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Welcome to the new UniProt website! We hope you enjoy the new design. If you’re not quite ready yet, you can still go back to the old site.

The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.


  • Ubiquitin caught at its own game | New human variant types available on the FTP site
    UniProt release 2014_08

  • Lark or owl? PER3 is the answer | Cross-references to CCDS and GeneReviews | UniParc cross-references with protein and gene names | FTP ...
    UniProt release 2014_07

  • Everything you always wanted to know about sperm-egg interaction | Extension of the UniProtKB accession number format | SAAS data remova...
    UniProt release 2014_06

  • A flounder... on the rocks! | Update of ECO mapping for evidences | Cross-references for isoform sequences: RefSeq | Addition of cross-r...
    UniProt release 2014_05

News archive

Getting started

  • Text search
    Our basic text search allows you to search all the resources available

    Find regions of similarity between your sequences

  • Sequence alignments
    Align two or more protein sequences using the Clustal Omega program

  • Upload lists
    This tool merges the "Retrieve" and "ID Mapping" tools

UniProt data

Protein spotlight

two's company

Pairing up is sometimes paramount to life. On the molecular scale, dimerization in our bodies is at the heart of many fundamental biological processes, such as the transduction of signals from the outside of a cell to the inside for instance. Split two molecules apart and, just like taking the propeller away from a ship, things are sure to change drastically. Signal transduction, on which life depends, is hugely due to protein-protein interaction…