Fujita N., Sato S., Ishida A., Tsuruo T.

J. Biol. Chem. 277:10346-10353(2002) GeneRIF 5170 · Mapped (13)
association of PDK1 with Hsp90 regulates its stability solubility and signaling GeneRIF 5170

Wick M.J., Wick K.R., Chen H., He H., Dong L.Q., Quon M.J., Liu F.

J. Biol. Chem. 277:16632-16638(2002) GeneRIF 5170 · Mapped (12)
Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells GeneRIF 5170

Egawa K., Maegawa H., Shi K., Nakamura T., Obata T., Yoshizaki T., Morino K., Shimizu S., Nishio Y., Suzuki E. et al.

J. Biol. Chem. 277:38863-38869(2002) GeneRIF 5170 · Mapped (5)
Data show that the translocation of 3-phosphoinositide-dependent protein kinase-1 from cytosol to the plasma membrane is critical for Akt and glycogen synthase kinase-3 activation. GeneRIF 5170

Frodin M., Antal T.L., Dummler B.A., Jensen C.J., Deak M., Gammeltoft S., Biondi R.M.

EMBO J. 21:5396-5407(2002) GeneRIF 5170 · Mapped (5)
In some growth factor-activated AGC protein kinases phosphorylation of the hydrophobic motif creates a specific docking site that recruits and activates PDK1 which then phosphorylates the activation loop. GeneRIF 5170

Scott M.T., Ingram A., Ball K.L.

EMBO J. 21:6771-6780(2002) GeneRIF 5170 · Mapped (5)
PDK1 has a role in activating atypical PKC and regulating the degradation of p21(WAF1) GeneRIF 5170

Collins B.J., Deak M., Arthur J.S., Armit L.J., Alessi D.R.

EMBO J. 22:4202-4211(2003) GeneRIF 5170 · Mapped (17)
The in vivo role of the PIF-binding site of PDK1 is defined by knock-in mutation. GeneRIF 5170

Weber D.S., Taniyama Y., Rocic P., Seshiah P.N., Dechert M.A., Gerthoffer W.T., Griendling K.K.

Circ. Res. 94:1219-1226(2004) GeneRIF 5170 · Mapped (10)
Src- & ROS-dependent PDK1 activation leads to site-specific PAK1 phosphorylation. This is critically important for PDGF-induced VSMC migration a process integral to the vascular response to injury that leads to vessel occlusion & plaque formation. GeneRIF 5170

Komander D., Kular G., Deak M., Alessi D.R., van Aalten D.M.

J. Biol. Chem. 280:18797-18802(2005) GeneRIF 5170 PDB 2BIY · Mapped (5)
the integrity of the alpha C-helix and HM-pocket in PDK1 is not regulated by T-loop phosphorylation GeneRIF 5170

Lee K.Y., D'Acquisto F., Hayden M.S., Shim J.H., Ghosh S.

Science 308:114-118(2005) GeneRIF 5170 · Mapped (6)
PDK1 plays a critical role by nucleating the TCR-induced NF-kappaB activation pathway in T cells GeneRIF 5170

Lin H.J., Hsieh F.C., Song H., Lin J.

Br. J. Cancer 93:1372-1381(2005) GeneRIF 5170 · Mapped (5)
PDK-1 may promote oncogenesis in part through the activation of AKT and p7 GeneRIF 5170

Xie Z., Yuan H., Yin Y., Zeng X., Bai R., Glazer R.I.

BMC Cancer 6:77-77(2006) GeneRIF 5170 · Mapped (28)
PDK1 mediates mammary epithelial cell growth and invasion in part by MT1-MMP induction which in turn activates MMP-2 and modulates the ECM proteins decorin and collagen GeneRIF 5170

Gao X., Harris T.K.

J. Biol. Chem. 281:21670-21681(2006) GeneRIF 5170 · Mapped (5)
PDK1-catalyzed trans-phosphorylation of PDK1-Tide approximates a Rapid Equilibrium Random Bi Bi system where motions in the central ternary complex are largely rate-determining GeneRIF 5170

Parhar K., Eivemark S., Assi K., Gomez-Munoz A., Yee A., Salh B.

Mol. Cell. Biochem. 300:113-127(2007) GeneRIF 5170 · Mapped (16)
These data reveals for the first time that PDK1 and PKB may differentially activate NF-kappaB and that TPCK may subserve a useful anti-inflammatory function by inhibiting IKKbeta. GeneRIF 5170

Pearn L., Fisher J., Burnett A.K., Darley R.L.

