Mangold E., Ludwig K.U., Birnbaum S., Baluardo C., Ferrian M., Herms S., Reutter H., de Assis N.A., Chawa T.A., Mattheisen M. et al.

Nat. Genet. 42:24-26(2010) GAD 597766 · Mapped (14)
Associated with DEVELOPMENTAL: nonsyndromic cleft lip with or without cleft palate; GAD 597766

Chen B., Athanasiou M., Gu Q., Blair D.G.

Biochem. Biophys. Res. Commun. 295:1135-1141(2002) GeneRIF 26585 · Mapped (9)
Drm/Gremlin transcriptionally activates p21(Cip1) via a novel mechanism and inhibits neoplastic transformation. GeneRIF 26585

Dolan V., Murphy M., Alarcon P., Brady H.R., Hensey C.

Expert Opin. Ther. Targets 7:523-526(2003) GeneRIF 26585 · Mapped (3)
Review. Gremlin a developmental regulator of bone morphogenetic proteins (BMPs) has recently been implicated in processes such as glomerulosclerosis tubulointerstitial fibrosis and cellular hypertrophy. GeneRIF 26585

Chen B., Blair D.G., Plisov S., Vasiliev G., Perantoni A.O., Chen Q., Athanasiou M., Wu J.Y., Oppenheim J.J., Yang D.

J. Immunol. 173:5914-5917(2004) GeneRIF 26585 · UniProtKB (3) · Mapped (5)
Data demonstrate for the first time that Drm physically and functionally interacts with Slit proteins to act as a negative regulator for monocyte chemotaxis. GeneRIF 26585

Gazzerro E., Pereira R.C., Jorgetti V., Olson S., Economides A.N., Canalis E.

Endocrinology 146:655-665(2005) GeneRIF 26585 · Mapped (6)
transgenic mice overexpressing gremlin in the bone microenvironment have decreased osteoblast number and function leading to osteopenia and spontaneous fractures. GeneRIF 26585

Dolan V., Murphy M., Sadlier D., Lappin D., Doran P., Godson C., Martin F., O'Meara Y., Schmid H., Henger A. et al.

Am. J. Kidney Dis. 45:1034-1039(2005) GeneRIF 26585 · Mapped (12)
TFG-beta is an inducer of gremlin expression in diabetic nephropathy. GeneRIF 26585

Suzuki M., Shigematsu H., Shames D.S., Sunaga N., Takahashi T., Shivapurkar N., Iizasa T., Frenkel E.P., Minna J.D., Fujisawa T. et al.

Br. J. Cancer 93:1029-1037(2005) GeneRIF 26585 · Mapped (11)
Down-Regulation of gremlin aberrant methylation is associated with cancer GeneRIF 26585

Namkoong H., Shin S.M., Kim H.K., Ha S.A., Cho G.W., Hur S.Y., Kim T.E., Kim J.W.

BMC Cancer 6:74-74(2006) GeneRIF 26585 · Mapped (8)
gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein GeneRIF 26585

Boers W., Aarrass S., Linthorst C., Pinzani M., Elferink R.O., Bosma P.

J. Biol. Chem. 281:16289-16295(2006) GeneRIF 26585 · Mapped (6)
gremlin and insulin-like growth factor-binding proteins have roles in liver fibrogenesis GeneRIF 26585

Sneddon J.B., Zhen H.H., Montgomery K., van de Rijn M., Tward A.D., West R., Gladstone H., Chang H.Y., Morganroth G.S., Oro A.E. et al.

Proc. Natl. Acad. Sci. U.S.A. 103:14842-14847(2006) GeneRIF 26585 · Mapped (8)
GREMLIN 1 was expressed in the stroma of human basal cell carcinoma (BCC) tumors but not in normal skin in vivo. Bone morphogenetic protein (BMP) 2 and 4 are expressed by BCC cells. GeneRIF 26585

Frank N.Y., Kho A.T., Schatton T., Murphy G.F., Molloy M.J., Zhan Q., Ramoni M.F., Frank M.H., Kohane I.S., Gussoni E.

J. Cell Biol. 175:99-110(2006) GeneRIF 26585 · Mapped (5)
BMP4 and Gremlin are regulators of myogenic progenitor proliferation. GeneRIF 26585

Mezzano S., Droguett A., Burgos M.E., Aros C., Ardiles L., Flores C., Carpio D., Carvajal G., Ruiz-Ortega M., Egido J.

Nephrol. Dial. Transplant. 22:1882-1890(2007) GeneRIF 26585 · Mapped (3)
May play role infibrous process in crescentic nephritis both in glomerular crescentic and tubular epithelial cells. May be important in mediating some of the pathological effects of TGF-beta. GeneRIF 26585

Myllarniemi M., Lindholm P., Ryynanen M.J., Kliment C.R., Salmenkivi K., Keski-Oja J., Kinnula V.L., Oury T.D., Koli K.

