucuronosyltransferase 2B17 is associated with prostate cancer; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

Gallagher C.J., Muscat J.E., Hicks A.N., Zheng Y., Dyer A.M., Chase G.A., Richie J., Lazarus P.

Cancer Epidemiol. Biomarkers Prev. 16:823-828(2007) GeneRIF 7367 · Mapped (1)
association of the UGT2B17 deletion with increased lung adenocarcinoma in women is consistent with its association with decreased 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation rates in women; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

Swanson C., Mellstrom D., Lorentzon M., Vandenput L., Jakobsson J., Rane A., Karlsson M., Ljunggren O., Smith U., Eriksson A.L. et al.

J. Clin. Endocrinol. Metab. 92:4878-4882(2007) GeneRIF 7367 · Mapped (5)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

Park J.Y., Tanner J.P., Sellers T.A., Huang Y., Stevens C.K., Dossett N., Shankar R.A., Zachariah B., Heysek R., Pow-Sang J.

Urology 70:374-379(2007) GeneRIF 7367 · Mapped (3)
results suggest that the HSD3B1 N367T and UGT2B17 null polymorphisms may modify the risk of prostate cancer particularly among men with a family history of the disease; Observational study of gene-disease association gene-gene interaction and gene-environment interaction. (HuGE Navigator) GeneRIF 7367

Chouinard S., Barbier O., Belanger A.

J. Biol. Chem. 282:33466-33474(2007) GeneRIF 7367 · Mapped (5)
UGT2B15 and -B17 are critical enzymes for the local inactivation of androgens and that glucuronidation is a major determinant of androgen action in prostate cells GeneRIF 7367

Gallagher C.J., Kadlubar F.F., Muscat J.E., Ambrosone C.B., Lang N.P., Lazarus P.

Cancer Detect. Prev. 31:310-315(2007) GeneRIF 7367 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator); These findings show that the UGT2B17 deletion polymorphism is not associated with prostate cancer risk in Caucasians. GeneRIF 7367

Kaeding J., Bouchaert E., Belanger J., Caron P., Chouinard S., Verreault M., Larouche O., Pelletier G., Staels B., Belanger A. et al.

Biochem. J. 410:245-253(2008) GeneRIF 7367 · Mapped (12)
Androsterone reduces the glucuronidation of androgens catalysed by UGT2B15 and UGT2B17 in a prostate tumor cell line. GeneRIF 7367

Heinold A., Opelz G., Scherer S., Ruhenstroth A., Laux G., Doehler B., Tran T.H.

Am. J. Transplant. 8:95-102(2008) GeneRIF 7367 · Mapped (1,759)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

Olsson M., Lindstrom S., Haggkvist B., Adami H.O., Balter K., Stattin P., Ask B., Rane A., Ekstrom L., Gronberg H.

Prostate 68:571-575(2008) GeneRIF 7367 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator); The UGT2B17 deletion polymorphism does not play a major role in prostate cancer susceptibility as previously indicated. GeneRIF 7367

Kaeding J., Belanger J., Caron P., Verreault M., Belanger A., Barbier O.

Mol. Cancer Ther. 7:380-390(2008) GeneRIF 7367 · Mapped (22)
Vitamin D receptor activator calcitriol as a negative regulator of the UGT2B15- and UGT2B17-dependent inactivation of androgens in prostate cancer LNCaP cells. GeneRIF 7367

Bao B.Y., Chuang B.F., Wang Q., Sartor O., Balk S.P., Brown M., Kantoff P.W., Lee G.S.

Prostate 68:839-848(2008) GeneRIF 7367 · Mapped (16)
UGT2B17 ia a primary androgen-regulated genes and androgen receptor is required for basal expression and androgen-regulated expression. GeneRIF 7367

Schulze J.J., Lundmark J., Garle M., Skilving I., Ekstrom L., Rane A.

J. Clin. Endocrinol. Metab. 93:2500-2506(2008) GeneRIF 7367 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

Xue Y., Sun D., Daly A., Yang F., Zhou X., Zhao M., Huang N., Zerjal T., Lee C., Carter N.P. et al.

Am. J. Hum. Genet. 83:337-346(2008) GeneRIF 7367 · Mapped (1)
Diversity was unusually high with evidence of balancing selection in Europe. In contrast diversity was low in East Asia where a single haplotype predominated suggesting positive selection for the deletion in this part of the world GeneRIF 7367

Schulze J.J., Lundmark J., Garle M., Ekstrom L., Sottas P.E., Rane A.

Steroids 74:365-368(2009) GeneRIF 7367 · Mapped (1)
Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 7367

Juul A., Sorensen K., Aksglaede L., Garn I., Rajpert-De Meyts E., Hullstein I., Hemmersbach P., Ottesen A.M.

J. Clin. Endocrinol. Metab. 94:1005-1011(2009) GeneRIF 7367 · Mapped (1)
In pubertal boys a common homozygous deletion in the UGT2B17 gene strongly affected urinary excretion pattern of androgen metabolites but did not influence circulating androgen levels; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

Strahm E., Sottas P.E., Schweizer C., Saugy M., Dvorak J., Saudan C.

Br J Sports Med 43:1126-1130(2009) GeneRIF 7367 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

Balliet R.M., Chen G., Gallagher C.J., Dellinger R.W., Sun D., Lazarus P.

Cancer Res. 69:2981-2989(2009) GeneRIF 7367 · Mapped (1)
Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 7367

Menard V., Eap O., Harvey M., Guillemette C., Levesque E.

Hum. Mutat. 30:1310-1319(2009) GeneRIF 7367 · Mapped (6)
Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 GeneRIF 7367

Ahn J., Schumacher F.R., Berndt S.I., Pfeiffer R., Albanes D., Andriole G.L., Ardanaz E., Boeing H., Bueno-de-Mesquita B., Chanock S.J. et al.

Hum. Mol. Genet. 18:3749-3757(2009) GeneRIF 7367 · Mapped (211)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

McCarroll S.A., Bradner J.E., Turpeinen H., Volin L., Martin P.J., Chilewski S.D., Antin J.H., Lee S.J., Ruutu T., Storer B. et al.

Nat. Genet. 41:1341-1344(2009) GeneRIF 7367 · Mapped (1)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367

Setlur S.R., Chen C.X., Hossain R.R., Ha J.S., Van Doren V.E., Stenzel B., Steiner E., Oldridge D., Kitabayashi N., Banerjee S. et al.

Cancer Epidemiol. Biomarkers Prev. 19:229-239(2010) GeneRIF 7367 · Mapped (15)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7367