Sanchez E., Orozco G., Lopez-Nevot M.A., Jimenez-Alonso J., Martin J.

Tissue Antigens 63:54-57(2004) GAD 136304 GeneRIF 7097 GAD 136295 · Mapped (3)
Not Associated with IMMUNE: lupus erythematosus; rheumatoid arthritis; GAD 136304 Not Associated with IMMUNE: systemic lupus erythematosus; GAD 136295 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7097

Folwaczny M., Glas J., Torok H.P., Limbersky O., Folwaczny C.

Clin. Exp. Immunol. 135:330-335(2004) GAD 136307 GeneRIF 7097 GAD 136293 · Mapped (3)
Not Associated with IMMUNE: periodontal disease; GAD 136307 GAD 136293 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7097

Ogus A.C., Yoldas B., Ozdemir T., Uguz A., Olcen S., Keser I., Coskun M., Cilli A., Yegin O.

Eur. Respir. J. 23:219-223(2004) GAD 136297 GeneRIF 7097 · Mapped (2)
Associated with INFECTION: tuberculosis; GAD 136297 Observational study of gene-disease association. (HuGE Navigator); The present data suggest that the arginine to glutamine substitution at residue 753 polymorphism of the Toll-like receptor 2 gene influences the risk of developing tuberculosis. GeneRIF 7097

Noguchi E., Nishimura F., Fukai H., Kim J., Ichikawa K., Shibasaki M., Arinami T.

Clin. Exp. Allergy 34:177-183(2004) GAD 136305 GeneRIF 7097 · Mapped (16)
Not Associated with IMMUNE: asthma; GAD 136305 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7097

Eder W., Klimecki W., Yu L., von Mutius E., Riedler J., Braun-Fahrlander C., Nowak D., Martinez F.D.

J. Allergy Clin. Immunol. 113:482-488(2004) GAD 136294 GAD 136308 GeneRIF 7097 · Mapped (2)
Associated with IMMUNE: Asthma; GAD 136294 Associated with IMMUNE: asthma; allergic rhinitis; atopic dermatitis; GAD 136308 Observational study of gene-disease association. (HuGE Navigator); genetic variation in TLR2 is a major determinant of the susceptibility to asthma and allergies in children of farmers GeneRIF 7097

Ben-Ali M., Barbouche M.R., Bousnina S., Chabbou A., Dellagi K.

Clin. Diagn. Lab. Immunol. 11:625-626(2004) GAD 136298 GeneRIF 7097 · Mapped (2)
Associated with INFECTION: tuberculosis; GAD 136298 Observational study of gene-disease association. (HuGE Navigator); The frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). GeneRIF 7097

Moore C.E., Segal S., Berendt A.R., Hill A.V., Day N.P.

Clin. Diagn. Lab. Immunol. 11:1194-1197(2004) GAD 136299 GeneRIF 7097 · Mapped (2)
Not Associated with INFECTION: Staphylococcus aureus infection; GAD 136299 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7097

Park Y., Park S., Yoo E., Kim D., Shin H.

Ann. N. Y. Acad. Sci. 1037:170-174(2004) GAD 136300 GeneRIF 7097 · Mapped (4)
Associated with IMMUNE: diabetes, type 1; GAD 136300 Observational study of gene-disease association. (HuGE Navigator); TLR2 polymorphisms are associated with diabetes mellitus type 1 (T1DM) and distribution differences between T1DM vs controls were not influenced by the HLA genes. GeneRIF 7097

Yim J.J., Lee H.W., Lee H.S., Kim Y.W., Han S.K., Shim Y.S., Holland S.M.

Genes Immun. 7:150-155(2006) GAD 154377 GeneRIF 7097 · Mapped (2)
Associated with INFECTION: tuberculosis; GAD 154377 The development of tuberculosis in Koreans is associated with shorter guanine-thymine repeats in intron II of the TLR2 gene; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7097

Boraska Jelavic T., Barisic M., Drmic Hofman I., Boraska V., Vrdoljak E., Peruzovic M., Hozo I., Puljiz Z., Terzic J.

Clin. Genet. 70:156-160(2006) GAD 154381 GeneRIF 7097 · Mapped (3)
Associated with CANCER: colorectal cancer; GAD 154381 Observational study of gene-disease association. (HuGE Navigator); we report an association of microsatelite GT polymorphisms of TLR2 gene and Asp299Gly polymorphism of the TLR4 gene with sporadic colorectal cancer among Croatians. GeneRIF 7097

Santin I., Bilbao J.R., de Nanclares G.P., Calvo B., Castano L.

Ann. N. Y. Acad. Sci. 1079:268-272(2006) GAD 154387 GeneRIF 7097 · Mapped (5)
Not Associated with IMMUNE: diabetes, type 1; GAD 154387 There is no association of TLR2 polymorphism with diabetes mellitus type 1 in the Basque population; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7097

Thuong N.T., Hawn T.R., Thwaites G.E., Chau T.T., Lan N.T., Quy H.T., Hieu N.T., Aderem A., Hien T.T., Farrar J.J. et al.

