Kitaura-Inenaga K., Hara M., Higuchi K., Yamamoto K., Yamaki A., Ono K., Nakano A., Kinoshita M., Sasayama S., Matsumori A.

Circ. J. 67:881-884(2003) GeneRIF 17229 · Mapped (6)
mast cell mMCP-4 -5 and -6 (chymase and tryptase) participate in the acute inflammation and remodeling process of viral myocarditis. GeneRIF 17229

Nico B., Marzullo A., Corsi P., Vacca A., Roncali L., Ribatti D.

Neuroscience 123:585-588(2004) GeneRIF 17229 · Mapped (11)
Tryptase contained in the neurons and in the endothelial cells of the mdx mouse brain may be involved in the regulation of angiogenesis taking place in mdx mouse. GeneRIF 17229

Hallgren J., Backstrom S., Estrada S., Thuveson M., Pejler G.

J. Immunol. 173:1868-1875(2004) GeneRIF 17229 · Mapped (3)
Molecular modeling of MMCP6 identified 4 conserved & exposed His residues H35 H106 H108 & H238. These surface-exposed histidines mediate the interaction of mast cell tryptase with heparin & are critical in the formation of active tryptase tetramers. GeneRIF 17229

Funaba M., Ikeda T., Murakami M., Ogawa K., Abe M.

Cell. Signal. 17:121-128(2005) GeneRIF 17229 · Mapped (3)
Gene expression is activated by the TGF-beta/activin pathway and the differential regulation by the isoforms suggest a rigorous regulation of mast cell function. GeneRIF 17229

Thakurdas S.M., Melicoff E., Sansores-Garcia L., Moreira D.C., Petrova Y., Stevens R.L., Adachi R.

J. Biol. Chem. 282:20809-20815(2007) GeneRIF 17229 · UniProtKB (1) · Mapped (2)
mMCP-6 has a critical immunoprotective role in bacterial infections GeneRIF 17229

Shin K., Watts G.F., Oettgen H.C., Friend D.S., Pemberton A.D., Gurish M.F., Lee D.M.

J. Immunol. 180:4885-4891(2008) GeneRIF 17229 · Mapped (3)
mast cell secretion of the tryptase mMCP-6 a function directed by the activity of the adaptive immune system contributes to eosinophil recruitment to the site of larval infection GeneRIF 17229

McNeil H.P., Shin K., Campbell I.K., Wicks I.P., Adachi R., Lee D.M., Stevens R.L.

Arthritis Rheum. 58:2338-2346(2008) GeneRIF 17229 · Mapped (7)
Because mMCP-6 and mMCP-7 can compensate for each other in this mouse disease model the elimination of both tryptases is necessary to reveal the prominent roles of these serine proteases in joint inflammation and destruction. GeneRIF 17229

de Vries V.C., Elgueta R., Lee D.M., Noelle R.J.

Transplant. Proc. 42:2759-2762(2010) GeneRIF 17229 · Mapped (3)
MCP6 actively depletes the local environment of IL-6 to maintain tolerance in mice. GeneRIF 17229

Hamilton M.J., Sinnamon M.J., Lyng G.D., Glickman J.N., Wang X., Xing W., Krilis S.A., Blumberg R.S., Adachi R., Lee D.M. et al.

Proc. Natl. Acad. Sci. U.S.A. 108:290-295(2011) GeneRIF 17229 · Mapped (8)
MCP-6 (but not MCP-7) is an essential mast cell-restricted mediator in chemically induced colitis and acts upstream of many of the factors implicated in inflammatory bowel disease. GeneRIF 17229

Zhang J., Sun J., Lindholt J.S., Sukhova G.K., Sinnamon M., Stevens R.L., Adachi R., Libby P., Thompson R.W., Shi G.P.

Circ. Res. 108:1316-1327(2011) GeneRIF 17229 · Mapped (14)
direct participation of mast cell tryptase in the pathogenesis of experimental abdominal aortic aneurysms GeneRIF 17229

Mortaz E., Givi M.E., Da Silva C.A., Folkerts G., Redegeld F.A.

Biochim. Biophys. Acta 1822:1154-1160(2012) GeneRIF 17229 · Mapped (3)
this study indicates that mast cells may be a source of TGF-beta production after cigarette smoke exposure and that in turn TGF-beta may change the tryptase expression in mast cells. GeneRIF 17229