Blood 109:4461-4469(2007) GeneRIF 5170 · Mapped (17)
Ras is able to promote monocyte lineage selection via PKC and PDK1. GeneRIF 5170

Freeley M., Park J., Yang K.J., Wange R.L., Volkov Y., Kelleher D., Long A.

Cell. Signal. 19:2444-2457(2007) GeneRIF 5170 · Mapped (8)
Loss of PTEN expression in Jurkat T cells does not impact on the PDK-1/PKC pathway and that only a subset of kinases such as PKB/Akt are perturbed as a consequence PTEN loss. GeneRIF 5170

Hayashi T., Mo J.H., Gong X., Rossetto C., Jang A., Beck L., Elliott G.I., Kufareva I., Abagyan R., Broide D.H. et al.

Proc. Natl. Acad. Sci. U.S.A. 104:18619-18624(2007) GeneRIF 5170 · Mapped (5)
3-Hydroxyanthranilic acid inhibits NF-kappaB activation upon T cell antigen receptor engagement by specifically targeting PDK1 GeneRIF 5170

Pinner S., Sahai E.

Nat. Cell Biol. 10:127-137(2008) GeneRIF 5170 · Mapped (15)
There is a non-catalytic role for PDK1 in regulating cortical acto-myosin and cell motility. GeneRIF 5170

Vejux A., Guyot S., Montange T., Riedinger J.M., Kahn E., Lizard G.

J. Nutr. Biochem. 20:45-61(2009) GeneRIF 5170 · Mapped (13)
7-ketocholesterol-induced apoptosis has a role in phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway GeneRIF 5170

Lu Y., Dolle M.E., Imholz S., van 't Slot R., Verschuren W.M., Wijmenga C., Feskens E.J., Boer J.M.

J. Lipid Res. 49:2582-2589(2008) GeneRIF 5170 GAD 594365 · Mapped (1,218)
Not Associated with METABOLIC: plasma HDL cholesterol (HDL-C) levels; GAD 594365 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5170

Xia S., Chen Z., Forman L.W., Faller D.V.

Cell. Signal. 21:502-508(2009) GeneRIF 5170 · Mapped (49)
p21(Ras)-mediated survival signaling is regulated by via a PI(3)K-AKT pathway which is dependent upon both PDK1 and PKCdelta and PDK1 activates and regulates PKCdelta to determine the fate of cells containing a mutated activated p21(Ras). GeneRIF 5170

Lopez-Bergami P., Kim H., Dewing A., Goydos J., Aaronson S., Ronai Z.

J. Biol. Chem. 285:903-913(2010) GeneRIF 5170 · Mapped (8)
The identification of c-Jun as a transcriptional regulator of PDK1 expression highlights key mechanisms underlying c-Jun oncogenic activity and provides new insight into the nature of up-regulated Akt and PKC in melanoma. GeneRIF 5170

Seong H.A., Jung H., Ichijo H., Ha H.

J. Biol. Chem. 285:2397-2414(2010) GeneRIF 5170 · Mapped (27)
results provide evidence that PDK1 and ASK1 directly interact and phosphorylate each other and act as negative regulators of their respective kinases in resting cells GeneRIF 5170

Alberobello A.T., D'Esposito V., Marasco D., Doti N., Ruvo M., Bianco R., Tortora G., Esposito I., Fiory F., Miele C. et al.

J. Biol. Chem. 285:6563-6572(2010) GeneRIF 5170 · Mapped (12)
disruption of phosphoinositide-dependent kinase-1 interaction with IGF-1R reduces IGF-1 survival effects in cancer cells GeneRIF 5170

Ericson K., Gan C., Cheong I., Rago C., Samuels Y., Velculescu V.E., Kinzler K.W., Huso D.L., Vogelstein B., Papadopoulos N.

Proc. Natl. Acad. Sci. U.S.A. 107:2598-2603(2010) GeneRIF 5170 · Mapped (18)
Data show that AKT1 and AKT2 appeared to regulate growth through FOXO proteins but not through either GSK3beta or mTOR and in contrast inactivation of PDPK1 affected GSK3beta and mTOR activation. GeneRIF 5170

Sozopoulos E., Litsiou H., Voutsinas G., Mitsiades N., Anagnostakis N., Tseva T., Patsouris E., Tseleni-Balafouta S.

Endocr. Pathol. 21:90-100(2010) GeneRIF 5170 · Mapped (30)
Observational study of gene-disease association. (HuGE Navigator); We evaluated the presence of mutations in PIK3CA AKT1 AKT2 AKT3 PTEN and PDPK1 genes in 83 papillary thyroid carcinomas GeneRIF 5170