Grupe A., Li Y., Rowland C., Nowotny P., Hinrichs A.L., Smemo S., Kauwe J.S., Maxwell T.J., Cherny S., Doil L. et al.

Am. J. Hum. Genet. 78:78-88(2006) GAD 593597 GeneRIF 8829 · Mapped (1,497)
Not Associated with NEUROLOGICAL: Alzheimer's disease ; GAD 593597 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8829

Walter J.W., North P.E., Waner M., Mizeracki A., Blei F., Walker J.W.T., Reinisch J.F., Marchuk D.A.

Genes Chromosomes Cancer 33:295-303(2002) GeneRIF 8829 · UniProtKB (2) · Mapped (28)
A potential mechanism involved in hemangioma formation is the alteration of the NRP1 signaling pathway in endothelial and/or pericytic cells. GeneRIF 8829

Tordjman R., Lepelletier Y., Lemarchandel V., Cambot M., Gaulard P., Hermine O., Romeo P.H.

Nat. Immunol. 3:477-482(2002) GeneRIF 8829 · Mapped (14)
A neuronal receptor neuropilin-1 is essential for the initiation of the primary immune response. GeneRIF 8829

Wulfing C., Rupp F.

Nat. Immunol. 3:418-419(2002) GeneRIF 8829 · Mapped (14)
Neuropilin-1 is another neuronal molecule in the "immunological synapse". GeneRIF 8829

Stephenson J.M., Banerjee S., Saxena N.K., Cherian R., Banerjee S.K.

Int. J. Cancer 101:409-414(2002) GeneRIF 8829 · Mapped (14)
results suggest that NRP-1 may be a multiple function protein in human breast and may be involved in the induction of local invasiveness of neoplasia and angiogenesis and have direct relevance to the progression of breast cancer GeneRIF 8829

Rossignol M., Pouyssegur J., Klagsbrun M.

J. Cell. Biochem. 88:744-757(2003) GeneRIF 8829 · UniProtKB (2) · Mapped (17)
promoter regions of human and mouse NRP1 genes were cloned and sequenced; transfection demonstrated that two Sp1 elements are major contributors to constitutive and induced activity GeneRIF 8829

Rieger J., Wick W., Weller M.

Glia 42:379-389(2003) GeneRIF 8829 · Mapped (29)
human glioma cells express class 3 semaphorins and receptors for soluble and membrane-bound semaphorins suggesting a possible role of the semaphorin/neuropilin system in the interactions of human malignant glioma with the nervous and immune systems. GeneRIF 8829

Vanveldhuizen P.J., Zulfiqar M., Banerjee S., Cherian R., Saxena N.K., Rabe A., Thrasher J.B., Banerjee S.K.

Oncol. Rep. 10:1067-1071(2003) GeneRIF 8829 · Mapped (14)
neuropilin-1 is expressed in the prostatic stromal cells not epithelial tumor cells and this expression is significantly increased in the malignant phenotype GeneRIF 8829

Bachelder R.E., Lipscomb E.A., Lin X., Wendt M.A., Chadborn N.H., Eickholt B.J., Mercurio A.M.

Cancer Res. 63:5230-5233(2003) GeneRIF 8829 · Mapped (21)
breast carcinoma cells support an autocrine pathway involving SEMA3A plexin-A1 and neuropilin-1 that impedes their ability to chemotax. GeneRIF 8829

Wang L., Zeng H., Wang P., Soker S., Mukhopadhyay D.

J. Biol. Chem. 278:48848-48860(2003) GeneRIF 8829 · Mapped (21)
independently promote cell signaling in endothelial cells and also demonstrate the importance of last three amino acids for its function GeneRIF 8829

Fukahi K., Fukasawa M., Neufeld G., Itakura J., Korc M.

Clin. Cancer Res. 10:581-590(2004) GeneRIF 8829 · Mapped (21)
Np-1 and Np-2 contribute to autocrine-paracrine interactions in pancreatic cancer GeneRIF 8829

Cheng L., Jia H., Lohr M., Bagherzadeh A., Holmes D.I., Selwood D., Zachary I.

J. Biol. Chem. 279:30654-30661(2004) GeneRIF 8829 · Mapped (39)
NP-1 has a specific role in mediating neurotrophic actions of VEGF family members GeneRIF 8829

Osada H., Tokunaga T., Nishi M., Hatanaka H., Abe Y., Tsugu A., Kijima H., Yamazaki H., Ueyama Y., Nakamura M.

Anticancer Res. 24:547-552(2004) GeneRIF 8829 · Mapped (14)
NRP1 overexpression contributes to tumor progression and has clinical significance for glioma. GeneRIF 8829

Parikh A.A., Fan F., Liu W.B., Ahmad S.A., Stoeltzing O., Reinmuth N., Bielenberg D., Bucana C.D., Klagsbrun M., Ellis L.M.

