Total number of reviewed animal toxin entries: 5,813 .

Total number of reviewed venom protein entries: 6,258 .

Common name	Scientific name	Toxins	Proteins found in venom	Species producing toxins	Species secreting venom
Snakes	Serpentes	1,934	2,277	205	208
Spiders	Araneae	1,388	1,463	99	100
Snails	Gastropoda	1,173	1,181	108	106
Scorpions	Scorpiones	768	959	72	77
Sea anemones	Actiniaria	235	0	44	0
Insects	Hexapoda	75	258	38	79
Lizards	Anguimorpha	34	37	7	7
Fishes	Teleostei	29	15	10	5
Scolopendra	Scolopendridae	49	52	3	4
Mammals	Mammalia	7	6	2	1
Hydra	Hydroida	4	0	2	0
Toad	Amphibia	76	3	16	2
Mites	Acari	3	0	2	0
Starfishes	Asteroidea	3	3	1	1
Worms	Cerebratulus	3	0	1	0
Medusae	Rhopilema	1	0	1	0
Jellyfishes	Cubozoa	5	0	4	0
other metazoans	-	26	4	12	2
All animals	Metazoa	5,813	6,258	627	592

Venom protein targets in UniProtKB/Swiss-Prot distributed by taxonomical group. The idea for the table originates from the nomenclature proposition made by King et al. 2008 (PMID:18619481). The table proposed in this paper has been completed and links between venom proteins and targets have been added. Since this table may also help in nomenclature discussions, the descriptors (Greek letter that specifies the biological function) proposed by these authors are also indicated (see 2nd column). Note that multiple descriptors used for sodium channels are due to different modes of action on this channel. The targets are firstly ordered by types: ion channels, receptors (7TM and 1TM) and transporters, and secondly by abundance.

target: ion channel (voltage-gated and transmitter-gated)	descriptor	snake	scorpion	spider	cone snail	insect	sea anemone	all
voltage-gated sodium (Nav) channel	beta, delta, iota, mu	1	360	150	94	3	89	701
potassium channel inhibitor (Includes the following 4 channels: KIR, K2P, Kv and KCa as targets)	-	51	294	102	40	6	69	589
- voltage-gated potassium (Kv) channel	kappa	45	188	90	22	0	65	423
- calcium-activated potassium (KCa) channel	lambda	11	48	7	0	3	0	69
- inward-rectifier potassium (KIR) channel	eta	0	0	0	0	1	0	1
- two-pore domain potassium (K2P) channel	theta	0	0	0	0	0	0	0
nicotinic acetylcholine receptor	alpha, psi	277	0	0	152	0	0	429
calcium channel inhibitor (Includes CaV and Ryr)	-	55	25	119	83	7	0	305
- voltage-gated calcium (Cav) channel	omega	11	3	112	77	6	0	213
- ryanodine receptor (RyR)	phi	8	19	0	0	0	0	28
- P2RX receptor	omicron	0	0	2	0	0	0	2
chloride channel inhibitor (Includes CLCN, CFTR and GABA(A) as targets)	-	2	18	0	0	0	0	20
- voltage-gated chloride channels (CLCN)	epsilon	0	18	0	0	0	0	18
- CFTR channel	LAMBDA - in upper case	0	1	0	0	0	0	1
- GABA(A) receptor	SIGMA - in upper case	0	0	0	0	0	0	0
glutamate receptor	GAMMA - in upper case	0	0	2	19	0	0	21
HCNa nonspecific cation channel	gamma	0	0	0	7	0	0	7
cyclic nucleotide-gated channel	zeta	10	0	0	0	0	0	10
transient receptor potential (TRP) channel	tau	0	0	4	0	0	3	16
acid-sensing ion (ASICs) channel	pi	0	0	1	0	0	1	2
5-HT receptor	sigma	0	0	0	1	0	0	1
target: receptor 7TM	descriptor	snake	scorpion	spider	cone snail	insect	sea anemone	all
muscarinic acetylcholine receptor	-	27	0	0	0	0	0	27
adrenoceptor	rho	13	12	0	1	0	0	27
bradykinin receptor	-	6	2	5	0	10	0	92
dopamine receptor	-	1	0	0	0	0	0	1
vasopressin/oxytocin receptor	upsilon	0	0	0	4	0	0	4
endothelin receptor	xi	6	0	0	0	0	0	6
vasoactive intestinal polypeptide receptor	-	0	0	0	0	0	0	4
glucagon-like peptide receptor	-	0	0	0	0	0	0	3
somatostatin receptor	-	0	0	0	2	0	0	2
cholecystokinin receptor	-	0	0	0	0	0	0	1
neurotensin receptor	nu	0	0	0	3	0	0	3
target: receptor 1TM	descriptor	snake	scorpion	spider	cone snail	insect	sea anemone	all
vascular endothelial growth factor receptor	-	16	0	0	0	0	0	16
epidermal growth factor receptor	OMEGA - in upper case	0	0	0	0	0	4	4
target: transporter	descriptor	snake	scorpion	spider	cone snail	insect	sea anemone	all
noradrenaline transporter	chi	0	0	0	8	0	0	8
glutamate transporter	-	0	0	1	0	0	0	1