Genes Immun. 8:422-428(2007) GAD 154398 GeneRIF 7097 · Mapped (2)
Associated with INFECTION: tuberculosis meningitis; GAD 154398 Observational study of gene-disease association. (HuGE Navigator); study demonstrates a strong association of TLR2 single nucleotide polymorphism T597C with the development of Tuberculous meningitis and miliary TB and indicate that TLR2 influences the dissemination of M. tuberculosis GeneRIF 7097

Berdeli A., Emingil G., Han Saygan B., Gurkan A., Atilla G., Kose T., Baylas H.

J. Clin. Periodontol. 34:551-557(2007) GAD 154400 GeneRIF 7097 · Mapped (3)
Not Associated with IMMUNE: periodontitis; GAD 154400 Observational study of gene-disease association. (HuGE Navigator); TLR2 gene polymorphisms are not associated with susceptibility to chronic periodontitis in Turkish patients. GeneRIF 7097

Veltkamp M., Wijnen P.A., van Moorsel C.H., Rijkers G.T., Ruven H.J., Heron M., Bekers O., Claessen A.M., Drent M., van den Bosch J.M. et al.

Clin. Exp. Immunol. 149:453-462(2007) GAD 154401 GeneRIF 7097 · Mapped (2)
Associated with IMMUNE: sarcoidosis; GAD 154401 data show that polymorphisms in TLR-2 might be important in a small group of sarcoidosis patients and that their functional consequences explain partly some of the variance in cytokine pattern observed in different clinical phenotypes of this disease; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7097

Wang S.S., Bratti M.C., Rodriguez A.C., Herrero R., Burk R.D., Porras C., Gonzalez P., Sherman M.E., Wacholder S., Lan Z.E. et al.

J. Infect. Dis. 199:20-30(2009) GAD 560306 GeneRIF 7097 · Mapped (330)
Associated with CANCER: cervical intraepithelial neoplasia grade 3; GAD 560306 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 7097

Takagi Y., Masamune A., Kume K., Satoh A., Kikuta K., Watanabe T., Satoh K., Hirota M., Shimosegawa T.

Hum. Immunol. 0:0-0(2009) GAD 560284 · Mapped (3)
Associated with OTHER: acute pancreatitis; GAD 560284

Lorenz E., Mira J.P., Cornish K.L., Arbour N.C., Schwartz D.A.

Infect. Immun. 68:6398-6401(2000) GeneRIF 7097 GAD 136292 GAD 136296 · Mapped (2)
Associated with IMMUNE: atherosclerosis, coronary; GAD 136296 Associated with IMMUNE: staphylococcal infection; GAD 136292 Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 7097

Re F., Strominger J.L.

J. Biol. Chem. 276:37692-37699(2001) GeneRIF 7097 · Mapped (2)
TLR2 stimulation resulted in the release of the IL-12 inhibitory p40 homodimer producing conditions that are predicted to favor Th2 development also resulted in preferential induction of IL-8 and p19/IL-23. GeneRIF 7097

Murakami S., Iwaki D., Mitsuzawa H., Sano H., Takahashi H., Voelker D.R., Akino T., Kuroki Y.

J. Biol. Chem. 277:6830-6837(2002) GeneRIF 7097 · Mapped (16)
These results indicate that the direct interaction of SP-A with TLR2 alters PGN-induced cell signaling GeneRIF 7097

Asea A., Rehli M., Kabingu E., Boch J.A., Bare O., Auron P.E., Stevenson M.A., Calderwood S.K.

J. Biol. Chem. 277:15028-15034(2002) GeneRIF 7097 · Mapped (2)
identification of role in novel signal transduction pathway utilized by exracellular HSP70 GeneRIF 7097

Vabulas R.M., Ahmad-Nejad P., Ghose S., Kirschning C.J., Issels R.D., Wagner H.

J. Biol. Chem. 277:15107-15112(2002) GeneRIF 7097 · Mapped (2)
stimulation of signal pathway by HSP70 GeneRIF 7097

Shuto T., Imasato A., Jono H., Sakai A., Xu H., Watanabe T., Rixter D.D., Kai H., Andalibi A., Linthicum F. et al.

J. Biol. Chem. 277:17263-17270(2002) GeneRIF 7097 · Mapped (7)
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. GeneRIF 7097

Vasselon T., Hanlon W.A., Wright S.D., Detmers P.A.

J. Leukoc. Biol. 71:503-510(2002) GeneRIF 7097 · Mapped (2)
TLR2 initiated the signaling pathway for p38 in response to bacterial products /LPS/ GeneRIF 7097

Carl V.S., Brown-Steinke K., Nicklin M.J., Smith M.F. Jr.

J. Biol. Chem. 277:17448-17456(2002) GeneRIF 7097 · Mapped (2)
signaling events by TLR2 and TLR4 agonists are similar but there are distinct differences in the responses elicited by two bacterial products GeneRIF 7097

Netea M.G., Kullberg B.J., Galama J.M., Stalenhoef A.F., Dinarello C.A., Van der Meer J.W.

Eur. J. Immunol. 32:1188-1195(2002) GeneRIF 7097 · Mapped (8)
Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways. GeneRIF 7097