Am. J. Respir. Crit. Care Med. 177:321-329(2008) GeneRIF 26585 · Mapped (15)
in human bronchial epithelial cells asbestos-induced gremlin expression could be prevented by inhibitors of the TGF-beta receptor and also by inhibitors of the mitogen-activated protein kinase kinase/extracellular signal-regulated protein kinase pathways GeneRIF 26585

Walsh D.W., Roxburgh S.A., McGettigan P., Berthier C.C., Higgins D.G., Kretzler M., Cohen C.D., Mezzano S., Brazil D.P., Martin F.

Biochim. Biophys. Acta 1782:10-21(2008) GeneRIF 26585 · Mapped (7)
Notch pathway gene expression is elevated in diabetic nephropathy co-incident with Gremlin and may contribute to the pathogenesis of this dise GeneRIF 26585

Sha G., Zhang Y., Zhang C., Wan Y., Zhao Z., Li C., Lang J.

Fertil. Steril. 91:350-358(2009) GeneRIF 26585 · Mapped (3)
Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis. GeneRIF 26585

Costello C.M., Howell K., Cahill E., McBryan J., Konigshoff M., Eickelberg O., Gaine S., Martin F., McLoughlin P.

Am. J. Physiol. Lung Cell Mol. Physiol. 295:L272-84(2008) GeneRIF 26585 · Mapped (6)
the mechanisms of pulmonary hypertension and vascular loss in chronic lung disease and identifies gremlin 1 as a potentially important mediator of vascular changes in hypoxic pulmonary hypertension. GeneRIF 26585

Kami D., Shiojima I., Makino H., Matsumoto K., Takahashi Y., Ishii R., Naito A.T., Toyoda M., Saito H., Watanabe M. et al.

PLoS ONE 3:e2407-e2407(2008) GeneRIF 26585 · Mapped (6)
Grem1 enhances the determined path to cardiomyogenesis in a stage-specific manner and inhibition of the BMP signaling pathway is involved in initial determination of Grem1-promoted cardiomyogenesis GeneRIF 26585

Zode G.S., Clark A.F., Wordinger R.J.

Glia 57:755-766(2009) GeneRIF 26585 · Mapped (8)
Gremlin was expressed in optic nerve head (ONH) tissue & cells; gremlin levels were increased in lamina cribrosa region of glaucomatous ONH tissues; increased expression of gremlin in glaucoma ONH may exacerbate TGF-beta2 effects on ONH ECM metabolism GeneRIF 26585

Yerges L.M., Klei L., Cauley J.A., Roeder K., Kammerer C.M., Moffett S.P., Ensrud K.E., Nestlerode C.S., Marshall L.M., Hoffman A.R. et al.

J. Bone Miner. Res. 24:2039-2049(2009) GeneRIF 26585 · Mapped (1,348)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 26585

Gibson L., Johnson N., Fraser A., dos Santos Silva I., Houlston R., Peto J., Fletcher O.

Cancer Epidemiol. Biomarkers Prev. 18:1934-1936(2009) GeneRIF 26585 GAD 567962 · Mapped (6)
Not Associated with CANCER: breast cancer ; GAD 567962 Observational study of gene-disease association. (HuGE Navigator); None of the single nucleotide polymorphisms studied in SMAD7 GREM1 or CRAC1 were associated with breast cancer risk in our study GeneRIF 26585

Thameem F., Puppala S., He X., Arar N.H., Stern M.P., Blangero J., Duggirala R., Abboud H.E.

Metab. Clin. Exp. 58:1496-1502(2009) GeneRIF 26585 · Mapped (3)
the variants examined at GREM1 are not significant contributors to variation in albumin to creatinine ratio in Mexican Americans GeneRIF 26585

Fajardo M., Liu C.J., Egol K.

Clin. Orthop. Relat. Res. 467:3071-3078(2009) GeneRIF 26585 · Mapped (13)
Data suggest inhibition of BMP-7 by Drm (Gremlin) follistatin and Noggin and upregulation of BMP-4 may play an integral role in the development of nonunions. GeneRIF 26585

van Vlodrop I.J., Baldewijns M.M., Smits K.M., Schouten L.J., van Neste L., van Criekinge W., van Poppel H., Lerut E., Schuebel K.E., Ahuja N. et al.

Am. J. Pathol. 176:575-584(2010) GeneRIF 26585 · Mapped (3)
A role for GREM1 in clear cell renal cell carcinoma carcinogenesis and tumor angiogenesis. GeneRIF 26585

McKnight A.J., Patterson C.C., Pettigrew K.A., Savage D.A., Kilner J., Murphy M., Sadlier D., Maxwell A.P.

J. Am. Soc. Nephrol. 21:773-781(2010) GeneRIF 26585 · Mapped (3)
Observational study of gene-disease association. (HuGE Navigator); Variant rs1129456 associates with diabetic nephropathy. GeneRIF 26585

Dimitrov B.I., Voet T., De Smet L., Vermeesch J.R., Devriendt K., Fryns J.P., Debeer P.

J. Med. Genet. 47:569-574(2010) GeneRIF 26585 · Mapped (4)
Chromosomal imbalances in the GREM1 FMN1 region in individuals with limb defects are reported here. GeneRIF 26585