uniprot:O60770 in citationmapping

1 - 25 of 29 results for uniprot:O60770 in citationmapping

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly. Alvarez M., Estivill X., de la Luna S. J. Cell. Sci. 116:3099-3107(2003) GeneRIF 1859 · Mapped (6) DYRK1A protein kinase may play a role in regulating the biogenesis of the splicing speckle compartment GeneRIF 1859
Overexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosome. Funakoshi E., Hori T., Haraguchi T., Hiraoka Y., Kudoh J., Shimizu N., Ito F. BMC Cell Biol. 4:12-12(2003) GeneRIF 1859 · Mapped (6) Overexpression of DYRK1A induces multinucleation through overduplication of the centrosome during interphase. GeneRIF 1859
Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors. de Graaf K., Hekerman P., Spelten O., Herrmann A., Packman L.C., Bussow K., Muller-Newen G., Becker W. J. Biol. Chem. 279:4612-4624(2004) GeneRIF 1859 · Mapped (12) characterize cyclin L2 as a highly mobile component of nuclear speckles and suggest that DYRK1A may regulate splicing by phosphorylation of cyclin L2 GeneRIF 1859
The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications. Hammerle B., Elizalde C., Galceran J., Becker W., Tejedor F.J. J. Neural Transm. Suppl. 2003:129-137(2003) GeneRIF 1859 · Mapped (6) In this review experimental evidence is compiled and discussed which supports the involvement of MNB/DYRK1A in several neuropathologies and cognitive deficits of Down syndrome. GeneRIF 1859
The MNB/DYRK1A protein kinase: genetic and biochemical properties. Galceran J., de Graaf K., Tejedor F.J., Becker W. J. Neural Transm. Suppl. 2003:139-148(2003) GeneRIF 1859 · Mapped (6) Although the function of MNB/DYRK1A in intracellular signalling and regulation of cell function is still poorly defined current evidence in this review suggests that MNB/DYRK1A kinase may play a role in the regulation of gene expression. GeneRIF 1859
Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain. Wegiel J., Kuchna I., Nowicki K., Frackowiak J., Dowjat K., Silverman W.P., Reisberg B., DeLeon M., Wisniewski T., Adayev T. et al. Brain Res. 1010:69-80(2004) GeneRIF 1859 · Mapped (6) Neurons were the only cells showing the presence of Mnb kinase in both cell nucleus and cytoplasm. Nuclear localization supports the concept that Mnb may be involved in control of gene expression. GeneRIF 1859
Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein. Bescond M., Rahmani Z. Int. J. Biochem. Cell Biol. 37:775-783(2005) GeneRIF 1859 · Mapped (8) encodes a serine-threonine kinase but despite its potential involvement in the neurobiological alterations associated with Down syndrome GeneRIF 1859
DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Kelly P.A., Rahmani Z. Mol. Biol. Cell 16:3562-3573(2005) GeneRIF 1859 · Mapped (9) DYRK1A may play a critical role in Ras-dependent transducing signals that are required for promoting or maintaining neuronal differentiation GeneRIF 1859
Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Ferrer I., Barrachina M., Puig B., Martinez de Lagran M., Marti E., Avila J., Dierssen M. Neurobiol. Dis. 20:392-400(2005) GeneRIF 1859 · Mapped (6) The present observations indicate modifications in the expression of constitutive Dyrk1A in the cytoplasm and nuclei of neurons in various neurodegenerative diseases associated with tau phosphorylation. GeneRIF 1859
Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome. Murakami N., Xie W., Lu R.C., Chen-Hwang M.C., Wieraszko A., Hwang Y.W. J. Biol. Chem. 281:23712-23724(2006) GeneRIF 1859 · Mapped (20) Mnb/Dyrk1A is responsible for in vivo phosphorylation of amphiphysin I at serine-293. GeneRIF 1859
Cooperation to amplify gene-dosage-imbalance effects. de la Luna S., Estivill X. Trends Mol Med 12:451-454(2006) GeneRIF 1859 · Mapped (11) There is now compelling evidence that the protein products of two genes on chromosome 21 Down syndrome candidate region 1 (DSCR1) and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) interact functionally. GeneRIF 1859
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Kimura R., Kamino K., Yamamoto M., Nuripa A., Kida T., Kazui H., Hashimoto R., Tanaka T., Kudo T., Yamagata H. et al. Hum. Mol. Genet. 16:15-23(2007) GeneRIF 1859 · Mapped (11) Our result indicates that DYRK1A could be a key molecule bridging between beta-amyloid production and tau phosphorylation in AD. GeneRIF 1859
Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome. Dowjat W.K., Adayev T., Kuchna I., Nowicki K., Palminiello S., Hwang Y.W., Wegiel J. Neurosci. Lett. 413:77-81(2007) GeneRIF 1859 · Mapped (6) in DS subjects the brain levels of DYRK1A protein were increased approximately 1.5-fold indicating that this protein is overexpressed in gene dosage-dependent manner. GeneRIF 1859
DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding. Alvarez M., Altafaj X., Aranda S., de la Luna S. Mol. Biol. Cell 18:1167-1178(2007) GeneRIF 1859 · Mapped (12) DYRK1A autophosphorylates via an intramolecular mechanism on Ser-520 this phosphorylation allows the binding of 14-3-3beta which in turn stimulates the catalytic activity of DYRK1A GeneRIF 1859
Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis. Chang H.S., Lin C.H., Yang C.H., Yen M.S., Lai C.R., Chen Y.R., Liang Y.J., Yu W.C. Int. J. Cancer 120:2377-2385(2007) GeneRIF 1859 · Mapped (6) raised Dyrk1a in HPV16 immortalized keratinocytes and cervical lesions may serve as a candidate antiapoptotic factor in the FKHR regulated pathway and initiate immortalization and tumorigenesis gradually GeneRIF 1859
Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro. Adayev T., Chen-Hwang M.C., Murakami N., Lee E., Bolton D.C., Hwang Y.W. Biochemistry 46:7614-7624(2007) GeneRIF 1859 · Mapped (6) DYRK does not require tyrosine phosphorylation for activity in vitro. GeneRIF 1859
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease. Ryoo S.R., Jeong H.K., Radnaabazar C., Yoo J.J., Cho H.J., Lee H.W., Kim I.S., Cheon Y.H., Ahn Y.S., Chung S.H. et al. J. Biol. Chem. 282:34850-34857(2007) GeneRIF 1859 · Mapped (13) DYRK1A has a role in the hyperphosphorylation of Tau and an extra copy of the DYRK1A gene contributes to the early onset of Alzheimer disease GeneRIF 1859
Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease. Ryoo S.R., Cho H.J., Lee H.W., Jeong H.K., Radnaabazar C., Kim Y.S., Kim M.J., Son M.Y., Seo H., Chung S.H. et al. J. Neurochem. 104:1333-1344(2008) GeneRIF 1859 · Mapped (6) Over-expression of DYRK1A in Down syndrome may play a role in accelerating Alzheimer's disease pathogenesis through phosphorylation of beta-amyloid precursor protein (APP). GeneRIF 1859
Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21. Sebrie C., Chabert C., Ledru A., Guedj F., Po C., Smith D.J., Rubin E., Rivals I., Beloeil J.C., Gillet B. et al. Anat Rec (Hoboken) 291:254-262(2008) GeneRIF 1859 · Mapped (6) Use DYRK1A transgenic mice as a model for partial trisomy 21 and determine changes in brain volume. GeneRIF 1859
Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1. Maenz B., Hekerman P., Vela E.M., Galceran J., Becker W. BMC Mol. Biol. 9:30-30(2008) GeneRIF 1859 · Mapped (8) The regulatory effect of E2F1 suggests that DYRK1A may play a role in cell cycle regulation or apoptosis. GeneRIF 1859
Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly. Moller R.S., Kubart S., Hoeltzenbein M., Heye B., Vogel I., Hansen C.P., Menzel C., Ullmann R., Tommerup N., Ropers H.H. et al. Am. J. Hum. Genet. 82:1165-1170(2008) GeneRIF 1859 · Mapped (6) truncating mutations of DYRK1A result in a clinical phenotype including microcephaly. GeneRIF 1859
DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residues. Liang Y.J., Chang H.S., Wang C.Y., Yu W.C. Int. J. Biochem. Cell Biol. 40:2431-2441(2008) GeneRIF 1859 · Mapped (6) Results suggest that DYRK1A increases the transforming potential of HPV16-infected cells because of the greater stability of HPV16E7. GeneRIF 1859
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. Liu F., Liang Z., Wegiel J., Hwang Y.W., Iqbal K., Grundke-Iqbal I., Ramakrishna N., Gong C.X. FASEB J. 22:3224-3233(2008) GeneRIF 1859 · Mapped (6) Dyrk1A-induced tau phosphorylation inhibited its biological activity & promoted self-aggregation. findings suggest novel mechanism by which overexpression of Dyrk1A in Down syndrome brain causes neurofibrillary degeneration via hyperphosphorylation. GeneRIF 1859
The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome. Wegiel J., Dowjat K., Kaczmarski W., Kuchna I., Nowicki K., Frackowiak J., Mazur Kolecka B., Wegiel J., Silverman W.P., Reisberg B. et al. Acta Neuropathol. 116:391-407(2008) GeneRIF 1859 · Mapped (6) DYRK1A is involved in nerve degeneration and that overexpression of this kinase may contribute to the early onset of these pathologies in Down syndrome. GeneRIF 1859
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Canzonetta C., Mulligan C., Deutsch S., Ruf S., O'Doherty A., Lyle R., Borel C., Lin-Marq N., Delom F., Groet J. et al. Am. J. Hum. Genet. 83:388-400(2008) GeneRIF 1859 · Mapped (20) DYRK1A-mediated deregulation of REST is a very early pathological consequence of trisomy 21 with potential to disturb the development of all embryonic lineages. GeneRIF 1859