Numazaki M., Tominaga T., Toyooka H., Tominaga M.

J. Biol. Chem. 277:13375-13378(2002) GeneRIF 7442 · UniProtKB (1) · Mapped (11)
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues GeneRIF 7442

Ugawa S., Ueda T., Ishida Y., Nishigaki M., Shibata Y., Shimada S.

J. Clin. Invest. 110:1185-1190(2002) GeneRIF 7442 · Mapped (11)
ASICs are leading acid sensors in human nociceptors and VR1 participates in the nociception mainly under extremely acidic conditions. GeneRIF 7442

Chan C.L., Facer P., Davis J.B., Smith G.D., Egerton J., Bountra C., Williams N.S., Anand P.

Lancet 361:385-391(2003) GeneRIF 7442 · Mapped (7)
In rectal hypersensitivity nerve fibres immunoreactive to TRPV1 were increased in muscle submucosal and mucosal layers. GeneRIF 7442

Numazaki M., Tominaga T., Takeuchi K., Murayama N., Toyooka H., Tominaga M.

Proc. Natl. Acad. Sci. U.S.A. 100:8002-8006(2003) GeneRIF 7442 · UniProtKB (1) · Mapped (8)
calmodulin binds to a 35-aa segment in the C terminus of TRPV1 and disruption of the calmodulin-binding segment prevents TRPV1 desensitization GeneRIF 7442

Mohapatra D.P., Wang S.Y., Wang G.K., Nau C.

Mol. Cell. Neurosci. 23:314-324(2003) GeneRIF 7442 · Mapped (7)
Proposal that residue Y671 is critical for the high relative Ca(2+) permeability of TRPV1 and participates in the structural rearrangements of the channel protein leading to Ca(2+)-dependent desensitization. GeneRIF 7442

Mohapatra D.P., Nau C.

J. Biol. Chem. 278:50080-50090(2003) GeneRIF 7442 · Mapped (8)
Ser-116 and possibly Thr-370 are the most important residues involved in the cyclic AMP-dependent protein kinase pathway reduction of desensitization of capsaicin-activated currents; Ser-116 and possibly Thr-370 of vanilloid receptor TRPV1 are the most important residues involved in the mechanism of PKA-dependent reduction of desensitization of capsaicin-activated currents GeneRIF 7442

Renton T., Yiangou Y., Baecker P.A., Ford A.P., Anand P.

J Orofac Pain 17:245-250(2003) GeneRIF 7442 · Mapped (8)
in fibers of human tooth pulp ... may play a role in perception of dental pain GeneRIF 7442

Jung J., Shin J.S., Lee S.-Y., Hwang S.W., Koo J., Cho H., Oh U.

J. Biol. Chem. 279:7048-7054(2004) GeneRIF 7442 · UniProtKB (1) · Mapped (7)
vanilloid receptor 1 has a role in regulating vanilloid binding with Ca2+/calmodulin-dependent kinase II GeneRIF 7442

Staender S., Moormann C., Schumacher M., Buddenkotte J., Artuc M., Shpacovitch V., Brzoska T., Lippert U., Henz B.M., Luger T.A. et al.

Exp. Dermatol. 13:129-139(2004) GeneRIF 7442 · UniProtKB (1) · Mapped (6)
VR1 is widely distributed in the skin suggesting a major role for this receptor e.g. in nociception and neurogenic inflammation. GeneRIF 7442

Geppetti P., Trevisani M.

Br. J. Pharmacol. 141:1313-1320(2004) GeneRIF 7442 · Mapped (7)
Review notes that high expression of TRPV1 has been detected in inflammatory diseases of the colon and ileum whereas neuropeptides released upon sensory nerve stimulation triggered by TRPV1 activation may play a role in intestinal motility disorders. GeneRIF 7442

Garcia-Sanz N., Fernandez-Carvajal A., Morenilla-Palao C., Planells-Cases R., Fajardo-Sanchez E., Fernandez-Ballester G., Ferrer-Montiel A.

J. Neurosci. 24:5307-5314(2004) GeneRIF 7442 · UniProtKB (1) · Mapped (7)
Our observations suggest that the homologous TRP domain in the TRP protein family may function as a general evolutionary conserved AD involved in subunit multimerization GeneRIF 7442

Voets T., Droogmans G., Wissenbach U., Janssens A., Flockerzi V., Nilius B.

