uniprot:O00547 in Computationally mapped citations

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Alleles of the KIR2DL4 receptor and their lack of association with pre-eclampsia. Witt C.S., Whiteway J.M., Warren H.S., Barden A., Rogers M., Martin A., Beilin L., Christiansen F.T. Eur. J. Immunol. 32:18-29(2002) GAD 140639 GAD 140640 GeneRIF 3805 · UniProtKB (3) · Mapped (26) Not Associated with REPRODUCTION: pre-eclampsia.; GAD 140639 Not Associated with REPRODUCTION: preeclampsia; GAD 140640 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3805
Maternal KIR repertoire is not associated with recurrent spontaneous abortion. Witt C.S., Goodridge J., Gerbase-Delima M.G., Daher S., Christiansen F.T. Hum. Reprod. 19:2653-2657(2004) GAD 140641 GeneRIF 3805 · Mapped (28) Not Associated with REPRODUCTION: pregnancy loss, recurrent; GAD 140641 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3805
Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. Rajagopalan S., Fu J., Long E.O. J. Immunol. 167:1877-1881(2001) GeneRIF 3805 · Mapped (28) Crosslinking of KIR2DL4 with a mAb induces interferon-gamma production but not cytotoxicity by resting NK cells in the absence of cytokines. GeneRIF 3805
SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells. Yusa S., Catina T.L., Campbell K.S. J. Immunol. 168:5047-5057(2002) GeneRIF 3805 · Mapped (28) The single tyrosine-based inhibitory motif (ITIM)in the cytoplasmic domain of KIR2DL4 efficiently inhibits natural cytotoxicity responses and recruits SHP-2 protein tyrosine phosphatase (but not SHP-1) to the 2DL4 cytoplasmic domain in NK cells. GeneRIF 3805
KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential. Faure M., Long E.O. J. Immunol. 168:6208-6214(2002) GeneRIF 3805 · Mapped (28) KIR2DL4 has the potential for both activating and inhibitory functions. GeneRIF 3805
DNA methylation maintains allele-specific KIR gene expression in human natural killer cells. Chan H.W., Kurago Z.B., Stewart C.A., Wilson M.J., Martin M.P., Mace B.E., Carrington M., Trowsdale J., Lutz C.T. J. Exp. Med. 197:245-255(2003) GeneRIF 3805 · Mapped (80) NK clones express both 2DL4 alleles and either one or both alleles of the clonally restricted KIR 3DL1 and 3DL2 genes. GeneRIF 3805
Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands. Becker S., Tonn T., Fussel T., Uhrberg M., Bogdanow M., Seifried E., Seidl C. Hum. Immunol. 64:183-193(2003) GeneRIF 3805 · Mapped (112) All genotypes seen included genes for KIR2DL4. GeneRIF 3805
Recognition of HLA-G by the NK cell receptor KIR2DL4 is not essential for human reproduction. Gomez-Lozano N., de Pablo R., Puente S., Vilches C. Eur. J. Immunol. 33:639-644(2003) GeneRIF 3805 · Mapped (101) NK cell receptor KIR2DL4:HLA-G interaction is not essential for human reproduction. GeneRIF 3805
Different and divergent regulation of the KIR2DL4 and KIR3DL1 promoters. Stewart C.A., Van Bergen J., Trowsdale J. J. Immunol. 170:6073-6081(2003) GeneRIF 3805 · Mapped (59) The promoter for KIR2DL4 is expressed by all natural killer (NK) cell clones and drives reporter gene expression only in NK cells. GeneRIF 3805
Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals. Williams F., Maxwell L.D., Halfpenny I.A., Meenagh A., Sleator C., Curran M.D., Middleton D. Hum. Immunol. 64:729-732(2003) GeneRIF 3805 · Mapped (59) isolated 3 distinct KIR2DL4 allele clones in each individual with multiple copies of KIR3DL/S1; assumption that unequal crossover event occurred between differing KIR haplotypes resulting in the duplication of the 2DL4 3DS1/3DL1 genes GeneRIF 3805
KIR2DL4 (CD158d) genotype influences expression and function in NK cells. Goodridge J.P., Witt C.S., Christiansen F.T., Warren H.S. J. Immunol. 171:1768-1774(2003) GeneRIF 3805 · UniProtKB (3) · Mapped (25) KIR2DL4 transmembrane exon genotype influences both levels of membrane expression and activation of cytotoxic function. GeneRIF 3805
KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production. Kikuchi-Maki A., Yusa S., Catina T.L., Campbell K.S. J. Immunol. 171:3415-3425(2003) GeneRIF 3805 · Mapped (28) Appropriate engagement of KIR2DL4 can selectively stimulate NK cells to elicit a strong IFN-gamma response which has the potential to contribute significant biological benefits but only in individuals capable of expressing this receptor. GeneRIF 3805
