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The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.


  • Forthcoming changes
    Planned changes for UniProt

  • UniProt release 2015_06
    POLQ, a new target for cancer therapy?

  • UniProt release 2015_05
    A never-ending race between evolution and genomic integrity | Removal of IPI species proteome data sets from FTP site | UniProtKB XSD ch...

  • UniProt release 2015_04
    Of CAT tails and protein translation by-products | Reducing redundancy in proteomes | Retirement of UniProt Metagenomic and Environmenta...

  • UniProt release 2015_03
    Regulation of translation initiation through folding | New proteomics mapping files | New FTP repository for reference proteomes | UniPa...

News archive

Getting started

  • Text search
    Our basic text search allows you to search all the resources available

    Find regions of similarity between your sequences

  • Sequence alignments
    Align two or more protein sequences using the Clustal Omega program

  • Retrieve/ID mapping
    This tool merges the "Retrieve" and "ID Mapping" tools

UniProt data

Protein spotlight

a question of perspective

Paradigms are meant to be broken. In the 1980s, biology students were taught "the one gene = one protein" dogma which has since stepped down from its pedestal, as we now know that one gene, by way of any number of post-translational modifications on the protein sequence, can actually give rise to more than one protein. Or what would be more correct: to more than one function…