Suetsugu S., Takenawa T.

J. Biol. Chem. 278:42515-42523(2003) GeneRIF 8976 · UniProtKB (1) · Mapped (14)
nuclear localization of N-WASP modulates Src kinase activity by regulating HSP90 expression GeneRIF 8976

Chen X.M., Huang B.Q., Splinter P.L., Orth J.D., Billadeau D.D., McNiven M.A., LaRusso N.F.

Infect. Immun. 72:3011-3021(2004) GeneRIF 8976 · Mapped (11)
Expression of the WA fragment of N-WASP to block associated actin polymerization also inhibited C. parvum invasion. GeneRIF 8976

Martinez-Quiles N., Ho H.Y., Kirschner M.W., Ramesh N., Geha R.S.

Mol. Cell. Biol. 24:5269-5280(2004) GeneRIF 8976 · Mapped (34)
Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex GeneRIF 8976

Ho H.-Y.H., Rohatgi R., Lebensohn A.M., Ma L., Li J., Gygi S.P., Kirschner M.W.

Cell 118:203-216(2004) GeneRIF 8976 · UniProtKB (3) · Mapped (10)
The cooperative actions of two distinct Cdc42 effectors the N-WASP-WIP complex and Toca-1 are required for Cdc42-induced actin assembly. GeneRIF 8976

Manchanda N., Lyubimova A., Ho H.Y., James M.F., Gusella J.F., Ramesh N., Snapper S.B., Ramesh V.

J. Biol. Chem. 280:12517-12522(2005) GeneRIF 8976 · Mapped (21)
NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function GeneRIF 8976

Torres E., Rosen M.K.

J. Biol. Chem. 281:3513-3520(2006) GeneRIF 8976 · Mapped (6)
WASP and N-WASP are activated and phosphorylated by protein-tyrosine kinase and GTPase signals GeneRIF 8976

Haller C., Rauch S., Michel N., Hannemann S., Lehmann M.J., Keppler O.T., Fackler O.T.

J. Biol. Chem. 281:19618-19630(2006) GeneRIF 8976 · Mapped (5)
Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity GeneRIF 8976

Wu X., Yoo Y., Okuhama N.N., Tucker P.W., Liu G., Guan J.L.

Nat. Cell Biol. 8:756-763(2006) GeneRIF 8976 · Mapped (5)
We demonstrate that the interaction of N-WASP with the PSF-NonO complex can couple N-WASP with RNA polymerase II to regulate transcription. GeneRIF 8976

Kakimoto T., Katoh H., Negishi M.

J. Biol. Chem. 281:29042-29053(2006) GeneRIF 8976 · UniProtKB (1) · Mapped (11)
a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP GeneRIF 8976

Le Clainche C., Schlaepfer D., Ferrari A., Klingauf M., Grohmanova K., Veligodskiy A., Didry D., Le D., Egile C., Carlier M.F. et al.

J. Biol. Chem. 282:426-435(2007) GeneRIF 8976 · Mapped (23)
signal-induced relief of the autoinhibited fold of IQGAP1 allows activation of N-WASP to stimulate Arp2/3-dependent actin assembly GeneRIF 8976

Suetsugu S., Banzai Y., Kato M., Fukami K., Kataoka Y., Takai Y., Yoshida N., Takenawa T.

Genes Cells 12:721-733(2007) GeneRIF 8976 · UniProtKB (1) · Mapped (20)
CR16 and N-WASP are suggested to play important roles in spermatogenesis GeneRIF 8976

Martin T.A., Pereira G., Watkins G., Mansel R.E., Jiang W.G.

Clin. Exp. Metastasis 25:97-108(2008) GeneRIF 8976 · Mapped (5)
N-WASP a member of the N-WASP family may act as a tumour progression suppressor in human breast cancer and may therefore have significant clinical value in this condition. GeneRIF 8976

Leung Y., Ally S., Goldberg M.B.

Cell Host Microbe 3:39-47(2008) GeneRIF 8976 · Mapped (11)
These data constitute evidence that Toca-1 is required for N-WASP-mediated actin polymerization by Shigella flexneri in vivo. GeneRIF 8976

Wegner A.M., Nebhan C.A., Hu L., Majumdar D., Meier K.M., Weaver A.M., Webb D.J.