Investigation of killer cell immunoglobulinlike receptor gene diversity: I. KIR2DL4. Williams F., Meenagh A., Sleator C., Middleton D. Hum. Immunol. 65:31-38(2004) GeneRIF 3805 · Mapped (28) Specific amplification of the D0 & D2 domains permit PCR discrimination of KIR2DL4 alleles & their frequencies in various cell lines and human populations. GeneRIF 3805
The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. Gomez-Lozano N., Estefania E., Williams F., Halfpenny I., Middleton D., Solis R., Vilches C. Eur. J. Immunol. 35:16-24(2005) GeneRIF 3805 · UniProtKB (1) · Mapped (59) 4.5% of the individuals of a Caucasoid population bear a recombinant allele of KIR3DP1 officially designed KIR3DP1*004 that associates tightly with gene duplications of KIR3DP1 KIR2DL4 and KIR3DL1/KIR3DS1 GeneRIF 3805
HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells. LeMaoult J., Zafaranloo K., Le Danff C., Carosella E.D. FASEB J. 19:662-664(2005) GeneRIF 3805 · Mapped (105) report that ILT2 receptor ILT3 receptor ILT4 receptor and KIR2DL4 receptor expression is up-regulated by HLA-G histocompatibility antigen in antigen-presenting cells natural killer cells and T cells GeneRIF 3805
A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia. Arnheim L., Dillner J., Sanjeevi C.B. Tissue Antigens 65:252-259(2005) GeneRIF 3805 · Mapped (104) Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3805
Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein. Kikuchi-Maki A., Catina T.L., Campbell K.S. J. Immunol. 174:3859-3863(2005) GeneRIF 3805 · Mapped (29) evidence that FcepsilonRI-gamma (gamma) associates with 2DL4 to promote surface expression and provide signal transducing function. GeneRIF 3805
Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3. Trompeter H.I., Gomez-Lozano N., Santourlidis S., Eisermann B., Wernet P., Vilches C., Uhrberg M. J. Immunol. 174:4135-4143(2005) GeneRIF 3805 · Mapped (34) an inhibitory element was identified in the KIR2DL4 promoter and an activating element was found in the KIR3DL3 promoter; AML-2 acts as a repressor of expression of both KIR2DL4 and KIR3DL3 in mature NK cells GeneRIF 3805
Genomic characterization of KIR2DL4 in families and unrelated individuals reveals extensive diversity in exon and intron sequences including a common frameshift variation occurring in several alleles. Gedil M.A., Steiner N.K., Hurley C.K. Tissue Antigens 65:402-418(2005) GeneRIF 3805 · UniProtKB (5) · Mapped (24) KIR2DL4 alleles may explain the high frequency of this variation in the population. GeneRIF 3805
Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. Jiang K., Zhu F.M., Lv Q.F., Yan L.X. Tissue Antigens 65:556-563(2005) GeneRIF 3805 · Mapped (137) Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 3805
Activation of NK cells by an endocytosed receptor for soluble HLA-G. Rajagopalan S., Bryceson Y.T., Kuppusamy S.P., Geraghty D.E., van der Meer A., Joosten I., Long E.O. PLoS Biol. 4:e9-e9(2006) GeneRIF 3805 · Mapped (28) KIR2DL4 was constitutively internalized into Rab5-positive compartments in NK cells via dynamin-dependent process. Chemokine secretion induced by KIR2DL4 transfection into 293T cells occurred only with recombinant forms of KIR2DL4 trafficked to endosomes. GeneRIF 3805
[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population]. Zhu F.M., Jiang K., Lu Q.F., Zhang W., Zhang H.Q., Fu Q.H., Yan L.X. Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:1109-1112(2005) GeneRIF 3805 · Mapped (132) Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 3805
Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells. Goodridge J.P., Lathbury L.J., Steiner N.K., Shulse C.N., Pullikotil P., Seidah N.G., Hurley C.K., Christiansen F.T., Witt C.S. Eur. J. Immunol. 37:199-211(2007) GeneRIF 3805 · UniProtKB (2) · Mapped (27) New insights are provided into the mechanisms by which genetic polymorphism of the KIR2DL4 gene influences its expression. GeneRIF 3805
KIR haplotype content at the allele level in 77 Northern Irish families. Middleton D., Meenagh A., Gourraud P.A. Immunogenetics 59:145-158(2007) GeneRIF 3805 · Mapped (97) Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 3805
[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia]. Chen A.M., Guo X.M., Yan W.Y., Xie S.M., Zhu N., Wang X.D., Xu R., Liu Q.P. Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:35-38(2007) GeneRIF 3805 · Mapped (129) Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3805

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