Dorr J., Bechmann I., Waiczies S., Aktas O., Walczak H., Krammer P.H., Nitsch R., Zipp F.

J. Neurosci. 22:RC209-RC209(2002) GeneRIF 8794 · Mapped (20)
TNF-related apoptosis-inducing ligand (TRAIL) is not constitutively expressed in the human brain whereas both apoptosis-mediating and apoptosis-blocking TRAIL receptors are found on neurons astrocytes and oligodendrocytes GeneRIF 8794

Ruiz de Almodovar C., Lopez-Rivas A., Redondo J.M., Rodriguez A.

FEBS Lett. 531:304-308(2002) GeneRIF 8794 · Mapped (5)
analysis of the transcription initiation sites and promoter structure of the TRAIL-R3 gene GeneRIF 8794

Ou D., Metzger D.L., Wang X., Huang J., Pozzilli P., Tingle A.J.

Diabetologia 45:1678-1688(2002) GeneRIF 8794 · Mapped (20)
Cytotoxicity and apoptosis induced by TRAIL to beta-cell lines CM were inhibited competitively by soluble TRAIL receptors R1 R2 R3 or R4. GeneRIF 8794

Hasel C., Durr S., Rau B., Strater J., Schmid R.M., Walczak H., Bachem M.G., Moller P.

Lab. Invest. 83:825-836(2003) GeneRIF 8794 · Mapped (20)
likely to be involved in chronic pancreatitis; pancreatic stellate cells may directly contribute to acinar regression by inducing apoptosis of parenchymal cells in a TRAIL-dependent manner GeneRIF 8794

Ruiz de Almodovar C., Ruiz-Ruiz C., Rodriguez A., Ortiz-Ferron G., Redondo J.M., Lopez-Rivas A.

J. Biol. Chem. 279:4093-4101(2004) GeneRIF 8794 · Mapped (37)
cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene GeneRIF 8794

Shivapurkar N., Toyooka S., Toyooka K.O., Reddy J., Miyajima K., Suzuki M., Shigematsu H., Takahashi T., Parikh G., Pass H.I. et al.

Int. J. Cancer 109:786-792(2004) GeneRIF 8794 · Mapped (6)
Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types and aberrant methylation was the cause for silencing of DcR1 and DcR2 expression. GeneRIF 8794

Cho S.M., Kim J., Ryu H.J., Kim J.J., Kim H.H., Park J.H., Kim H.T., Kim K.H., Cho H.Y., Oh B. et al.

Hum. Immunol. 65:710-718(2004) GeneRIF 8794 · Mapped (74)
Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 8794

Kimberley F.C., Screaton G.R.

Cell Res. 14:359-372(2004) GeneRIF 8794 · Mapped (18)
The DcR1 had no death domain and was anchored to the membrane via a glycophosphatidyl inositol tail. GeneRIF 8794

Sanlioglu A.D., Dirice E., Aydin C., Erin N., Koksoy S., Sanlioglu S.

BMC Cancer 5:54-54(2005) GeneRIF 8794 · Mapped (9)
TRAIL-R4 but not TRAIL-R3 is the decoy receptor which appeared to influence TRAIL sensitivity in breast cancer cells GeneRIF 8794

Riccioni R., Pasquini L., Mariani G., Saulle E., Rossini A., Diverio D., Pelosi E., Vitale A., Chierichini A., Cedrone M. et al.

Haematologica 90:612-624(2005) GeneRIF 8794 · Mapped (17)
Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R3. GeneRIF 8794

Merino D., Lalaoui N., Morizot A., Schneider P., Solary E., Micheau O.

Mol. Cell. Biol. 26:7046-7055(2006) GeneRIF 8794 · Mapped (14)
The specificity of DcR1- and DcR2-mediated TRAIL inhibition reveals an additional level of complexity for the regulation of TRAIL signaling. GeneRIF 8794

Martinez-Ferrandis J.I., Rodriguez-Lopez R., Milne R.L., Gonzalez E., Cebolla E., Chirivella I., Zamora P., Arias J.I., Palacios S., Cervantes A. et al.