Nature 430:748-754(2004) GeneRIF 7442 · UniProtKB (1) · Mapped (11)
temperature sensing is tightly linked to voltage-dependent gating in the cold-sensitive channel TRPM8 and the heat-sensitive channel TRPV1 GeneRIF 7442

Jones N.G., Slater R., Cadiou H., McNaughton P., McMahon S.B.

J. Neurosci. 24:10974-10979(2004) GeneRIF 7442 · Mapped (12)
There is a minor role for transient receptor potential vanilloid receptor-1 as a mediator of cutaneous acid-induced pain. GeneRIF 7442

Lu G., Henderson D., Liu L., Reinhart P.H., Simon S.A.

Mol. Pharmacol. 67:1119-1127(2005) GeneRIF 7442 · Mapped (7)
TRPV1b receptors are expressed in trigeminal ganglion neurons and contribute to thermal nociception. GeneRIF 7442

McNamara F.N., Randall A., Gunthorpe M.J.

Br. J. Pharmacol. 144:781-790(2005) GeneRIF 7442 · Mapped (7)
Piperine was agonistic to TRPV1 as measured by patch-clamp techniques. TRPV1 was antagonized by the competitive antagonist capsazepine and the non-competitive TRPV1 blocker ruthenium red. GeneRIF 7442

Mohapatra D.P., Nau C.

J. Biol. Chem. 280:13424-13432(2005) GeneRIF 7442 · Mapped (8)
Ca2+-dependent desensitization of TRPV1 might be in part regulated through channel dephosphorylation by calcineurin GeneRIF 7442

Apostolidis A., Brady C.M., Yiangou Y., Davis J., Fowler C.J., Anand P.

Urology 65:400-405(2005) GeneRIF 7442 · Mapped (7)
Increased urothelial TRPV1 in patients with neurogenic detrusor overactivity may play a role in the pathophysiology in concert with increased TRPV1 nerve fibers. GeneRIF 7442

Ugawa S., Ueda T., Yamamura H., Nagao M., Shimada S.

Chem. Senses 30 Suppl 1:i195-i195(2005) GeneRIF 7442 · Mapped (11)
expression of vanilloid receptor subtype-1 and acid-sensing ion channel genes in the human trigeminal ganglion neurons GeneRIF 7442

Bodo E., Biro T., Telek A., Czifra G., Griger Z., Toth B.I., Mescalchin A., Ito T., Bettermann A., Kovacs L. et al.

Am. J. Pathol. 166:985-998(2005) GeneRIF 7442 · Mapped (7)
TRPV1 as a significant novel player in human hair growth control. GeneRIF 7442

Lazzeri M., Vannucchi M.G., Spinelli M., Bizzoco E., Beneforti P., Turini D., Faussone-Pellegrini M.S.

Eur. Urol. 48:691-698(2005) GeneRIF 7442 · Mapped (7)
A progressive loss of TRPV1 expression in the urothelium as TCC stage increased and cell differentiation was lower. GeneRIF 7442

Movahed P., Jonsson B.A., Birnir B., Wingstrand J.A., Jorgensen T.D., Ermund A., Sterner O., Zygmunt P.M., Hogestatt E.D.

J. Biol. Chem. 280:38496-38504(2005) GeneRIF 7442 · Mapped (8)
several endogenous non-cannabinoid N-acylethanolamines activate TRPV(1) GeneRIF 7442

Tousova K., Vyklicky L., Susankova K., Benedikt J., Vlachova V.

Mol. Cell. Neurosci. 30:207-217(2005) GeneRIF 7442 · Mapped (7)
Gadolinium activates and potentiates the TRPV1 by neutralizing two specific proton-sensitive sites on the extracellular side of the pore-forming loop. GeneRIF 7442

Sato J., Segami N., Yoshitake Y., Kaneyama K., Abe A., Yoshimura H., Fujimura K.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:674-681(2005) GeneRIF 7442 · Mapped (7)
may play a role in maintenance of the physiologic condition of the TMJ GeneRIF 7442

Zhang X., Huang J., McNaughton P.A.

EMBO J. 24:4211-4223(2005) GeneRIF 7442 · Mapped (11)
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels GeneRIF 7442

Appendino G., Cascio M.G., Bacchiega S., Moriello A.S., Minassi A., Thomas A., Ross R., Pertwee R., De Petrocellis L., Di Marzo V.

FEBS Lett. 580:568-574(2006) GeneRIF 7442 · Mapped (9)
Results describe the modification of 12-phenylacetyl-ricinoleoyl-vanillamide and its activity at TRPV1 and CB2 receptors. GeneRIF 7442