J. Biol. Chem. 283:15912-15920(2008) GeneRIF 8976 · Mapped (7)
of N-WASP and subsequently the Arp2/3 complex appears to be an important molecular signal for regulating spines and synapses GeneRIF 8976

Bompard G., Rabeharivelo G., Morin N.

BMC Cell Biol. 9:42-42(2008) GeneRIF 8976 · Mapped (5)
Wiskostatin induced defective cytokinesis does not occur through the inhibition of the N-WASP pathway. GeneRIF 8976

Xiao F., Wang X.F., Li J.M., Xi Z.Q., Lu Y., Wang L., Zeng Y., Guan L.F., Yuan J.

Brain Res. 1233:168-175(2008) GeneRIF 8976 · Mapped (10)
Compared with controls neuronal Wiskott-Aldrich syndrome protein expression in brains of intractable epilepsy patients was significantly higher. GeneRIF 8976

Bu W., Chou A.M., Lim K.B., Sudhaharan T., Ahmed S.

J. Biol. Chem. 284:11622-11636(2009) GeneRIF 8976 · Mapped (11)
the Toca-1-N-WASP complex can link filopodial formation to endocytosis GeneRIF 8976

Weisswange I., Newsome T.P., Schleich S., Way M.

Nature 458:87-91(2009) GeneRIF 8976 · Mapped (15)
the exchange rate of N-WASP controls the rate of ARP2/3-complex-dependent actin-based motility by regulating the extent of actin polymerization by antagonizing filament capping GeneRIF 8976

Wang W.S., Zhong H.J., Xiao D.W., Huang X., Liao L.D., Xie Z.F., Xu X.E., Shen Z.Y., Xu L.Y., Li E.M.

Dis. Esophagus 23:512-521(2010) GeneRIF 8976 · Mapped (7)
CFL1 and N-WASP may play an important role in the tumorigenesis of ESCC and to be the candidate novel biomarkers for the diagnosis and prognosis of esophageal squamous cell carcinoma. GeneRIF 8976

Miller M.M., Lapetina S., MacGrath S.M., Sfakianos M.K., Pollard T.D., Koleske A.J.

Biochemistry 49:2227-2234(2010) GeneRIF 8976 · Mapped (23)
Arg promotes actin-based protrusions in response to extracellular stimuli through phosphorylation of and physical interactions with N-WASp. GeneRIF 8976

Misra A., Rajmohan R., Lim R.P., Bhattacharyya S., Thanabalu T.

Exp. Cell Res. 316:2810-2824(2010) GeneRIF 8976 · Mapped (21)
Cdc42 regulates the activity of IRSp53 by regulating the IRSp53-WIRE interaction as well as localization of the complex to plasma membrane to generate filopodia. GeneRIF 8976

Bu W., Lim K.B., Yu Y.H., Chou A.M., Sudhaharan T., Ahmed S.

PLoS ONE 5:e12153-e12153(2010) GeneRIF 8976 · Mapped (18)
Cdc42 may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP complex. GeneRIF 8976

Sanchez A.M., Flamini M.I., Baldacci C., Goglia L., Genazzani A.R., Simoncini T.

Mol. Endocrinol. 24:2114-2125(2010) GeneRIF 8976 · Mapped (14)
Recruitment of FAK and N-WASP is necessary for cell migration and invasion induced by 17beta-estradiol in breast cancer cells. GeneRIF 8976

Park S.J., Takenawa T.

Mol. Cells 31:515-521(2011) GeneRIF 8976 · Mapped (5)
N-WASP plays a role in efficient assembly of kinetochores and attachment of microtubules to chromosomes which is essential for accurate chromosome congression and segregation GeneRIF 8976

Galovic M., Xu D., Areces L.B., van der Kammen R., Innocenti M.

J. Cell. Sci. 124:2001-2012(2011) GeneRIF 8976 · Mapped (5)
Perturbation of N-WASP-CK2 complex function showed that N-WASP controls the presence of F-actin at clathrin-coated structures. N-WASP-CK2 complex integrates in a single circuit different activities contributing to CME. GeneRIF 8976