Cancer Biomark 3:89-93(2007) GeneRIF 8794 · Mapped (6)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8794

Inagaki S., Morimura S., Tang Y., Akutagawa H., Kida K.

Biosci. Biotechnol. Biochem. 71:2065-2068(2007) GeneRIF 8794 · Mapped (13)
tryptophol induces apoptosis through DR5 and the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1 GeneRIF 8794

Toscano F., Fajoui Z.E., Gay F., Lalaoui N., Parmentier B., Chayvialle J.A., Scoazec J.Y., Micheau O., Abello J., Saurin J.C.

Oncogene 27:4161-4171(2008) GeneRIF 8794 · Mapped (37)
p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation. GeneRIF 8794

Hornstein M., Hoffmann M.J., Alexa A., Yamanaka M., Muller M., Jung V., Rahnenfuhrer J., Schulz W.A.

Cancer Genomics Proteomics 5:123-136(2008) GeneRIF 8794 · Mapped (8)
These data strongly support a recent proposal that a segment at 8p21.3 contains crucial prostate cancer tumor suppressors. GeneRIF 8794

Morissette M.C., Vachon-Beaudoin G., Parent J., Chakir J., Milot J.

Am. J. Respir. Crit. Care Med. 178:240-247(2008) GeneRIF 8794 · Mapped (50)
TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema GeneRIF 8794

Macartney-Coxson D.P., Hood K.A., Shi H.J., Ward T., Wiles A., O'Connor R., Hall D.A., Lea R.A., Royds J.A., Stubbs R.S. et al.

BMC Cancer 8:187-187(2008) GeneRIF 8794 · Mapped (14)
Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases GeneRIF 8794

Cheng Y., Kim J.W., Liu W., Dunn T.A., Luo J., Loza M.J., Kim S.T., Zheng S.L., Xu J., Isaacs W.B. et al.

Prostate 69:327-335(2009) GeneRIF 8794 · Mapped (5)
inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development GeneRIF 8794

Liang X.S., Caporaso N., McMaster M.L., Ng D., Landgren O., Yeager M., Chanock S., Goldin L.R.

Br. J. Haematol. 146:418-423(2009) GeneRIF 8794 · Mapped (533)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8794

Frese S., Schuller A., Frese-Schaper M., Gugger M., Schmid R.A.

Anticancer Res. 29:2905-2911(2009) GeneRIF 8794 · Mapped (13)
Low DCR1 is associated with non-small cell lung cancer. GeneRIF 8794

Hosgood H.D., Zhang L., Shen M., Berndt S.I., Vermeulen R., Li G., Yin S., Yeager M., Yuenger J., Rothman N. et al.

Occup Environ Med 66:848-853(2009) GeneRIF 8794 GAD 560995 · Mapped (1,047)
Not Associated with PHARMACOGENOMIC: benzene haematotoxicity; GAD 560995 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8794

Tarragona J., Llecha N., Santacana M., Lopez S., Gatius S., Llobet D., Dolcet X., Palomar-Asenjo V., Gonzalez-Tallada F.J., Matias-Guiu X.

Virchows Arch. 456:39-44(2010) GeneRIF 8794 · Mapped (5)
Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis. GeneRIF 8794

Davila S., Froeling F.E., Tan A., Bonnard C., Boland G.J., Snippe H., Hibberd M.L., Seielstad M.

Genes Immun. 11:232-238(2010) GeneRIF 8794 · Mapped (4,258)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8794

Lee K.M., Baris D., Zhang Y., Hosgood H.D., Menashe I., Yeager M., Zahm S.H., Wang S.S., Purdue M.P., Chanock S. et al.

Am. J. Hematol. 85:560-563(2010) GeneRIF 8794 · Mapped (320)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8794

Bisgin A., Terzioglu E., Aydin C., Yoldas B., Yazisiz V., Balci N., Bagci H., Gorczynski R.M., Akdis C.A., Sanlioglu S.

BMC Musculoskelet Disord 11:192-192(2010) GeneRIF 8794 · Mapped (5)
Decoy receptors DcR1 and DcR2 on CD8+ T cells but not on CD4-positive T cells are positively correlated with patients' DAS scores. GeneRIF 8794