Snake venom proteins - 2,277 reviewed entries.

Evidence for the existence of protein	Percentage of entries
at protein level	67.9%
at transcript level	24.2%
inferred from homology	7.9%
predicted	N/A
uncertain	N/A

Annotation categories	Entries with	Number of annotations	Coverage
PubMed citations	2,277	1,867 unique	100%
General annotation	2,277	11,062	100%
Function	2,188	2,332	96.1%
Catalytic activity	512	514	22.5%
Subcellular location	0	0	N/A
Toxic dose	278	305	12.2%
Sequence annotation	2,272	25,230	99.8%
Amino acid modifications	2,068	11,570	90.8%
Cross-references	2,277	31,078	100%
EMBL	1,364	1,700	59.9%
InterPro	1,981	6,988	87%
PDB	246	557	10.8%

100% of reviewed snake venom proteins entries are annotated with at least one keyword .

99.9% of reviewed snake venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Snail venom proteins - 1,181 reviewed entries.

Evidence for the existence of protein	Percentage of entries
at protein level	35.8%
at transcript level	53.9%
inferred from homology	10.1%
predicted	N/A
uncertain	0.2%

Annotation categories	Entries with	Number of annotations	Coverage
PubMed citations	1,181	463 unique	100%
General annotation	1,181	5,159	100%
Function	577	584	48.9%
Catalytic activity	4	4	0.3%
Subcellular location	0	0	N/A
Toxic dose	7	7	0.6%
Sequence annotation	1,166	7,711	98.7%
Amino acid modifications	1,067	3,944	90.3%
Cross-references	1,180	6,476	100%
EMBL	734	976	62.2%
InterPro	771	1,018	65.3%
PDB	78	165	6.6%
Conoserver	863	946	73.1%

100% of reviewed snail venom proteins entries are annotated with at least one keyword .

99.8% of reviewed snail venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Scorpion venom proteins - 959 reviewed entries.

Evidence for the existence of protein	Percentage of entries
at protein level	59.5%
at transcript level	27.3%
inferred from homology	13.1%
predicted	N/A
uncertain	N/A

Annotation categories	Entries with	Number of annotations	Coverage
PubMed citations	959	666 unique	100%
General annotation	959	3,738	100%
Function	848	884	88.4%
Catalytic activity	15	15	1.6%
Subcellular location	0	0	N/A
Toxic dose	88	93	9.2%
Sequence annotation	954	5,393	99.5%
Amino acid modifications	786	2,842	82%
Cross-references	955	7,745	100%
EMBL	509	656	53.1%
InterPro	713	1,607	74.3%
PDB	93	163	9.7%

100% of reviewed scorpion venom proteins entries are annotated with at least one keyword .

99.4% of reviewed scorpion venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Spider venom proteins - 1,463 reviewed entries.

Evidence for the existence of protein	Percentage of entries
at protein level	44%
at transcript level	50.6%
inferred from homology	5.4%
predicted	N/A
uncertain	N/A

Annotation categories	Entries with	Number of annotations	Coverage
PubMed citations	1,463	380 unique	100%
General annotation	1,463	6,418	100%
Function	1,160	1,165	79.3%
Catalytic activity	217	217	14.8%
Subcellular location	0	0	N/A
Toxic dose	107	123	7.3%
Sequence annotation	1,453	9,614	99.3%
Amino acid modifications	1,260	4,130	86.1%
Cross-references	1,460	9,569	100%
EMBL	1,038	1,358	71%
InterPro	1,088	1,435	74.4%
PDB	68	99	4.6%
ArachnoServer	1,138	1,147	77.8%

100% of reviewed spider venom proteins entries are annotated with at least one keyword .

99.5% of reviewed spider venom proteins entries are annotated with at least one GO (Gene Ontology ) term.