Hayashi K., Shimizu M., Ino H., Okeie K., Yamaguchi M., Yasuda T., Fujino N., Fujii H., Fujita S., Mabuchi H.

Jpn Heart J 41:399-404(2000) GAD 129239 · Mapped (14)
Associated with CARDIOVASCULAR: cardiovascular; GAD 129239

Pietila E., Fodstad H., Niskasaari E., Laitinen P P.J., Swan H., Savolainen M., Kesaniemi Y.A., Kontula K., Huikuri H.V.

J. Am. Coll. Cardiol. 40:511-514(2002) GAD 129238 GAD 129240 GeneRIF 3757 · Mapped (14)
Associated with CARDIOVASCULAR: QT interval; Cohort 226/187 random middle-aged population (226 men/187 women) GAD 129240 Associated with CARDIOVASCULAR: unknown; GAD 129238 Observational study of gene-disease association. (HuGE Navigator); The common K897T polymorphism of the HERG channel is associated with the maximal duration and transmural dispersion of ventricular repolarization in middle-aged females. GeneRIF 3757

Priori S.G., Napolitano C., Schwartz P.J., Grillo M., Bloise R., Ronchetti E., Moncalvo C., Tulipani C., Veia A., Bottelli G. et al.

JAMA 292:1341-1344(2004) GAD 129249 GeneRIF 3757 · Mapped (31)
Associated with CARDIOVASCULAR: EKG, abnormal; Cohort 335 consecutive LQTS-genotyped patients Italy GAD 129249 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 3757

Akyol M., Jalilzadeh S., Sinner M.F., Perz S., Beckmann B.M., Gieger C., Illig T., Wichmann H.E., Meitinger T., Kaab S. et al.

Eur. Heart J. 28:305-309(2007) GAD 150439 GeneRIF 3757 · Mapped (21)
Associated with CARDIOVASCULAR: EKG, abnormal; GAD 150439 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3757

Schwartz P.J., Priori S.G., Spazzolini C., Moss A.J., Vincent G.M., Napolitano C., Denjoy I., Guicheney P., Breithardt G., Keating M.T. et al.

Circulation 103:89-95(2001) GeneRIF 3757 · Mapped (31)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 3757

Itoh T., Kikuchi K., Odagawa Y., Takata S., Yano K., Okada S., Haneda N., Ogawa S., Nakano O., Kawahara Y. et al.

J. Hum. Genet. 46:38-40(2001) GeneRIF 3757 · Mapped (40)
Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 3757

Ficker E., Obejero-Paz C.A., Zhao S., Brown A.M.

J. Biol. Chem. 277:4989-4998(2002) GeneRIF 3757 · Mapped (14)
the trafficking-deficient pore mutation HERG G601S was rescued by a series of HERG channel blockers that increased cell surface expression. Rescue by these pharmacological chaperones varied directly with their blocking potency. GeneRIF 3757

Allan W.C., Timothy K., Vincent G.M., Palomaki G.E., Neveux L.M., Haddow J.E.

J Med Screen 8:173-177(2001) GeneRIF 3757 · Mapped (31)
Observational study of gene-disease association genetic testing and healthcare-related. (HuGE Navigator) GeneRIF 3757

Moss A.J., Zareba W., Kaufman E.S., Gartman E., Peterson D.R., Benhorin J., Towbin J.A., Keating M.T., Priori S.G., Schwartz P.J. et al.

Circulation 105:794-799(2002) GeneRIF 3757 · Mapped (14)
Patients with mutations in the pore region of the HERG gene are at markedly increased risk for arrhythmia-related cardiac events compared with patients with nonpore mutations GeneRIF 3757

Pardo-Lopez L., Zhang M., Liu J., Jiang M., Possani L.D., Tseng G.N.

J. Biol. Chem. 277:16403-16411(2002) GeneRIF 3757 · Mapped (14)
Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule GeneRIF 3757

Yang P., Kanki H., Drolet B., Yang T., Wei J., Viswanathan P.C., Hohnloser S.H., Shimizu W., Schwartz P.J., Stanton M. et al.

Circulation 105:1943-1948(2002) GeneRIF 3757 · UniProtKB (2) · Mapped (29)
Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 3757

Kupershmidt S., Yang T., Chanthaphaychith S., Wang Z., Towbin J.A., Roden D.M.

J. Biol. Chem. 277:27442-27448(2002) GeneRIF 3757 · Mapped (14)
a key function of the C-terminal 104 amino acids is to mask the RGR ER retention signal which becomes exposed when mutations truncate the HERG C terminus. GeneRIF 3757

Korolkova Y.V., Bocharov E.V., Angelo K., Maslennikov I.V., Grinenko O.V., Lipkin A.V., Nosyreva E.D., Pluzhnikov K.A., Olesen S.-P., Arseniev A.S. et al.