Am. J. Pathol. 164:2139-2151(2004) GeneRIF 8829 · Mapped (14)
Effect of NRP-1 overexpression on angiogenesis and growth of human colon adenocarcinoma by immunohistochemistry and in situ hybridization. GeneRIF 8829

Straume O., Akslen L.A.

Angiogenesis 6:295-301(2003) GeneRIF 8829 · Mapped (32)
Increased expression of NRP1 is associated with an aggressive angiogenic phenotype in melanoma. GeneRIF 8829

Broholm H., Laursen H.

APMIS 112:257-263(2004) GeneRIF 8829 · Mapped (14)
correlation between neuropilin-1 and vascularity in human astrocytic tumors and a possible role for neuropilin-1 as a receptor for VEGF-induced angiogenesis GeneRIF 8829

Murga M., Fernandez-Capetillo O., Tosato G.

Blood 105:1992-1999(2005) GeneRIF 8829 · Mapped (17)
dual role as an enhancer of VEGF activity and a mediator of endothelial cell adhesiveness GeneRIF 8829

Germeyer A., Hamilton A.E., Laughlin L.S., Lasley B.L., Brenner R.M., Giudice L.C., Nayak N.R.

J. Clin. Endocrinol. Metab. 90:1783-1790(2005) GeneRIF 8829 · Mapped (21)
NP-1 mRNA was highly expressed in vascular endothelium and in stromal cells but in these cells NP-1 expression did not change during the menstrual cycle. GeneRIF 8829

Becker P.M., Waltenberger J., Yachechko R., Mirzapoiazova T., Sham J.S., Lee C.G., Elias J.A., Verin A.D.

Circ. Res. 96:1257-1265(2005) GeneRIF 8829 · Mapped (35)
role for Npn-1 in regulating endothelial barrier dysfunction in response to VEGF. GeneRIF 8829

Wey J.S., Gray M.J., Fan F., Belcheva A., McCarty M.F., Stoeltzing O., Somcio R., Liu W., Evans D.B., Klagsbrun M. et al.

Br. J. Cancer 93:233-241(2005) GeneRIF 8829 · Mapped (14)
Neuropilin-1 overexpression in pancreatic cancer cell lines is associated with (a) increased constitutive MAPK signalling (b) inhibition of anoikis and (c) chemoresistance GeneRIF 8829

Kurschat P., Bielenberg D., Rossignol-Tallandier M., Stahl A., Klagsbrun M.

J. Biol. Chem. 281:2721-2729(2006) GeneRIF 8829 · Mapped (19)
Down-regulation of NRP1 by NRSF overexpression reduced Sema3A activity. It was concluded that NRSF is a transcription factor that silences NRP1 expression and thereby diminishes the Sema3A mediated inhibition of HaCaT keratinocyte migration GeneRIF 8829

von Wronski M.A., Raju N., Pillai R., Bogdan N.J., Marinelli E.R., Nanjappan P., Ramalingam K., Arunachalam T., Eaton S., Linder K.E. et al.

J. Biol. Chem. 281:5702-5710(2006) GeneRIF 8829 · Mapped (14)
Data show that tuftsin and a higher affinity antagonist TKPPR bind selectively to neuropilin-1 and block vascular endothelial growth factor (VEGF) binding to that receptor. GeneRIF 8829

Narazaki M., Tosato G.

Blood 107:3892-3901(2006) GeneRIF 8829 · Mapped (14)
Preferential receptor binding and internalization by a ligand are mechanisms by which the common receptor Npn-1 can play an essential role in prioritizing conflicting signals. GeneRIF 8829

Jia H., Bagherzadeh A., Hartzoulakis B., Jarvis A., Lohr M., Shaikh S., Aqil R., Cheng L., Tickner M., Esposito D. et al.

J. Biol. Chem. 281:13493-13502(2006) GeneRIF 8829 · Mapped (24)
This study describes the first specific antagonist of VEGF-A165 binding to NP-1 and demonstrate that NP-1 is essential for optimum KDR activation and intracellular signaling. GeneRIF 8829

Punyadeera C., Thijssen V.L., Tchaikovski S., Kamps R., Delvoux B., Dunselman G.A., de Goeij A.F., Griffioen A.W., Groothuis P.G.

Mol. Hum. Reprod. 12:367-375(2006) GeneRIF 8829 · Mapped (24)
Immunohistochemical staining showed that NRP-1 was mainly confined to stroma and blood vessels and only in late-proliferative endometrium epithelial staining was also observed. GeneRIF 8829