| Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression. Sugden M.C., Kraus A., Harris R.A., Holness M.J.
Biochem. J. 346:651-657(2000) RGD 69061 · Mapped (2) |
| Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism. Holness M.J., Smith N.D., Bulmer K., Hopkins T., Gibbons G.F., Sugden M.C.
Biochem. J. 364:687-694(2002) RGD 69061 · Mapped (2) |
| Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha). Holness M.J., Bulmer K., Gibbons G.F., Sugden M.C.
Biochem. J. 366:839-846(2002) RGD 69061 · Mapped (1) |
| Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone. Holness M.J., Bulmer K., Smith N.D., Sugden M.C.
Biochem. J. 369:687-695(2003) RGD 69061 · Mapped (2) |
| Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Lee F.N., Zhang L., Zheng D., Choi W.S., Youn J.H.
Am. J. Physiol. Endocrinol. Metab. 287:E69-74(2004) RGD 69061 · Mapped (1) |
| High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek A.E., Gullings-Handley J., Yu J., Carlos D.C., Orlebeke K., Nie J., Eckert J., Lemke A., Andrae J.W., Bromberg S. et al.
Genome Res. 14:750-757(2004) RGD 69061 · Mapped (388) |
| Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima Fatty rat both before and after the onset of diabetes mellitus. Bajotto G., Murakami T., Nagasaki M., Tamura T., Tamura N., Harris R.A., Shimomura Y., Sato Y.
Life Sci. 75:2117-2130(2004) RGD 69061 · Mapped (2) |
| Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor. Savkur R.S., Bramlett K.S., Michael L.F., Burris T.P.
Biochem. Biophys. Res. Commun. 329:391-396(2005) RGD 69061 · Mapped (11) |
| Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator. Ma K., Zhang Y., Elam M.B., Cook G.A., Park E.A.
J. Biol. Chem. 280:29525-29532(2005) RGD 69061 · Mapped (2) |
| Increased expression of hepatic pyruvate dehydrogenase kinases 2 and 4 in young and middle-aged Otsuka Long-Evans Tokushima Fatty rats: induction by elevated levels of free fatty acids. Bajotto G., Murakami T., Nagasaki M., Qin B., Matsuo Y., Maeda K., Ohashi M., Oshida Y., Sato Y., Shimomura Y.
Metab. Clin. Exp. 55:317-323(2006) RGD 69061 · Mapped (2) |
| Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Kim Y.I., Lee F.N., Choi W.S., Lee S., Youn J.H.
Diabetes 55:2311-2317(2006) RGD 69061 · Mapped (1) |
| Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression. Kusuhara K., Madsen K., Jensen L., Hellsten Y., Pilegaard H.
Biol. Chem. 388:481-488(2007) RGD 69061 · Mapped (3) |
| Dysregulated pyruvate dehydrogenase complex in Zucker diabetic fatty rats. Schummer C.M., Werner U., Tennagels N., Schmoll D., Haschke G., Juretschke H.P., Patel M.S., Gerl M., Kramer W., Herling A.W.
Am. J. Physiol. Endocrinol. Metab. 294:E88-96(2008) RGD 69061 · Mapped (1) |
| Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. Zhao G., Jeoung N.H., Burgess S.C., Rosaaen-Stowe K.A., Inagaki T., Latif S., Shelton J.M., McAnally J., Bassel-Duby R., Harris R.A. et al.
Am. J. Physiol. Heart Circ. Physiol. 294:H936-43(2008) RGD 69061 · Mapped (1) |
| Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue. Cadoudal T., Distel E., Durant S., Fouque F., Blouin J.M., Collinet M., Bortoli S., Forest C., Benelli C.
Diabetes 57:2272-2279(2008) RGD 69061 · Mapped (7) |
| Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids. Houten S.M., Chegary M., Te Brinke H., Wijnen W.J., Glatz J.F., Luiken J.J., Wijburg F.A., Wanders R.J.
Cell. Mol. Life Sci. 66:1283-1294(2009) RGD 69061 · Mapped (2) |
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