J. Biol. Chem. 277:43104-43109(2002) GeneRIF 3757 · UniProtKB (1) · Mapped (14)
identification of the residues that are important for the binding specificity to the scorpion toxin BeKm-1 GeneRIF 3757

Chen J., Seebohm G., Sanguinetti M.C.

Proc. Natl. Acad. Sci. U.S.A. 99:12461-12466(2002) GeneRIF 3757 · Mapped (16)
positioning of S6 aromatic residues relative to the central cavity of the channel not inactivation per se determines drug block of HERG or eag channels GeneRIF 3757

Roti E.C., Myers C.D., Ayers R.A., Boatman D.E., Delfosse S.A., Chan E.K., Ackerman M.J., January C.T., Robertson G.A.

J. Biol. Chem. 277:47779-47785(2002) GeneRIF 3757 · Mapped (22)
the cytoplasmic C terminus of HERG participates in the tethering or possibly targeting of HERG-containing vesicles within the Golgi via its interaction with GM130 GeneRIF 3757

Paulussen A., Raes A., Matthijs G., Snyders D.J., Cohen N., Aerssens J.

J. Biol. Chem. 277:48610-48616(2002) GeneRIF 3757 · UniProtKB (1) · Mapped (13)
determination of relation of a PAS domain mutation in HERG to a trafficking deficiency at body temperature apart from effects on channel deactivation GeneRIF 3757

Jongbloed R., Marcelis C., Velter C., Doevendans P., Geraedts J., Smeets H.

Hum. Mutat. 20:382-391(2002) GeneRIF 3757 · Mapped (20)
Observational study of genetic testing. (HuGE Navigator) GeneRIF 3757

Shoeb F., Malykhina A.P., Akbarali H.I.

J. Biol. Chem. 278:2503-2514(2003) GeneRIF 3757 · Mapped (14)
Description of a HERG isoform found in human and rabbit colon that has a functional role in smooth muscle GeneRIF 3757

Crociani O., Guasti L., Balzi M., Becchetti A., Wanke E., Olivotto M., Wymore R.S., Arcangeli A.

J. Biol. Chem. 278:2947-2955(2003) GeneRIF 3757 · UniProtKB (1) · Mapped (13)
cell cycle dependent expression of isoforms in tumor cells GeneRIF 3757

Liu W., Yang J., Hu D., Kang C., Li C., Zhang S., Li P., Chen Z., Qin X., Ying K. et al.

Hum. Mutat. 20:475-476(2002) GeneRIF 3757 · Mapped (20)
Three KCNH2 mutations L413P E444D and L559H were identified in long QT syndrome in China. GeneRIF 3757

Zhang Y., Wang H., Wang J., Han H., Nattel S., Wang Z.

FEBS Lett. 534:125-132(2003) GeneRIF 3757 · Mapped (21)
We conclude that normal HERG function in HEK293 cells requires basal activity of PKB. Our data represent the first evidence that PKB phosphorylation regulates K(+) channels GeneRIF 3757

Gomez-Varela D., Barros F., Viloria C.G., Giraldez T., Manso D.G., Dupuy S.G., Miranda P., de la Pena P.

FEBS Lett. 535:125-130(2003) GeneRIF 3757 · Mapped (14)
Different proximal amino-terminal domain sequences contribute to set HERG gating characteristics and its regulation by TRH GeneRIF 3757

D'Amico M., Biagiotti T., Fontana L., Restano-Cassulini R., Lasagna N., Arcangeli A., Wanke E., Olivotto M.

Biochem. Biophys. Res. Commun. 302:101-108(2003) GeneRIF 3757 · Mapped (14)
sustains a cardiac-type action potential in neuroblastoma S cells GeneRIF 3757

Zhang S., Kehl S.J., Fedida D.

J. Physiol. (Lond.) 548:691-702(2003) GeneRIF 3757 · Mapped (14)
The strong effects of Cs+ on inactivation but not on activation highlight the importance of ion and channel interactions during the onset of inactivation in the HERG channel. GeneRIF 3757

Bauer C.K., Wulfsen I., Schaefer R., Glassmeier G., Wimmers S., Flitsch J., Luedecke D.K., Schwarz J.R.

Pflugers Arch. 445:589-600(2003) GeneRIF 3757 · UniProtKB (2) · Mapped (16)
Transcripts for HERG1 were present in all adenomas and although transcripts for HERG2 and HERG3 were also detected their expression level was more variable. GeneRIF 3757